Apatient with complete paraplegia due to Paget''s disease of bone, which had failed to respond to any other treatment, was subjected to a trial treatment with actinomycin D administered in varying amounts during three series at irregular intervals. By the end of treatment, complete clinical recovery had been obtained, with the patient fully ambulant, and there had been an almost complete normalization of laboratory values of serum alkaline phosphatase and calcium and of urinary hydroxyproline. Follow-up six months later showed no recurrence of the clinical signs; the laboratory levels had remained almost constant, with the exception of hydroxyproline, which was increased. The findings of other workers in this field and the possible mechanism of action of actinomycin D are briefly noted and discussed.

Keywords:
Paget's disease, Actinomycin D, Paraplegia
This content is only available via PDF.
© 1974 S. Karger AG, Basel
1974
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.