... among participants of the pilot phase, Intensive Blood Pressure (BP) Reduction in Acute Cerebral Hemorrhage Trial (INTERACT1). Methods: INTERACT1 was an open randomized trial of early intensive (target systolic BP <140 mm Hg) compared with contemporaneous guideline-recommended BP lowering in 404...

...Fahad Javaid Siddiqui; Narayanaswamy Venketasubramanian; Edwin Shih-Yen Chan; Christopher Chen Background: Subsequent to a pooled analysis of 2 trials, several more studies have been published assessing the benefit of MLC601 in stroke patients. Hence, it is timely to conduct an updated meta...

...E.L.L.M. De Schryver The ESPRIT trial addresses the problem that aspirin, the standard therapy for secondary prevention of vascular complications after a transient ischaemic attack (TIA) or ischaemic stroke of arterial origin, reduces the risk of serious vascular events by only about 13...

...J.W. Norris; L.H. LeBrun; B.A. Anderson Numerous animal studies have indicated a beneficial effect of nimodipine in experimental cerebral infarction when the drug is given just before or within 1 h of the cerebral ischaemia. We performed a randomised, placebo-controlled trial, starting within 48 h...