Since the first chromosome painting study between human and strepsirrhine primates was performed in 1996, nearly 30 species in Strepsirrhini, Dermoptera and Scandentia have been analyzed by cross-species chromosome painting. Here, the contribution of chromosome painting data to our understanding of primate genome organization, chromosome evolution and the karyotype phylogenetic relationships within strepsirrhine primates, Dermoptera and Scandentia is reviewed. Twenty-six to 43 homologous chromosome segments have been revealed in different species with human chromosome-specific paint probes. Various landmark rearrangements characteristic for each different lineage have been identified, as cytogenetic signatures that potentially unite certain lineages within strepsirrhine primates, Dermoptera and Scandentia.

Keywords:
Chromosome painting, Flying lemurs, Lemurs, Lorises, Syntenic associations, Tree shrews
1.
Adkins RM, Honeycutt RL: Molecular phylogeny of the superorder Archonta. Proc Natl Acad Sci USA 88:10317–10321 (1991).
2.
Apiou F, Rumpler Y, Warter S, Vezuli A, Dutrillaux B: Demonstration of homoeologies between human and lemur chromosomes by chromosome painting. Cytogenet Cell Genet 72:50–52 (1996).
3.
Arnason U, Adegoke JA, Bodin K, Born EW, Esa YB, et al: Mammalian mitogenomic relationships and the root of the eutherian tree. Proc Natl Acad Sci USA 99:8151–8156 (2002).
4.
Bailey WJ, Slightom JL, Goodman M: Rejection of the ‘flying primate’ hypothesis by phylogenetic evidence from the epsilon-globin gene. Science 256:86–89 (1992).
5.
Beard KC: Phylogenetic systematics of the Primatomorpha, with special reference to Dermopter, in Szalay FS, Novacek MJ, Mckenna MC (eds): Mammal Phylogeny: Placentals (Springer, New York 1993).
6.
Bininda-Emonds OR, Cardillo M, Jones KE, MacPhee RD, Beck RM, et al: The delayed rise of present-day mammals. Nature 446:507–512 (2007).
7.
Cardone MF, Ventura M, Tempesta S, Rocchi M, Archidiacono N: Analysis of chromosome conservation in Lemur catta studied by chromosome paints and BAC/PAC probes. Chromosoma 111:348–356 (2002).
8.
Chowdhary BP, Raudsepp T, Frönicke L, Scherthan H: Emerging patterns of comparative genome organization in some mammalian species as revealed by Zoo-FISH. Genome Res 8:577–589 (1998).
9.
Corbert GB, Hill JE: The mammals of the Indomalayan region: a systematic review. (Oxford University Press, Oxford 1992).
10.
Dumas F, Houck ML, Bigoni F, Perelman P, Romanenko SA, et al: Chromosome painting of the Pygmy tree shrew shows that no derived cytogenetic traits link Primates and Scandentia. Cytogenet Genome 136:175–179 (2012).
11.
Dutrillaux B: Chromosomal evolution in primates: tentative phylogeny from Microcebus murinus (Prosimian) to man. Hum Genet 48:251–314 (1979).
12.
Dutrillaux B, Couturier J: The ancestral karyotype of platyrrhine monkeys. Cytogenet Cell Genet 30:232–242 (1981).
13.
Dutrillaux B, Couturier J, Warter S, Rumpler Y: Chromosomal evolution in ‘lemurs.’ VI. Chromosomal banding studies of Galago senegalensis, Galago alleni, Galago demidovii and Euoticus elegantulus. Folia Primatol (Basel) 37:280–296 (1982).
14.
Ferguson-Smith MA, Trifonov V: Mammalian karyotype evolution. Nature Rev Genet 8:950–962 (2007).
15.
Frönicke L: Origins of primate chromosomes – as delineated by Zoo-FISH and alignments of human and mouse draft genome sequences. Cytogenet Genome Res 108:122–138 (2005).
16.
