... on mechanisms of cerebral oedema. The compound normalizes peri-infarct neuronal excitability and blocks the rise of peri-infarct extracellular concentration of glutamate. Lubeluzole downregulates the nitric oxide synthase (NOS) pathway leading to neurotoxicity and neuronal death. NOS pathway modulation may...

... on mechanisms of cerebral oedema. The compound normalizes peri-infarct neuronal excitability and blocks the rise of peri-infarct extracellular concentration of glutamate. Lubeluzole downregulates the nitric oxide synthase (NOS) pathway leading to neurotoxicity and neuronal death. NOS pathway modulation may...

..., is significantly impaired in patients with cardiovascular risk factors. Importantly, we found that patients with lacunar infarctions do not show any additional impairment of cerebral endothelial function. Cerebrovascular reactivity to L- arginine Lacunar infarction Nitric oxide Nitric oxide synthase...

...B. Rosengarten; R.T. Schermuly; R. Voswinckel; M.G. Kohstall; H. Olschewski; N. Weissmann; W. Seeger; M. Kaps; F. Grimminger; H.A. Ghofrani Background: Prostaglandins and nitric oxide play a pivotal role in the regulation of macro- and microcirculatory blood flow distribution. Interference...

..., and it remains unclear how BP should be managed in acute stroke. We assessed, in a double-blind randomised controlled trial, whether the nitric oxide (NO) donor glyceryl trinitrate (GTN, a known systemic and cerebral vasodilator), would lower BP and alter platelet function. Methods: Thirty-seven patients...

... of proinflammatory cytokines early after onset of symptoms. IL-1β, one of these cytokines, stimulates the production of nitric oxide (NO), a potent inflammatory mediator. The aim of the present study was to investigate the intrathecal levels of nitrate, one of the main metabolites of NO in acute stroke and to relate...

...R.J. Butterworth; A. Cluckie; S.H.D. Jackson; M. Buxton-Thomas; P.M.W. Bath Acute ischaemic stroke is characterised by reductions in local cerebral blood flow (CBF) and activation of circulating platelets and leucocytes. Nitric oxide is a vasodilator and can inhibit these circulating cells. The aim...