Es wird ein Tiermodell zur Erzeugung eines akuten Leberversagens am Schwein vorgestellt. Narkosedurchführung und operatives Vorgehen werden detailliert angegeben. Unter Verwendung einer hydrauhsch gesteuerten Gefäβklemme läβt sich die Arteria hepatica propia sicher extrakorporal verschlieβen. Den Abschluβ der Experimente bildet eine Szintigraphie von Leber und Milz nach 24 Stunden. Die Szintigramme zeigen eine Restperfusion des Lobus caudatus über die Vena cava inferior. Ausgewählte bio-chemische Parameter und der klinische Verlauf belegen das Leberversagen bei den Tieren. Das Tiermodell ist für die Bewertung der Effektivität von Leberunterstützungssystemen geeignet.

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