Frönicke L, Wienberg J, Stone G, Adams L, Stanyon R: Towards the delineation of the ancestral eutherian genome organization: comparative genome maps of human and the African elephant (Loxodonta africana) generated by chromosome painting. Proc R Soc Lond B Biol Sci 270:1331–1340 (2003).
17.
Groves C: Order primates, in Wilson DE, Reeder DM (eds): Mammal Species of the World, ed 3 (Johns Hopkins University Press, Baltimore 2005).
18.
Heaney L, Balete D, Dolar L, Alcala A, Dans A, et al: A synopsis of the mammalian fauna of the Philippine Islands. Fieldiana: Zool New Ser 88:1–61 (1998).
19.
Helgen KM: Order Scandentia, in Wilson DE, Reeder DM (eds): Mammal Species of the World: A Taxonomic and Geographic Reference, ed 3 (Smithsonian Institution Press, Washington 2005).
20.
Helgen KM: Order Scandentia, in O’Brien SJ, Menninger JC, Nash WG (eds): Atlas of Mammalian Chromosomes, pp 95–97 (John Wiley and Sons Inc, New York 2006).
21.
Horvath JE, Willard HF: Primate comparative genomics: lemur biology and evolution. Trends Genet 23:173–182 (2007).
22.
Hsu TC, Benirschke K: An Atlas of Mammalian Chromosomes Volume 7, pp 339–340 (Springer Verlag, Berlin 1973).
23.
Hudelot C, Gowri-Shankar V, Jow H, Rattray M, Higgs PG: RNA-based phylogenetic methods: application to mammalian RNA sequences. Mol Phylogenet Evol 28:241–252 (2003).
24.
Janecka JE, Miller W, Pringle TH, Wiens F, Zitzmann A, et al: Molecular and genomic data identify the closest living relative of primates. Science 318:792–794 (2007).
25.
Kay RF, Thewissen JG, Yoder AD: Cranial anatomy of Ignacius graybullianus and the affinities of the Plesiadapiformes. Am J Phys Anthropol 89:477–498(1992).
26.
Kehrer-Sawatzki H, Cooper DN: Molecular mechanisms of chromosomal rearrangement during primate evolution. Chromosome Res 16:41–56 (2008).
27.
Korstanje R, O’Brien PC, Yang F, Rens W, Bosma AA, et al: Complete homology maps of the rabbit (Oryctolagus cuniculus) and human by reciprocal chromosome painting. Cytogenet Cell Genet 86:317–322 (1999).
28.
Liu FGR, Miyamoto MM, Freire NP, Ong PQ, Tennant MR, et al: Molecular and morphological supertrees for eutherian (placental) mammals. Science 291:1786–1789 (2001).
29.
Martin RD: Primate Origins and Evolution: A Phylogenetic Reconstruction (Chapman Hall/Princeton University Press, London/Princeton 1990).
30.
Müller S, O’Brien PC, Ferguson-Smith MA, Wienberg J: Reciprocal chromosome painting between human and prosimians (Eulemur macaco macaco and E. fulvus mayottensis). Cytogenet Cell Genet 78:260–271 (1997).
31.
Müller S, Stanyon R, O’Brien PC, Ferguson-Smith MA, Plesker R, Wienberg J: Defining the ancestral karyotype of all primates by multidirectional chromosome painting between tree shrews, lemurs and humans. Chromosoma 108:393–400 (1999).
32.
Murphy WJ, Eizirik E, Johnson WE, Zhang YP, Ryder OA, et al: Molecular phylogenetics and the origins of placental mammals. Nature 409:614–618 (2001a).
33.
Murphy WJ, Eizirik E, O’Brien SJ, Madsen O, Scally M, et al: Resolution of the early placental mammal radiation using Bayesian phylogenetics. Science 294:2348–2351 (2001b).
34.
Murphy WJ, Stanyon R, O’Brien SJ: Evolution of mammalian genome organization inferred from comparative gene mapping. Genome Biol 2:REVIEWS0005 (2001c).
35.
