...Shanshan Chen; Ruyi Cong; Yongbo Chen; Xiaoliang Li; Xiaoyu Zhang; Guohua Wang; Xiuyu Pang; Weijia Xing; Youxin Wang; Xizhu Xu Introduction: Several observational studies have indicated that polyunsaturated fatty acid serum levels (PUFAs) are associated with vascular dementia (VaD...

...Hannes Holm; Katarina Nägga; Erik D. Nilsson; Fabrizio Ricci; Eduardo Cinosi; Olle Melander; Oskar Hansson; Erasmus Bachus; Martin Magnusson; Artur Fedorowski Background: Increased somatostatin plasma concentration has been found in patients with vascular dementia. However, it is unknown whether...

..., 12 with progressive supranuclear palsy, 9 with vascular dementia (VaD), and 16 controls, were examined. On a horizontal section of a cerebellar hemisphere examined with 7.0-tesla MRI, the number CCeMBs and CCeMIs were compared between the different disease groups and the control group. The MRI...

..., there is a dearth of information regarding the public health magnitude of stroke. The aim of the Fogarty-Mexico cohort was to assess the prevalence of vascular behavioral and cognitive disorders, ranging from mild vascular cognitive impairment (VCI) to vascular dementia (VaD), in a cohort of acute first-ever...

... to vascular cognitive impairment and vascular dementia. Nonetheless, few pharmacological studies have addressed vascular cognitive impairment after stroke. We assessed the safety of long-term administration and its possible efficacy of citicoline in preventing poststroke cognitive decline in patients...

.... Atherosclerosis Vascular risk factors Cognitive function Dementia Alzheimer’s disease Vascular dementia Cohort studies Subjects were participants in the Tromsø study, a longitudinal population-based study in the municipality of Tromsø, Norway [ 12 ]. In 2001/2002, all 6,982 subjects who attended...

... to in the content or advertisements. Vascular dementia Vascular cognitive impairment White matter lesions Lacunar infarcts Prognosis The relationship between cerebrovascular diseases (CVDs) and cognitive decline is very complex. The complexity of the topic and its limited understanding...

...Hiroki Kato; Takuya Yoshikawa; Naohiko Oku; Masao Imaizumi; Masashi Takasawa; Yasuyuki Kimura; Katsufumi Kajimoto; Makiko Tanaka; Kazuo Kitagawa; Masatsugu Hori; Jun Hatazawa Background: Subcortical ischemic vascular dementia (SVD) caused by small-artery disease is a major cause of dementia...

... with cognitive performance. Conclusions: In patients with lacunar stroke, presence of leukoaraiosis is associated with worse performance in multiple cognitive domains. These findings suggest lacunar infarcts plus leukoaraiosis is a common etiology for vascular dementia. Fig. 1 Distribution...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Stroke prevention Transient ischemic attack Aspirin Extended-release dipyridamole Clopidogrel Telmisartan Stroke severity Vascular dementia Blood pressure Original Paper...

...Eduardo Martínez-Vila; Manuel Murie-Fernández; Jaime Gállego Pérez-Larraya; Pablo Irimia Vascular dementia (VaD) is the second most common form of dementia after Alzheimer’s disease (AD), and one of the major causes of mental and physical disability in developed countries...

.... Poststroke dementia Alzheimer’s disease Vascular dementia White matter changes The association between stroke and dementia is frequent. Poststroke dementia (PSD) has been an emerging field of research over the last decade, the term ‘PSD’ including any type of dementia occurring after a stroke...

...Gustavo C. Román Brain injury from ischemic or hemorrhagic cerebrovascular disease (CVD) produces decline in cognitive functions and vascular dementia (VaD). Likewise, CVD may cause VaD from hypoperfusion of susceptible brain areas. CVD may also worsen degenerative dementias such as Alzheimer’s...

... and physiological effects of these widely distributed proteases and describe the genetic background and regulation pathways. In particular, we discuss the role of matrix metalloproteinases in vascular remodelling concerning ischaemic stroke, brain haemorrhage, vascular dementia, carotid artery plaques and cerebral...

... months among patients diagnosed with vascular dementia (VaD). Methods: 30 patients diagnosed with VaD, based upon NINDS-AIREN and DSM-IV criteria, were randomized and treated with either 500 mg of citicoline or placebo twice per day. Patients were assessed at baseline, and at 6, and 12 months...

... domains in vascular dementia (VaD) remains unclear. Methods: We compared the sensitivity and specificity of two recommended cutoff scores of the DRS. Thirty-eight patients diagnosed with VaD participated in the current study. Results: The original recommendations resulted in poor sensitivity for the DRS...

...H.J. Möbius; A. Stöffler Although criteria for the diagnosis of vascular dementia (VaD) are established, the diagnostic concept is still controversial and there is no regulatory guidance for clinical drug development. Clinical trials in VaD present a number of pitfalls and challenges and, so far...

... to in the content or advertisements. Amyloid Congophilic material Angiopathy Hereditary β-Amyloid precursor protein Vascular dementia Stroke Transgenic mouse Cerebral amyloid angiopathy (CAA) is defined by deposition of congophilic material in the walls of small blood vessels in the cerebral...

...Timo Erkinjuntti Vascular dementia (VaD) incorporates different vascular mechanisms and changes in the brain, and has different causes and clinical manifestations. Current criteria for VaD select an aetiologically and clinically heterogeneous group and this definitional heterogeneity has affected...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Alzheimer’s disease Cerebral amyloid angiopathy Hyalinosis Small vessel disease Cerebrovascular degeneration Vascular dementia The underlying processes...