Cytogenetics of wild and captive bred non-domestic animals provides us with valuable information that can be implemented in wildlife management and species conservation strategies. In this review, we summarized the data published to date describing a range of chromosome abnormalities observed in non-domestic animals and their effect on phenotype. Two important factors that can potentially have drastic effects on captive breeding programs are discussed: presence of classic chromosome abnormalities, spontaneously-occurring and inherited, and intraspecific variations in chromosome number. Short-term consequences, primarily reduced reproductive efficiency, and long-term consequences, such as changes in population dynamics, are examined.

Alaoui N, Jordana J, Ponsa M: A centric fission and heterochromatin polymorphism in Equus asinus Spanish breeds. J Anim Breed Genet 121:135–141 (2004).
Andrle M, Fiedler W, Rett A, Ambros P, Schweizer D: A case of trisomy 22 in Pongo pygmaeus. Cytogenet Cell Genet 24:1–6 (1979).
Baker FJ, Bickham JW: Speciation by monobrachial centric fusions. Proc Natl Acad Sci USA 83:8245–8248 (1986).
Benirschke K, Kumamoto AT: Mammalian cytogenetics and conservation of species. J Hered 82:187–191 (1991).
Benirschke K, Kumamoto AT, Olsen JH, Williams MM, Oosterhuis J: On the chromosomes of Gazella soemmeringi. Cretzschmar, 1826. Z Säugetierkd 49:368–373 (1984).
Bosma AA: Chromosomal polymorphism and G-banding patterns in the wild boar (Sus scrofa L.) from the Netherlands. Genetica 46:391–399 (1976).
Buckland RA, Evans HJ: Cytogenetic aspects of phylogeny in the Bovidae. I. G-banding. Cytogenet Cell Genet 21:42–63 (1978).
Cribiu EP, Asmonde JF, Durand V, Greth A, Anagariyah S: Robertsonian chromosome polymorphism in the Arabian oryx (Oryx leucoryx). Cytogenet Cell Genet 54:161–163 (1990).
De Waal FB, Uno H, Luttrell LM, Meisner LF, Jeannotte LA: Behavioral retardation in a macaque with autosomal trisomy and aging mother. Am J Ment Retard 100:378–390 (1996).
Dudley CJ, Hubbard GB, Moore CM, Dunn BG, Raveendran M, et al: A male baboon (Papio hamadryas) with a mosaic 43,XXY/42,XY karyotype. Am J Med Genet 140:94–97 (2006).
Eldridge MDB, Pearson DJ: Chromosomal rearrangements in rock wallabies, Petrogale (Marsupialia: Macropodidae). IX. Further G-banding studies of the Petrogale lateralis complex: P.lateralis pearsoni, the West Kimberly race, and a population heterozygous for a centric fusion. Genome 40:84–90 (1997).
Fontana F, Rubini M: Chromosomal evolution in Cervidae. Biosystems 24:157–174 (1990).
Frönicke L, Wienberg J: Comparative chromosome painting defines the high rate of karyotype changes between pigs and bovids. Mamm Genome 12:442–449 (2001).
Gallagher DS Jr, Womack JE: Chromosome conservation in the Bovidae. J Hered 83:287–298 (1992).
Glas R, De Leo AA, Delbridge ML, Reid K, Ferguson-Smith MA, et al: Chromosome painting in marsupials: genome conservation in the kangaroo family. Chromosome Res 7:167–176 (1999).
Gustavsson I: Time for revival of clinical cytogenetics? Hung J Anim Product 48:10–14 (1999).
Gustavsson I, Sundt CO: Three polymorphic chromosome systems of centric fusion type in a population of Manchurian sika deer (Cervus nippon hortulorum Swinhoe). Chromosoma 28:245–254 (1969).
Hinrichs K, Horin SE, Buoen LC, Zhang TQ, Ruth GR: X-chromosome monosomy in an infertile female llama. J Am Vet Med Assoc 210:1503–1504 (1997).
Hinrichs K, Buoen LC, Ruth GR: XX/XY chimerism and freemartinism in a female llama co-twin to a male. J Am Vet Med Assoc 215:1140–1141 (1999).
Houck ML, Ryder OA, Vahala J, Kock RA, Oosterhuis JE: Diploid chromosome number and chromosomal variation in the white rhinoceros (Ceratotherium simum). J Hered 85:30–34 (1994).
Houck ML, Kumamoto AT, Cabrera RM, Benirschke K: Chromosomal rearrangements in a Somali wild ass pedigree, Equus africanus somaliensis (Perissodactyla, Equidae). Cytogenet Cell Genet 80:117–122 (1998).
Howell KH, Hubbard GB, Moore CM, Dunn BG, von Kap-Herr C, et al: Trisomy of chromosome 18 in the baboon (Papio hamadryas anubis). Cytogenet Genome Res 112:76–81 (2006).
Kingswood SC, Kumamoto AT: Madoqua kirkii. Mamm Species 569:1–10 (1997).
