Sheep (OAR), goat (CHI) and cattle (BTA) R-banded chromosome preparations, obtained from synchronized cell cultures, were used to FISH-map leptin (LEP) and solute carrier family 26 member 2 (SLC26A2) genes on single chromosome bands. LEP maps on OAR4q32 and CHI4q32, being the first assignment of this gene to these two species. SLC26A2 maps on BTA7q24, OAR5q24 and CHI7q24. This gene, too, was assigned for the fist time to both sheep and goat chromosomes, while it was more precisely localized on a single chromosome band in cattle. Improved cytogenetic maps of BTA4/OAR4/CHI4 were constructed and compared with HSA7 revealing five main conserved segments and complex chromosome rearrangements, including a centromere repositioning, differentiating HSA7 and BTA4/OAR4/CHI4.

Brenig B, Baumgartner BG, Kriegesmann B, Haberman F, Fries R, Swalve HH: Molecular cloning, mapping and functional analysis of the bovine sulfate transporter SLC26a2 gene. Gene 319:161–166 (2003).
Briggs MD, Chapman KL: Pseudoachondroplasia and multiple epiphyseal dysplasia: mutation review, molecular interactions, and genotype to phenotype correlation. Hum Mutat 19:465–478 (2002).
Di Meo GP, Perucatti A, Gautier M, Hayes H, Incarnato D, Eggen A, Iannuzzi L: Chromosome localization of the 31 type I Texas bovine markers in sheep and goat chromosomes by comparative FISH-mapping and R-banding. Anim Genet 34:294–296 (2003).
Everts-van der Wind A, Larkin DM, Green CA, Elliot JS, Olmstead CA, Chiu R, Schein JE, Marra MA, Womack JE, Lewin HA: A high-resolution whole-genome cattle–human comparative map reveals details of mammalian chromosome evolution. Proc Natl Acad SciUSA 102:18526–18531 (2005).
Fietta P: Focus on leptin, a pleiotropic hormone. Minerva Med 96:65–75 (2005).
Gautier M, Hayes H, Bonsdorff T, Eggen A: Development of a comprehensive comparative radiation hybrid map of bovine chromosome 7 (BTA7) versus human chromosome 1 (HSA1), 5 (HSA5) and 19 (HSA19). Cytogenet Genome Res 102:25–31 (2003).
Hayes H: Chromosome painting with human chromosome-specific DNA libraries reveals the extent and distribution of conserved segments in bovine chromosomes. Cytogenet Cell Genet 71:168–174 (1995).
Hayes H, Elduque C, Gautier M, Schibler L, Cribiu E, Eggen A: Mapping of 195 genes in cattle and updated comparative map with man, mouse, rat and pig. Cytogenet Genome Res 102:16–24 (2003).
Iannuzzi L, Perucatti A, Di Meo GP, Schibler L, Incarnato D, Cribiu EP: Chromosomal localization of sixty autosomal loci in sheep (Ovis aries, 2n = 54) by fluorescence in situ hybridization and R-banding. Cytogenet Genome Res 103:135–138 (2003).
ISCNDB 2000: International System for Chromosome Nomenclature of Domestic Bovids. Di Berardino D, Di Meo GP, Gallagher DS, Hayes H, Iannuzzi L (co-ordinator) eds. Cytogenet Cell Genet 92:283–299 (2001).
Itoh T, Watanabe T, Ihara N, Mariani P, Beattie CW, Sugimoto Y, Takasuga A: A comprehensive radiation hybrid map of the bovine genome comprising 5593 loci. Genomics 85:413–424 (2005).
Kierstein G, Iannuzzi L, Silva A, Schneider MP, Baumgartner BG, Brenig B: Assignment of solute carrier family 26 (sulfate transporter), member 2 (SLC26a2) to river buffalo (Bubalus bubalis, 2n = 50) chromosome 9q26 (BBU9q26) by fluorescence in situ hybridisation and R-banding. Cytogenet Genome Res 103:202A (2003).
Markovich D: Physiological roles and regulation of mammalian sulfate transporters. Physiol Rev 81:1499–1533 (2001).
Ordovas L, Roy R, Zaragoza P, Hayes H, Eggen A, Rodellar C: Assignment of the solute carrier family 27 member 1 (SLC27A1) gene to bovine chromosome 7. Anim Genet 36:352–353 (2005).
Perucatti A, Floriot S, Di Meo GP, Soglia D, Rullo R, Maione S, Incarnato D, Eggen A, Sacchi P, Rasero R, Iannuzzi L: Comparative FISH-mapping of mucin 1, transmembrane (MUC1) among cattle, river buffalo, sheep and goat chromosomes: comparison between bovine chromosome 3 and HSA1. Cytogenet Genome Res 112:103–105 (2006).
Rossi A, Superti-Furga A: Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene (SLC26A2): 22 novel mutations, mutation review, associated skeletal phenotypes, and diagnostic relevance. Hum Mutat 17:159–171 (2001).
Vallinoto M, Schneider MPC, Silva A, Iannuzzi L, Brenig B: Molecular cloning and analysis of the swamp and river buffalo leptin gene. Anim Genet 35:462–463 (2004).
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