... arrival thereby increasing eligibility for time-sensitive stroke treatments. Whether higher stroke preparedness is associated with higher tissue plasminogen activator (tPA) treatment rates is however uncertain. We therefore set out to determine the contribution of stroke preparedness to regional variation...

... scale for tissue plasminogen activator (t-PA) intravenous therapy (TOPSPIN) for triaging patients with ischemic stroke and especial indications for intravenous t-PA therapy in December 2006; this scale comprises 5 items including consciousness, atrial fibrillation, language disorder, disturbance...

... (ED) may differ according to the severity of a patient’s stroke symptoms. We investigated whether the time from arrival at ED to various care steps differed between patients with minor and non-minor stroke who were treated with intravenous tissue plasminogen activator (IV tPA). Methods: We included...

... patients with the following criteria were included: (1) referred to a comprehensive stroke center for acute ischemic stroke with proven BAO and CTA or MRA; (2) angiographically confirmed BAO; (3) treated with or without tissue plasminogen activator (t-PA); (4) treated with MET using the latest generation...

..., instructions or products referred to in the content or advertisements. Cerebral infarction Tissue plasminogen activator Cerebral hemorrhage Acute stroke outcome Thrombolytic therapy with intravenous alteplase (recombinant tissue-type plasminogen activator) at a dose of 0.9 mg/kg improves...

... median OTT, but fewer patients received intravenous recombinant tissue plasminogen activator (rt-PA), and more rescue therapies were utilized to achieve high recanalization. Good collateral flow rate was not reported in NASA [ 19 ], hence we could not compare this important factor; however, the sICH rate...

... was to clarify the association between very early rehabilitation and outcomes in acute ischemic stroke patients who received tissue plasminogen activator, using a national inpatient database in Japan. Methods: We identified patients who were admitted to acute-care hospitals with ischemic stroke and were treated...

..., the clinical meaning of changes in HV is yet to be clarified. Here, we investigated serial changes to HV in patients with AIS who received tissue plasminogen activator (t-PA) therapy. Methods: We studied t-PA patients presenting with HV on FLAIR in the middle cerebral artery territory. Patients underwent brain...

... Haan RJ, Nederkoorn PJ: Safety and functional outcome of thrombolysis in dissection-related ischemic stroke: a meta-analysis of individual patient data. Stroke 2011;42:2515-2520. 9. Doijiri R, Yokota C, Suzuki R, Toyoda K, Minematsu K: Intravenous recombinant tissue plasminogen activator...

... tissue plasminogen activator (rt-PA) therapy and to clarify the effect of END on 3-month outcomes. Methods: A retrospective, multicenter, observational study was conducted in 10 stroke centers in Japan. A total of 566 consecutive stroke patients [211 women, 72 ± 12 years old, the median initial NIH...

... prospectively studied all consecutive acute ischemic stroke patients treated with intravenous tissue plasminogen activator (tPA) in our stroke unit between January 2008 and December 2010. Patients treated within 0– 4.5 h were treated according to non-contrast CT (NCCT) criteria. Beyond 4.5 h, patients received...

... additional variables into the statistical model. Table 2 Factors independently associated with poor outcome at 90 days Acute stroke CT Leukoaraiosis Outcome Tissue plasminogen activator Thrombolysis Intracranial large artery occlusion (ILAO) in the anterior circulation accounts...

... this work. References 1. The National Institute of Neurological Disorders and Stroke rtPA Stroke Study Group: Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581-1587. 2. Adams HP Jr, del Zoppo G, Alberts MJ, et al, American Heart Association, American Stroke...

... hyperintensity with hemorrhage was then tested alongside established predictors (very low cerebral blood volume (VLCBV) and diffusion (DWI) lesion volume) in logistic regression analysis. Results: There were 49 patients with pre-treatment FLAIR imaging (38 received tissue plasminogen activator (tPA), 5 developed...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Tissue plasminogen activator Cerebral infarction Intracerebral hemorrhage Magnetic resonance imaging Hemorrhagic transformation (HT) following acute cerebral...

...) treated in 2008 were registered from 68 medical centers in Japan. Mean age on admission was 74.1 ± 12.2 years (range 7–100 years). The first treatment was conservative therapy in 68%, intravenous tissue plasminogen activator (IV-tPA) in 21%, EVT in 9%, and combined IV-tPA + EVT in 2%. EVT mainly comprised...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ischemic stroke Tissue plasminogen activator Overweight Clinical outcome...

...Bejoy Machumpurath; Stephen M. Davis; Bernard Yan Background: Treatment with tissue plasminogen activator (tPA) is associated with improved outcome in acute ischemic stroke. Of note, a proportion of patients demonstrate rapid and significant neurological recovery within 24 h. This has previously...

...C. Blinzler; L. Breuer; H.B. Huttner; P.D. Schellinger; S. Schwab; M. Köhrmann Background: Recombinant tissue plasminogen activator (rt-PA) is the only approved specific therapy for acute ischemic stroke. This study analyzes demographic and clinical characteristics of patients with early complete...

..., instructions or products referred to in the content or advertisements. Emergency medical service Prehospital stroke care Prehospital stroke scale Tissue plasminogen activator Acute stroke In the case of stroke, a common concept is that ‘time is brain’; that is, acute stroke therapy was highly...