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Keywords: NeuroAiD
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Journal Articles
Subject Area:
Cardiovascular System
,
Karger e-Journal Backfile Collection 2023
,
Neurology and Neuroscience
Christopher Li Hsian Chen, Yogesh Pokharkar, Narayanaswamy Venketasubramanian, for the CHIMES and CHIMES-E Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2023) 52 (2): 160–165.
Published Online: 02 May 2023
... Clinical trial MLC601 MLC901 NeuroAiD NIHSS Functional recovery Motor impairment Stroke Stroke most often affects motor function, with hemiparesis and motor recovery being the most studied of all stroke impairments [ 1 ]. However, studies of the natural history of stroke mainly measure...
Journal Articles
Narayanaswamy Venketasubramanian, Rajesh B. Moorakonda, Qingshu Lu, Christopher L.H. Chen, On behalf of the CHIMES Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2020) 49 (2): 192–199.
Published Online: 03 March 2020
.... However, an extensive analysis of safety data could demonstrate beneficial results in terms of effectiveness by reducing serious adverse events (SAEs), and their unfavourable clinical impact on the study population. We aimed to conduct an exploratory analysis of the CHInese Medicine Neuroaid Efficacy...
Journal Articles
Nijasri C. Suwanwela, Christopher L.H. Chen, Chun Fan Lee, Sherry H. Young, San San Tay, Thirugnanam Umapathi, Annabelle Y. Lao, Herminigildo H. Gan, Alejandro C. Baroque II, Jose C. Navarro, Hui Meng Chang, Joel M. Advincula, Sombat Muengtaweepongsa, Bernard P.L. Chan, Carlos L. Chua, Nirmala Wijekoon, H. Asita de Silva, John Harold B. Hiyadan, Ka Sing Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Narayanaswamy Venketasubramanian, CHIMES-E Study Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2018) 46 (1-2): 82–88.
Published Online: 05 September 2018
... of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional outcomes after stroke. Methods: Data from the CHInese Medicine NeuroAiD Efficacy on Stroke (CHIMES) and CHIMES-Extension (CHIMES-E) studies were analyzed. CHIMES-E was a 24-month follow-up...
Journal Articles
Narayanaswamy Venketasubramanian, Chun Fan Lee, Sherry H. Young, San San Tay, Thirugnanam Umapathi, Annabelle Y. Lao, Herminigildo H. Gan, Alejandro C. Baroque II, Jose C. Navarro, Hui Meng Chang, Joel M. Advincula, Sombat Muengtaweepongsa, Bernard P.L. Chan, Carlos L. Chua, Nirmala Wijekoon, H. Asita de Silva, John Harold B. Hiyadan, Nijasri C. Suwanwela, K.S. Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Christopher L.H. Chen, for the CHIMES-E Study Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2017) 43 (1-2): 36–42.
Published Online: 15 November 2016
.... Asita de Silva; John Harold B. Hiyadan; Nijasri C. Suwanwela; K.S. Lawrence Wong; Niphon Poungvarin; Gaik Bee Eow; Christopher L.H. Chen; for the CHIMES-E Study Investigators Background: The Chinese Medicine NeuroAiD Efficacy on Stroke recovery - Extension (CHIMES-E) study is among the few acute stroke...
Journal Articles
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2016) 42 (1-2): 139–154.
Published Online: 22 April 2016
... for statistical analysis. Ischemic stroke Angiogenesis MLC601/901 NeuroAid Blood brain barrier Neurological deficits Recovery Although stroke is associated with high mortality and serious long-term disability, therapeutic options for clinical management remain quite limited. In the acute...
Journal Articles
Narayanaswamy Venketasubramanian, Sherry H. Young, San San Tay, Thirugnanam Umapathi, Annabelle Y. Lao, Herminigildo H. Gan, Alejandro C. Baroque II, Jose C. Navarro, Hui Meng Chang, Joel M. Advincula, Sombat Muengtaweepongsa, Bernard P.L. Chan, Carlos L. Chua, Nirmala Wijekoon, H. Asita de Silva, John Harold B. Hiyadan, Nijasri C. Suwanwela, K.S. Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Chun Fan Lee, Christopher L.H. Chen, for the CHIMES-E Study Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2015) 39 (5-6): 309–318.