Kingswood SC, Kumamoto AT, Charter SJ, Jones ML: Cryptic chromosomal variation in suni Neotragus moschatus (Artiodactyla, Bovidae). Anim Conserv 1:95–100 (1998a).
Kingswood SC, Kumamoto AT, Charter SJ, Aman RA, Ryder OA: Centric fusion polymorphisms in waterbuck (Kobus ellipsiprymnus). J Hered 89:96–100 (1998b).
Kingswood SC, Kumamoto AT, Charter SJ, Houck ML, Benirschke K: Chromosomes of the antelope genus Kobus (Artiodactyla, Bovidae): karyotypic divergence by centric fusion rearrangements. Cytogenet Cell Genet 91:128–133 (2000).
Kumamoto AT, Houck ML: Cytogenetic identification of a hybrid owl monkey, Aotus nancymaae x Aotus lemurinus griseimembra. J Zoo Wildl Med 32:130–133 (2001).
Kumamoto AT, Kingswood SC, Hugo W: Chromosomal divergence in allopatric populations of Kirks dik-dik, Madoqua-kirki (Artiodactyla, Bovidae). J Mammal 75:357–364 (1994).
Kumamoto AT, Kingswood SC, Rebholz WER, Houck ML: The chromosomes of Gazella bennettii and Gazella saudiya. Z Säugetierkd 60:159–169 (1995).
Kumamoto AT, Charter SJ, Kingswood SC, Ryder OA, Gallagher DS Jr: Centric fusion differences among Oryx dammah, O. gazella, and O. leucoryx (Artiodactyla, Bovidae). Cytogenet Cell Genet 86:74–80 (1999).
Lear TL, Houck ML, Zhang YW, Debnar LA, Sutherland-Smith MR, et al: Trisomy 17 in a bonobo (Pan paniscus) and deletion of 3q in a lowland gorilla (Gorilla gorilla gorilla): comparison with human trisomy 18 and human deletion 4q syndrome. Cytogenet Cell Genet 95:228–233 (2001).
Ma NS, Aquino R, Collins WE: Two new karyotypes in the Peruvian owl monkey (Aotus trivirgatus). Am J Primatol 9:333–341 (1985).
Mastromonaco GF, Coppola G, Crawshaw G, DiBerardino D, King WA: Identification of the homologue of the bovine Rob(1;29) in a captive gaur (Bos gaurus). Chromosome Res 12:725–731 (2004).
McClure HM, Belden KH, Pieper WA, Jacobson CB: Autosomal trisomy in a chimpanzee: resemblance to Down’s syndrome. Science 165:1010–1113 (1969).
Moore CM, Best RG: Chromosomal genetic disease: structural aberrations. Encyclopedia of Life Sciences, pp 1–8 (Nature Publishing Group (, 2001).
Moore CM, Harris CP, Abee CR: Distribution of chromosomal polymorphisms in three subspecies of squirrel monkeys (genus Saimiri). Cytogenet Cell Genet 53:118–122 (1990).
Moore CM, Leland MM, Brzyski RG, McKeand J, Witte SM, Rogers J: A baboon (Papio hamadryas) with an isochromosome for the long arm of the X. Cytogenet Cell Genet 82:80–82 (1998a).
Moore CM, McKeand J, Witte SM, Hubbard GB, Rogers J, Leland MM: Teratoma with trisomy 16 in a baboon (Papio hamadryas). Am J Primatol 46:323–332 (1998b).
Moore CM, Hubbard GB, Dick E, Dunn BG, Raveendran M, et al: Trisomy 17 in a baboon (Papio hamadryas) with polydactyly, patent foramen ovale and pyelectasis. Am J Primatol 69:1105–1118 (2007).
Muramatsu S, Shirai-Muramatsu M, Miyazaki H, Fukui E: Chromosome polymorphism found in the wild population of Japanese sika deer (Cervus Nippon). Chromosome Res 10 (suppl 1):19 (2002).
Myka JL, Lear TL, Houck ML, Ryder OA, Bailey E: Homologous fission event(s) implicated for chromosomal polymorphisms among five species in the genus Equus. Cytogenet Genome Res 102:217–221 (2003).
Nombela JJA, Murcia CR, Abaigar T, Vericad JR: GTG-banded karyotype of Gazella dama mhorr Bennett, 1833 – Cytogenetic relationship with other members of the subgenus Nanger. Z Säugetierkd 55:194–201 (1990).
Petit P, de Meurichy W: On the chromosomes of the okapi. Okapia johnstoni. Ann Genet 29:232–234 (1986).
Popescu PC: Chromosomes of the cow and bull, in: McFeely RA (ed): Domestic Animal Cytogenetics, pp 41–71 (Academic Press, SanDiego 1990).
Reddacliff GL, Halnan CRE, Martin ICA: Mosaic 35,X/36,XY karyotype and intersex in a red panda (Ailurus fulgens fulgens). J Wildl Dis 29:169–173 (1993).
Rejduch B, Slota E, Rozycki M, Koocielny M: Unusual chromosome number polymorphism in one litter of European wild pigs. Chromosome Res 10 (suppl 1):20 (2002).
