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1-9 of 9
Keywords: MLC601
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Journal Articles
Subject Area:
Cardiovascular System
,
Karger e-Journal Backfile Collection 2023
,
Neurology and Neuroscience
Christopher Li Hsian Chen, Yogesh Pokharkar, Narayanaswamy Venketasubramanian, for the CHIMES and CHIMES-E Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2023) 52 (2): 160–165.
Published Online: 02 May 2023
..., randomised to receive either a combination of various herbal and non-herbal components (MLC601) or placebo, administered within 72 h after an acute ischaemic stroke of intermediate severity (defined by baseline NIH Stroke Scale [b-NIHSS] score of 8–14). Associations between b-NIHSS-LMS and favourable outcome...
Journal Articles
Narayanaswamy Venketasubramanian, Rajesh B. Moorakonda, Qingshu Lu, Christopher L.H. Chen, On behalf of the CHIMES Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2020) 49 (2): 192–199.
Published Online: 03 March 2020
... on Stroke recovery (CHIMES) study safety database comparing the frequency of SAEs and their clinical impacts among subjects having received MLC601 or placebo during the first 3 months post-stroke. Methods: Analyses were performed by using the safety database of the multicentre, randomised, double-blind...
Journal Articles
Nijasri C. Suwanwela, Christopher L.H. Chen, Chun Fan Lee, Sherry H. Young, San San Tay, Thirugnanam Umapathi, Annabelle Y. Lao, Herminigildo H. Gan, Alejandro C. Baroque II, Jose C. Navarro, Hui Meng Chang, Joel M. Advincula, Sombat Muengtaweepongsa, Bernard P.L. Chan, Carlos L. Chua, Nirmala Wijekoon, H. Asita de Silva, John Harold B. Hiyadan, Ka Sing Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Narayanaswamy Venketasubramanian, CHIMES-E Study Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2018) 46 (1-2): 82–88.
Published Online: 05 September 2018
... Wijekoon; H. Asita de Silva; John Harold B. Hiyadan; Ka Sing Lawrence Wong; Niphon Poungvarin; Gaik Bee Eow; Narayanaswamy Venketasubramanian; CHIMES-E Study Investigators Background and Purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim...
Journal Articles
Narayanaswamy Venketasubramanian, Chun Fan Lee, Sherry H. Young, San San Tay, Thirugnanam Umapathi, Annabelle Y. Lao, Herminigildo H. Gan, Alejandro C. Baroque II, Jose C. Navarro, Hui Meng Chang, Joel M. Advincula, Sombat Muengtaweepongsa, Bernard P.L. Chan, Carlos L. Chua, Nirmala Wijekoon, H. Asita de Silva, John Harold B. Hiyadan, Nijasri C. Suwanwela, K.S. Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Christopher L.H. Chen, for the CHIMES-E Study Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2017) 43 (1-2): 36–42.
Published Online: 15 November 2016
... trials with long-term outcome data. We aimed to evaluate the recovery pattern and the influence of prognostic factors on treatment effect of MLC601 over 2 years. Methods: The CHIMES-E study evaluated the 2 years outcome of subjects aged ≥18 years with acute ischemic stroke, National Institutes of Health...
Journal Articles
Narayanaswamy Venketasubramanian, Sherry H. Young, San San Tay, Thirugnanam Umapathi, Annabelle Y. Lao, Herminigildo H. Gan, Alejandro C. Baroque II, Jose C. Navarro, Hui Meng Chang, Joel M. Advincula, Sombat Muengtaweepongsa, Bernard P.L. Chan, Carlos L. Chua, Nirmala Wijekoon, H. Asita de Silva, John Harold B. Hiyadan, Nijasri C. Suwanwela, K.S. Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Chun Fan Lee, Christopher L.H. Chen, for the CHIMES-E Study Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2015) 39 (5-6): 309–318.
Published Online: 22 April 2015
... placebo-controlled trial of MLC601 (NeuroAiD) in subjects with cerebral infarction of intermediate severity within 72 h. CHIMES-E (Extension) aimed at evaluating the effects of the initial 3-month treatment with MLC601 on long-term outcome for up to 2 years. Methods: All subjects randomized in CHIMES were...
Journal Articles
C. Heurteaux, C. Widmann, H. Moha ou Maati, H. Quintard, C. Gandin, M. Borsotto, J. Veyssiere, B. Onteniente, M. Lazdunski
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2013) 35 (Suppl. 1): 1–7.
Published Online: 14 March 2013
... and in cortical cell cultures. These properties would be important for developing a treatment strategy in reducing the long-term disability of stroke, cardiac arrest and other brain injuries. Consistent with observations of MLC601 efficacy in humans, pharmacological data obtained in rodents have established...
Journal Articles
Christopher L.H. Chen, Kamran Ikram, Qiu Anqi, Wong Tien Yin, Annabel Chen, Narayanaswamy Venketasubramanian, for the NEURITE Investigators
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2013) 35 (Suppl. 1): 23–29.
Published Online: 14 March 2013
... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Stroke Cognitive impairment Neuroplasticity Neuroprotection Neurogenesis MLC601 MLC901 NeuroAiD Dementia arising from cerebrovascular disease (CVD...
Journal Articles
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2013) 35 (Suppl. 1): 30–37.
Published Online: 14 March 2013
... of infarct, suggesting that Aβ may mediate at least some of the secondary neurotoxicity observed in stroke patients. Methods: To investigate the effects of MLC601 (NeuroAiD ® ) on regulation of APP processing, the human neuroblastoma cell line SH-SY5Y was used for all experiments. Stocks of MLC601 were...
Journal Articles
Journal:
Cerebrovascular Diseases
Cerebrovasc Dis (2013) 35 (Suppl. 1): 8–17.
Published Online: 14 March 2013
...Fahad Javaid Siddiqui; Narayanaswamy Venketasubramanian; Edwin Shih-Yen Chan; Christopher Chen Background: Subsequent to a pooled analysis of 2 trials, several more studies have been published assessing the benefit of MLC601 in stroke patients. Hence, it is timely to conduct an updated meta...