Gene specific PCR primers were constructed for five mouse and three bovine CXC chemokine genes. The mouse genes were assigned using SSCP analyses of the Jackson BSS backcross panel to two groups on chromosome 5. One group containing Gro1 and Mip2 cosegregated with reference markers Alb1 and Btc, and was positioned 2.2 cM proximal to a group comprising Ifi10, Mig, and Scyb5. The bovine genes IL8, GRO1, and GRO3, mapped using bovine × hamster somatic cell hybrids, were all found to be located on chromosome 6. The locations of these genes in these two animal species are consistent with the positions in humans (4q13→q21), and previous syntenic relationships among these three mammals.

Baggiolini M, DeWald B, Moser B: Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv Immunol 55:97–179 (1994).
Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:1811–1815 (1995).
DeBry RW, Seldin MF: Human/mouse homology relationships. Genomics 33:337–351 (1996).
Hogan MB, Sherry C, Ritchlin C, Fabre M, Winchester R, Cerami A, Bucala R: Differential expression of the small inducible cytokines Groα and Groβ by synovial fibroblasts in chronic arthritis: possible role in growth regulation. Cytokine 6:61–69 (1994).
Modi WS, Chen Z-Q: Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids. Genomics 47:136–139 (1998).
Nomura M, Matsuda Y, Itoh H, Hori T, Suzuki G: Genetic mapping of the mouse stromal cell-derived factor gene (Sdf1) to mouse and rat chromosomes. Cytogenet Cell Genet 73:286–289 (1996).
Orita M, Suzuki Y, Sekiya T, Hayashi K: Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5:874–879 (1989).
Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko MSH, Thurston SJ, Birkenmeier EH: Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mammal Genome 5:253–274 (1994).
Sakaguchi AY, Lalley PA, Choudhury GG, Martinez L, Han ES, Killary AM, Naylor SL, Wang LM: Mouse melanoma growth stimulatory activity gene (Mgsa) is polymorphic and syntenic with the W, patch, rumpwhite, and recessive spotting loci on chromosome 5. Genomics 5:629–632 (1989).
Taub DD, Oppenheim JJ: Chemokines, inflammation and the immune system. Therap Immunol 1:229–246 (1994).
Womack JE, Moll YD: Gene map of the cow: conservation of linkage with mouse and man. J Hered 77:2–7 (1986).
Zhang N, Threadgill DW, Womack JE: Synteny mapping in the bovine: genes from human chromosome 4. Genomics14:131–136 (1992).
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