The term “chromosomics” is introduced to draw attention to the three-dimensional morphological changes in chromosomes that are essential elements in gene regulation. Chromosomics deals with the plasticity of chromosomes in relation to the three-dimensional positions of genes, which affect cell function in a developmental and tissue-specific manner during the cell cycle. It also deals with species-specific differences in the architecture of chromosomes, which has been overlooked in the past. Chromosomics includes research into chromatin-modification-mediated changes in the architecture of chromosomes, which may influence the functions and life-spans of cells, tissues, organs and individuals. It also addresses the occurrence and prevalence of chromosomal gaps and breaks.   

Baumgartner M, Dutrillaux B, Lemieux N, Lilienbaum A, Paulin D, Viegas-Pequignot E: Genes occupy a fixed and symmetrical position on sister chromatids. Cell 64:761–766 (1991).
Borden J, Manuelidis L: Movement of the X chromosome in epilepsy. Science 23:1687–1691 (1988).
Bridger JM, Boyle S, Kill IR, Bickmore WA: Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts. Curr Biol 10:149–152 (2000).
Chevret E, Volpi EV, Sheer D: Mini review: Form and function in the human interphase chromosome. Cytogenet Cell Genet 90:13–21 (2000).
Claussen U, Michel S, Mühlig P, Westermann M, Grummt U-W, Kromeyer-Hauschild K, Liehr T: Demystifying chromosome preparation and the implications for the concept of chromosome condensation during mitosis. Cytogenet Genome Res 98:136–146 (2002).
Cremer T, Cremer C: Chromosome territories, nuclear architecture and gene regulation on mammalian cells. Nat Rev Genet 32:292–300 (2001).
Dietzel S, Schiebel K, Little G, Delemann P, Rappold GA, Eils R, Cremer C, Cremer T: The 3D positioning of ANT2 and ANT3 genes within female X chromosome territories correlates with gene activity. Exp Cell Res 252:363–375 (1999).
Gerlich D, Beaudouin J, Kalbfuss B, Daigle N, Eils R, Ellenberg J: Global chromosome positions are transmitted through mitosis in mammalian cells. Cell 21:751–764 (2003).
Heng HHQ, Krawetz SA, Lu W, Bremer S, Liu G, Ye CJ: Re-defining the chromatin loop domain. Cytogenet Cell Genet 93:155–161 (2001).
Hliscs R, Mühlig P, Claussen U: The nature of G-bands analyzed by chromosome stretching. Cytogenet Cell Genet 79:162–166 (1997).
Holmquist GP: Chromosome bands, their chromatin flavors and their functional features. Am J Hum Genet 51:17–37 (1992).
Jenuwein T, Allis CD: Translating the histone code. Science 293:1074–1080 (2001).
Kipling D, Davis T, Ostler EL, Faragher RGA: What can progeroid syndromes tell us about human aging? Science 305:1426–1431 (2004).
Kopka ML, Yoon C, Goodsell D, Pjura P, Dickerson RE: The molecular origin of DNA-drug specificity in netropsin and distamycin. Proc Natl Acad Sci USA 82:1376–1380 (1985).
Lachner M, O’Sullivan RJ, Jenuwein T: An epigenetic road map for histone lysine methylation. J Cell Sci 116:2117–2124 (2003).
Lemke J, Claussen J, Michel S, Chudoba I, Mühlig P, Westermann M, Sperling K, Rubtsov N, Grummt U-W, Ullmann P, Kromeyer-Hauschild K, Liehr T, Claussen U: The DNA-based structure of human chromosome 5 in interphase. Am J Hum Genet 71:1051–1059 (2002).
Mayer W, Niveleau A, Walter J, Fundele R, Haaf T: Demethylation of the zygote paternal genome. Nature 403:501–502 (2000).
Paulson JR, Laemmli UK: The structure of histone-depleted metaphase chromosomes. Cell 12:817–828 (1977).
Porschke D: Dynamics of DNA condensation. Biochemistry 23:4821–4828 (1984).
Porschke D: Nature of protamine-DNA complexes – a special type of ligand binding co-operativity. J Mol Biol 222:423–433 (1991).
Reichert W, Hansmann I, Röhrborn G: Chromosome anomalies in mouse oocytes after irradiation. Humangenetik 28:25–38 (1975).
Savage JRK: On the nature of visible chromosomal gaps and breaks. Cytogenet Genome Res 104:46–55 (2004).
Spector DL: The dynamics of chromosome organization and gene regulation. Annu Rev Biol 72:573–608 (2003).
Strick TR, Allemand JF, Bensimon D, Bensimon A, Croquette V: The elasticity of a single supercoiled DNA molecule. Science 271:1835–1837 (1996).
van Holde KE: Chromatin (Springer Verlag, New York 1988).
Volpi EV, Chevret E, Jones T, Vatcheva R, Williamson J, Beck S, Campbell RD, Goldsworthy M, Powis SH, Ragoussis J, Trowsdale J, Sheer D: Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei. J Cell Sci 113:1565–1576 (2000).
Weise A, Starke H, Heller A, Claussen U, Liehr T: Evidence for interphase DNA decondensation transverse to the chromosome axis: A multicolor banding analysis. Int J Mol Med 9:359–361 (2002).
Wolffe AP: Chromatin: Structure and Function (Academic Press, San Diego 1998).
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