We previously revealed similarity in gene expression patterns between human brain and testis, based on digital differential display analyses of 760 human Unigenes. In the present work, we reanalyzed the gene expression data in many tissues of human and mouse for a large number of genes almost covering the respective whole genomes. The results indicated that both in human and in mouse, the gene expression profiles exhibited by brain, cerebellum and testis are most similar to each other compared with other tissues.    

Bolstad BM, Irizarry RA, Astrand M, Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19:185–193 (2003).
Caceres M, Lachuer J, Zapala MA, Redmond JC, Kudo L, Geschwind DH, Lockhart DJ, Preuss TM, Barlow C: Elevated gene expression levels distinguish human from non-human primate brains. Proc Natl Acad Sci USA 100:13030–13035 (2003).
Enard W, Khaitovich P, Klose J, Zollner S, Heissig F, Giavalisco P, Nieselt-Struwe K, Muchmore E, Varki A, Ravid R, Doxiadis GM, Bontrop RE, Pääbo S: Intra- and interspecific variation in primate gene expression patterns. Science 296:340–343 (2002).
Enard W, Fassbender A, Model F, Adorján P, Pääbo S, Olek A: Differences in DNA methylation patterns between humans and chimpanzees. Curr Biol 14:R148–R149 (2004).
Franchimont P, Chari S, Demoulin A: Hypothalamus-pituitary-testis interaction. Reprod Fertil 44:335–350 (1975).
Genazzani AR, Gastaldi M, Bidzinska B, Mercuri N, Genazzani AD, Nappi RE, Segre A, Petraglia F: The brain as a target organ of gonadal steroids. Psychoneuroendocrinology 17:385–390 (1992).
Gu J, Gu X: Induced gene expression in human brain after the split from chimpanzee. Trends Genet 19:63–65 (2003).
Guo J, Zhu P, Yu L, Gu X: In silico analysis indicates a similar gene expression pattern between human brain and testis. Cytogenet Genome Res 103:58–62 (2003).
Hsieh WP, Chu TM, Wolfinger RD, Gibson G: Mixed-model reanalysis of primate data suggests tissue and species biases in oligonucleotide-based gene expression profiles. Genetics 165:747–757 (2003).
Jones RE: Human Reproductive Biology, 2nd edition (Academic Press, San Diego 1997).
Marquès-Bonet T, Cáceres M, Bertranpetit J, Preuss TM, Thomas JW, Navarro A: Chromosomal rearrangements and the genomic distribution of gene-expression divergence in humans and chimpanzees. Trends Genet 20:524–529 (2004).
Sirotnak FM, She Y, Khokhar NZ, Hayes P, Gerald W, Scher HI: Microarray analysis of prostate cancer progression to reduced androgen dependence: studies in unique models contrasts early and late molecular events. Mol Carcinog 41:150–163 (2004).
Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, Wiltshire T, Orth AP, Vega RG, Sapinoso LM, Moqrich A, et al: Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci USA 99:4465–4470 (2002).
Sun S, Ting CT, Wu CI: The normal function of a speciation gene, Odysseus, and its hybrid sterility effect. Science 305:81–83 (2004).
Wilda M, Bachner D, Zechner U, Kehrer-Sawatzki H, Vogel W, Hameister H: Do the constraints of human speciation cause expression of the same set of genes in brain, testis, and placenta? Cytogenet Cell Genet 91:300–302 (2000).
Yaginuma T, Kigawa T, Kobayashi T, Kobayashi T: Further studies on the hypothalamo-pituitary testicular axis of the rat in the neonatal period. J Endocrinol 145:473–474 (1969).
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.