... tool, considering the full spectrum of radiological brain health including small vessel disease parameters, is currently lacking. Furthermore, large-scale characterization of preexisting radiological brain health may elucidate novel phenotypes. This study aims (1) to characterize imaging manifestations...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Small subcortical infarction Small vessel disease Magnetic resonance imaging Early neurological deterioration Cardioembolic stroke...

...; Philippe Lyrer; Stefan T. Engelter; Nils Peters Introduction: Measures of cerebral small vessel disease (cSVD), such as white matter hyperintensities (WMH) and cerebral microbleeds (CMB), are associated with an unfavorable clinical course in stroke patients on oral anticoagulation (OAC) for atrial...

...). Microinfarcts Acute ischemic stroke Embolism Small vessel disease Magnetic resonance imaging Cerebral microinfarcts (CMIs) are small lesions of presumed ischemic etiology, which are common postmortem findings in the aged human brain [1]. In the context of Alzheimer’s disease or vascular dementia [2...

... the neuropsychological features of the very early stage of cognitive impairment with cerebral small vessel disease (CSVD) and to elucidate the cognitive differences among CSVD subtypes. Methods: A comprehensive neuropsychological test battery was applied to nondemented subjects scoring below the cutoff point 26...

...Yanjing Lu; Yifan Li; Qian Feng; Rong Shen; Hao Zhu; Hua Zhou; Zhong Zhao Background: Altered white matter brain networks have been extensively studied in cerebral small vessel disease (SVD). However, there exists currently a deficiency of comprehending the performance of changes within...

... suggestive of cerebral small vessel disease (SVD) on the evolution of cognitive performances after an ischemic stroke (IS). Methods: We studied patients with a supratentorial IS recruited consecutively to a prospective monocentric longitudinal study. A cognitive assessment was performed at baseline, 3 months...

...Laurien Onkenhout; Nadine Appelmans; L. Jaap Kappelle; Dineke Koek; Lieza Exalto; Jeroen de Bresser; Geert Jan Biessels; on behalf of the Utrecht VCI Study Group Background: Cerebral small vessel disease (SVD) lesions on MRI are common in patients with cognitive impairment. It has been suggested...

... the cornerstone in the perspective to better delimiting the boundaries of BAD as a nosological entity. Small vessel disease Intracranial atherosclerotic diseases Acute ischemic stroke Vascular risk factors Advanced MRI Fig. 3 HR MRI findings of BAD-related infarct and branch atheromatous plaque...

...Gillian M. Potter; Francesca M. Chappell; Zoe Morris; Joanna M. Wardlaw Background: Perivascular spaces (PVS) are an important component of cerebral small vessel disease (SVD), several inflammatory disorders, hypertension and blood-brain barrier breakdown, but are difficult to quantify. A recent...

...Stephen D.J. Makin; F.A.B. Cook; Martin S. Dennis; Joanna M. Wardlaw Background: The small vessel disease (SVD) that appears in the brain may be part of a multisystem disorder affecting other vascular beds such as the kidney and retina. Because renal failure is associated with both stroke and white...

..., their risk factors, radiological features and clinical relevance have been poorly evaluated in CADASIL (cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy), a unique model to investigate the pathophysiology of ischemic small-vessel disease. The purpose of this study...

...Leonardo Pantoni; Fabio Fierini; Anna Poggesi Background: Thrombolytic treatment is of proven benefit in acute ischemic stroke. The term cerebral small vessel disease (SVD) refers to a group of pathological processes affecting the small arteries, arterioles, venules and capillaries of the brain...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cohort study Prognosis Small vessel disease Stroke Stroke classification Ischemic stroke can have multiple causes. Among the most frequent causes are large-vessel...

...Jian Hui Fu; Yang Kun Chen; Xiang Yan Chen; Vincent Mok; Ka Sing Wong Background and Purposes: Until now, limited data are available about the potential effect of coexisting small vessel disease (SVD) on the long-term outcome of stroke patients with intracranial large artery atherosclerosis (ILAA...

..., education and medial temporal lobe atrophy. Conclusions: SIVD, as a manifestation of cerebral small vessel disease, is related to progressive cognitive impairment and a considerable risk of developing dementia. SIVD seems to specifically contribute to the deterioration of psychomotor speed, executive...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Subcortical ischemic vascular disease Small vessel disease White matter changes...

... a case-control design. Methods: 197 stroke patients were divided according to modified TOAST criteria (small vessel disease, large vessel disease, hemorrhagic stroke and asymptomatic carotid artery stenosis) and compared to 143 controls. Clinical data like age, sex, risk factors and diagnostic results...

... hypertensive target organ damage. This study was conducted to better delineate the relationships between 24-hour BP measurements, LI/WML and small vessel disease cognitive impairment/vascular dementia (CI/VD). Methods: Two hundred patients with first-time symptomatic LI were examined with 24-hour BP monitoring...

...Martin Dichgans Mutations in Notch3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited small vessel disease leading to subcortical strokes and vascular dementia. The phenotypic presentation is variable but remarkable...