Murphy WJ, Pevzner PA, O’Brien SJ: Mammalian phylogenomics comes of age. Trends Genet 20:631–639 (2004).
36.
Nie W, Fu B, O’Brien PC, Wang W, Su W, et al: Chromosome painting between human and lorisiform prosimians: evidence for the HSA 7/16 synteny in the primate ancestral karyotype. Am J Phys Anthropol 129:250–259 (2006).
37.
Nie W, Fu B, O’Brien PC, Wang J, Su W, et al: Flying lemurs – the ‘flying tree shrews’? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade. BMC Biol 6:18 (2008).
38.
Novacek MJ: Mammalian phylogeny: shaking the tree. Nature 356:121–125 (1992).
39.
Nowak RM: Walker’s Mammals of the World, vol 2, ed 6 (The Johns Hopkins University Press, Baltimore 1999).
40.
O’Brien SJ, Stanyon R: Phylogenomics. Ancestral primate viewed. Nature 402:365–366 (1999).
41.
O’Brien SJ, Menotti-Raymond M, Murphy WJ, Nash WG, Wienberg J, et al: The promise of comparative genomics in mammals. Science 286:458–462 (1999).
42.
Picone B, Masters J, Silvestro D, Sineo L, DelPero M: A phylogenetic analysis of human syntenies revealed by chromosome painting in euarchontoglires orders. J Mammal Evol 18:131–146 (2011).
43.
Richard F, Lombard M, Dutrillaux B: Reconstruction of the ancestral karyotype of eutherian mammals. Chromosome Res 11:605–618 (2003).
44.
Rickart EA: Chromosomes of Philippine mammals (Insectivora, Dermoptera, Primates, Rodentia, Carnivora). Proc Biol Soc Wash 116:699–709 (2003).
45.
Rumpler Y, Dutrillaux B: Chromosomal evolution in Malagasy lemurs. I. Chromosome banding studies in the genuses Lemur and Microcebus. Cytogenet and Cell Genet 17:268–281 (1976).
46.
Rumpler Y, Dutrillaux B: Chromosomal evolution in Malagasy lemurs. III. Chromosome banding studies in the genus Hapalemur and the species Lemur catta. Cytogenet and Cell Genet 21:201–211 (1978).
47.
Rumpler Y, Dutrillaux B: Chromosomal evolution in Malagasy lemurs. IV. Chromosome banding studies in the genuses Phaner, Varecia, Lemur, Microcebus, and Cheirogalus. Cytogenet and Cell Genet 24:224–232 (1979).
48.
Rumpler Y, Dutrillaux B: Chromosomal evolution and speciation in Primates. University of the Basque Country, vol 23 (Springer Verlag, Berlin 1990).
49.
Rumpler Y, Couturier J, Warter S, Dutrillaux B: Chromosomal evolution in Malagasy lemurs. VII. Phylogenic relationships between Propithecus, Avahi (Indriidae), Microcebus (Cheirogaleidae), and Lemur (Lemuridae). Cytogenet Cell Genet 36:542–546 (1983a).
50.
Rumpler Y, Couturier J, Warter S, Dutrillaux B: The karyotype of Galago crassicaudatus is ancestral for lorisiforms. Folia Primatol 40:227–231 (1983b).
51.
Rumpler Y, Ishak B, Warter S, Dutrillaux B: Chromosomal evolution in Malagasy lemurs. VIII. Chromosome banding studies of Lepilemur ruficaudatus, L. leucopus, and L. septentrionalis. Cytogenet Cell Genet 39:194–199 (1985).
52.
Rumpler Y, Warter S, Meier B, Preuschoft H, Dutrillaux B: Chromosomal phylogeny of three Lorisidae: Loris tardigradus, Nycticebus coucang, and Perodicticus potto. Folia Primatologica 48:216–220 (1987).
53.
Rumpler Y, Water S, Ishak B, Dutrillaux B: Chromosomal evolution in Prosimians. Hum Evol 4:157–170 (1989).
