Brunner’s gland hyperplasia is usually asymptomatic and found as an incidental finding after biopsy during upper gastrointestinal endoscopy. Symptomatic patients mostly present with either upper gastrointestinal bleed manifesting as melena or anemia, or with subacute intestinal obstruction manifesting as intractable nausea and vomiting. Gastric outlet obstruction secondary to Brunner’s gland hyperplasia has been rarely reported. Conservative management with naso-gastric suction provides temporary improvement in symptoms. Most patients have near complete resolution of symptoms after resection of the culprit lesion.

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