Apatient with complete paraplegia due to Paget''s disease of bone, which had failed to respond to any other treatment, was subjected to a trial treatment with actinomycin D administered in varying amounts during three series at irregular intervals. By the end of treatment, complete clinical recovery had been obtained, with the patient fully ambulant, and there had been an almost complete normalization of laboratory values of serum alkaline phosphatase and calcium and of urinary hydroxyproline. Follow-up six months later showed no recurrence of the clinical signs; the laboratory levels had remained almost constant, with the exception of hydroxyproline, which was increased. The findings of other workers in this field and the possible mechanism of action of actinomycin D are briefly noted and discussed.

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