A rational stepwise diagnostic approach is a central prerequisite for sufficient treatment of abdominal sepsis. Physical examination results in a substantial grading of absent, local or general tenderness and guarding. If guarding is absent, a stepwise and efficient diagnostic approach is applied according to pain intensity and location. In these cases diagnostic laparoscopy is rarely required. In cases of local tenderness, however, diagnostic and often therapeutic laparoscopy plays a key role when extraabdominal origin of pain and diseases prone to medical treatment have been ruled out. In some cases laparotomy can also be avoided by interventional treatment. In patients with generalized guarding we differentiate between ‘spontaneous’ symptoms and cases of postoperative peritonitis. If signs of generalized abdominal sepsis occur without previous surgery, laparotomy should be performed with minimal diagnostic delay in order to obtain rapid source control. The main diagnostic pitfalls result from postoperative peritonitis. In some cases extensive diagnostic means have to be applied to select the optimal therapeutic procedure and ideal timing. In these cases computed tomography (spiral CT) may prove especially beneficial when it is combined with intravenous, oral or rectal application of contrast medium. Spiral CT with i. v. contrast medium enables the detection of ischemic bowel segments. In sigma diverticulitis quite often only CT with i. v. or rectal application of contrast agent allows for adequately staged therapy. Diagnostic problems in postoperatively persisting or recurrent peritonitis can be reduced by means of a staged relaparotomy.

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