Background: Umbilical metastasis, known previously as Sister Mary Joseph’s nodule, is a well-known intraabdominal malignancy. Hepatocellular carcinoma presents rarely as Sister Mary Joseph’s nodule, and umbilical metastasis after liver transplantation has not been reported. Case Report: We present a 59-year-old patient with hepatitis C-related liver cirrhosis combined with hepatocellular carcinoma who underwent cadaveric liver transplantation. The patient exhibited an umbilical nodule that had developed rapidly within 2 months after the transplantation. Umbilical metastasis of hepatocellular carcinoma was diagnosed by excision biopsy. Conclusion: The tumor manipulation, engorgement of the umbilical vein, preexisting umbilical hernia, immunosuppressive agents, or a combination of factors, may have induced the umbilical metastasis.

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