Published Online: 22 April 2015
...; John Harold B. Hiyadan; Nijasri C. Suwanwela; K.S. Lawrence Wong; Niphon Poungvarin; Gaik Bee Eow; Chun Fan Lee; Christopher L.H. Chen; for the CHIMES-E Study Investigators Background: The CHInese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) study was an international randomized double-blind...
Journal Articles
N. Venketasubramanian, Sherry Young, San San Tay, Hui Meng Chang, T. Umapathi, Bernard Chan, Asita de Silva, Lawrence Wong, Jose Navarro, Yu-Dong Zhao, Say Beng Tan, Christopher Chen
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2013) 35 (Suppl. 1): 18–22.
Published Online: 14 March 2013
... that reduce death and disability after stroke. The ongoing international, multicenter, randomized, placebo-controlled, double-blind CHIMES trial is currently testing the hypothesis that a 3-month course of the traditional Chinese medicine MLC601 (NeuroAiD) is superior to placebo in reducing neurological...
Journal Articles
C. Heurteaux, C. Widmann, H. Moha ou Maati, H. Quintard, C. Gandin, M. Borsotto, J. Veyssiere, B. Onteniente, M. Lazdunski
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2013) 35 (Suppl. 1): 1–7.
Published Online: 14 March 2013
...C. Heurteaux; C. Widmann; H. Moha ou Maati; H. Quintard; C. Gandin; M. Borsotto; J. Veyssiere; B. Onteniente; M. Lazdunski Background: Treatments for stroke and other brain injuries are limited. NeuroAiD has been shown to be beneficial in clinical studies. We reviewed the pharmacological effects...
Journal Articles
Christopher L.H. Chen, Kamran Ikram, Qiu Anqi, Wong Tien Yin, Annabel Chen, Narayanaswamy Venketasubramanian, for the NEURITE Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2013) 35 (Suppl. 1): 23–29.
Published Online: 14 March 2013
... of evidence-based treatment options. NeuroAiD is a traditional Chinese medicine that has been shown to induce neuroplasticity, promote cell proliferation and stimulate the development of dense axonal and dendritic networks in animal stroke models. NeuroAiD may improve cerebral blood flow and functional...
Journal Articles
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2013) 35 (Suppl. 1): 30–37.
Published Online: 14 March 2013
... of infarct, suggesting that Aβ may mediate at least some of the secondary neurotoxicity observed in stroke patients. Methods: To investigate the effects of MLC601 (NeuroAiD ® ) on regulation of APP processing, the human neuroblastoma cell line SH-SY5Y was used for all experiments. Stocks of MLC601 were...
Journal Articles
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2013) 35 (Suppl. 1): 8–17.
Published Online: 14 March 2013
... TCMs have also been shown to dilate blood vessels, suppress platelet aggregation, protect against ischemic reperfusion injury and enhance the tolerance of ischemic tissue to hypoxia [ 4 ]. MLC601 (NeuroAiD®; Moleac Pte. Ltd., Singapore) is a TCM derivative and combines extracts from 9 plants (radix...
Journal Articles
Keng He Kong, Seng Kwee Wee, Chwee Yin Ng, Karen Chua, Kay Fei Chan, N. Venketasubramanian, Christopher Chen
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2009) 28 (5): 514–521.
Published Online: 09 October 2009
...Keng He Kong; Seng Kwee Wee; Chwee Yin Ng; Karen Chua; Kay Fei Chan; N. Venketasubramanian; Christopher Chen Background and Objective: Previous clinical studies have shown that Neuroaid (MLC 601) may be beneficial in post-stroke rehabilitation. Our aim was to investigate the efficacy of Neuroaid...