Reyes FI, Osborn RG, Fuller GB, Hobson WC, Greenberg C, et al: Gonadal dysgenesis with X-monosomy in a cynomolgus monkey (Macaca fascicularis). Am J Primatol 22:51–51 (1990).
Robinson TJ, Elder FFB: Cytogenetics: its role in wildlife management and the genetic conservation of mammals. Biol Conserv 63:47–51 (1993).
Robinson WP, McFadden DE: Chromosomal genetic disease: numerical aberrations. Encyclopedia of Life Sciences, pp 1–7 (John Wiley & Sons Ltd (, 2002).
Rubes J, Pagacova E, Kopecna O, Kubickova S, Cernohorska H, et al: Centric fusion polymorphism and chromosomal aberrations in captive-born mountain reedbuck (Redunca fulvorufula). Cytogenet Genome Res 116:263–268 (2007).
Ruppenthal GC, Cafery SA, Goodlin BL, Sackett GP, Vigfusson NV, Peterson VG: Pigtailed macaques (Macaca nemestrina) with trisomy X manifest physical and mental retardation. Am J Ment Defic 87:471–476 (1983).
Ruppenthal GC, Moore ChM, Best RG, Walker-Gelatt CG, Delio PJ, Sackett GP: Trisomy 16 in a pigtailed macaque (M. nemestrina) with multiple anomalies and developmental delays. Am J Ment Retard 109:9–20 (2004).
Ryder OA: Chromosomal polymorphism in Equus hemionus. Cytogenet Cell Genet 21:177–183 (1978).
Ryder OA, Chemnick LG: Chromosomal and molecular evolution in Asiatic wild asses. Genetica 83:67–72 (1990).
Ryder OA, Epel NC, Benirschke K: Chromosome banding studies of the Equidae. Cytogenet Cell Genet 20:323–350 (1978).
Shi L, Yang F, Kumamoto A: The chromosomes of tufted deer (Elaphodus cephalophus). Cytogenet Cell Genet 56:189–192 (1991).
Shirai-Muramatsu M, Ikeda S, Ishida M, Miyazaki H, Matsui H, Muramatsu S: Comparative cytogenetic analyses among subspecies of wild-caught Japanese sika deer in Japan. Cytogenet Genome Res 106:17 (2004).
Suedmeyer WK, Houck ML, Kreeger J: Klinefelter syndrome (39,XXY) in an adult Siberian tiger (Panthera tigris altaica). J Zoo Wildl Med 34:96–99 (2003).
Svartman M, Vianna-Morgante AM: Karyotype evolution of marsupials: from higher to lower diploid numbers. Cytogenet Cell Genet 82:263–266 (1998).
Swartz KB, Sackett GP: Social preferences by and for pigtailed macaques (Macaca nemestrina) with trisomy 18. Am J Ment Retard 99:141–150 (1994).
Vadhanakul N, Tansatit M, Tunwattana W: Karyotype of a Thai gaur sire of Khao Kheow Open Zoo. J Thai Vet Med Assoc 54:39–48 (2003).
Vassart M, Greth A, Durand V, Cribiu EP: Chromosomal polymorphism in sand gazelles (Gazella subgutturosa marica). J Hered 84:478–481 (1993).
Vermeesch JR, de Meurichy W, Van Den Berghe H, Marynen P, Petit P: Differences in the distribution and nature of the interstitial telomeric (TTAGGG)n sequences in the chromosomes of the Giraffidae, okapai (Okapia johnstoni), and giraffe (Giraffa camelopardalis): evidence for ancestral telomeres at the okapi polymorphic rob(5;26) fusion site. Cytogenet Cell Genet 72:310–315 (1996).
Vigfusson NV, Dawson RJ, Jones JF, Shaw KJ, Lloyd MA, et al: Mosaic variegated trisomy (42,XY/43,XY, + variable) in a male pigtail macaque monkey. Cytogenet Cell Genet 42:154–158 (1986).
Wallace C, Fairall N: Chromosomal polymorphism in the impala. S Afr J Sci 63:482–486 (1967).
Wapner RJ, Lewis D: Genetics and metabolic causes of stillbirth. Semin Perinatol 26:70–74 (2002).
Ward OG, Miller RL, Johnson EH, Lucas JN, Meyne J: Identification of trisomy in Macaca fascicularis by fluorescence in situ hybridization with a human chromosome 13 DNA library. Hum Genet 94:247–251 (1994).
Weiss G, Weick RF, Knobil E, Wolman SR, Gorstein F: An X-O anomaly and ovarian dysgenesis in a rhesus monkey. Folia Primatol 19:24–27 (1973).
Whitehouse DB, Evans EP, Putt W, George AM: Karyotypes of the East African common zebra, Equus burchelli: centric fission in a pedigree. Cytogenet Cell Genet 38:171–175 (1984).
Wurster DH, Benirschke K: Chromosome studies in the superfamily Bovoidea. Chromosoma 25:152–171 (1968).
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