About 5–10% of colon cancers belong to autosomal-dominantly inherited susceptibilities such as familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer and the hamartoma polyposis syndromes. Considerable progress has been made towards the understanding of the molecular basis leading to the hereditary cancer syndromes, which is of considerable value for the aim of screening, prevention and therapy. However, most of the familial aggregations of colorectal cancer cannot be attributed to these syndromes. This gap in the understanding of familial carcinogenesis can only be overcome through a structured collaboration between gastroenterologists, oncologists, geneticists, basic researchers and surgeons.

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© 2000 S. Karger GmbH, Freiburg
2000
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