54.
Rumpler Y, Warter S, Hauwy M, Fausser JL, Roos C, Zinner D: Comparing chromosomal and mitochondrial phylogenies of sportive lemurs (Genus Lepilemur, Primates). Chromosome Res 16:1143–1158 (2008).
55.
Scherthan H, Cremer T, Arnason U, Weier HU, Lima-de-Faria A, Frönicke L: Comparative chromosome painting discloses homologous segments in distantly related mammals. Nat Genet 6:342–347 (1994).
56.
Schmitz J, Ohme M, Zischler H: The complete mitochondrial genome of Tupaia belangeri and the phylogenetic affiliation of Scandentia to other eutherian orders. Mol Biol Evol 17:1334–1343 (2000).
57.
Silcox MT, Bloch JI, Sargis EJ, Boyer DM: Euarchonta (Dermoptera, Scandentia, Primates), in Rose KD, Archibald JD (eds): The Rise of Placental Mammals (The Johns Hopkins University Press, Baltimore 2005).
58.
Springer MS, Murphy WJ, Eirizik E, O’Brien SJ: Placental mammal diversification and the Cretaceous-Tertiary boundary. Proc Natl Acad Sci USA 100:1056–1061 (2003).
59.
Springer MS, Stanhope MJ, Madsen O, de Jong WW: Molecules consolidate the placental mammal tree. Trends Ecol Evol 19:430–438 (2004).
60.
Stafford BJ, Szalay FS: Craniodental functional morphology and taxonomy of dermopterans. J Mammal 81:360–385 (2000).
61.
Stanyon R, Koehler U, Consigliere S: Chromosome painting reveals that galagos have highly derived karyotypes. Am J Phys Anthropol 117:319–326 (2002).
62.
Stanyon R, Dumas F, Stone G, Bigoni F: Multidirectional chromosome painting reveals a remarkable syntenic homology between the greater galagos and the slow loris. Am J Primatol 68:349–359 (2006).
63.
Stanyon R, Rocchi M, Capozzi O, Roberto R, Misceo D, et al: Primate chromosome evolution: ancestral karyotypes, marker order and neocentromeres. Chromosome Res 16:17–39 (2008).
64.
Toder R, Vonholst D, Schempp W: Comparative cytogenetic studies in tree shrews (Tupaia). Cytogenet Cell Genet 60:55–59 (1992).
65.
Vezuli A, Hauwy M, Warter S, Rumpler Y: Chromosome painting: a method for testing chromosomal changes in lemur evolution. Cytogenet Cell Genet 78:147–152 (1997).
66.
Waddell PJ, Okada N, Hasegawa M: Towards resolving the interordinal relationships of placental mammals. Syst Biol 48:1–5 (1999).
67.
Waddell PJ, Kishino H, Ota R: A phylogenetic foundation for comparative mammalian genomics. Genome Inform 12:141–154 (2001).
68.
Warter S, Hauwy M, Dutrillaux B, Rumpler Y: Application of molecular cytogenetics for chromosomal evolution of the Lemuriformes (Prosimians). Cytogenet Genome Res 108:197–203 (2005).
69.
Wienberg J: Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution. Cytogenet Genome Res 108:139–160 (2005).
70.
Wienberg J, Stanyon R: Chromosome painting in mammals as an approach to comparative genomics. Curr Opin Genet Dev 5:792–797 (1995).
71.
Wienberg J, Stanyon R: Comparative painting of mammalian chromosomes. Curr Opin Genet Dev 7:784–791 (1997).
72.
Wienberg J, Stanyon R: Comparative chromosome painting of primate genomes. ILAR J 39:77–91(1998).
73.
Yang F, Alkalaeva EZ, Perelman PL, Pardini AT, Harrison WR, et al: Reciprocal chromosome painting among human, aardvark, and elephant (superorder Afrotheria) reveals the likely eutherian ancestral karyotype. Proc Natl Acad Sci USA 100:1062–1066 (2003).
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