... with knowledge in the field dating back to 1991. Given the breadth of the subject, we have chosen to focus on ischemic forms of cSVD and will voluntarily leave aside the hemorrhagic markers of arteriolosclerosis and cerebral amyloid angiopathy. Cerebral small-vessel disease Lacunes Lacunar stroke...

...Shuai Jiang; Simiao Wu; Shuting Zhang; Bo Wu Lacunar stroke (LS) accounts for about one-quarter of all acute ischemic strokes, represents an important marker of cerebral small vessel disease (CSVD), and has prognostic significance in terms of recurrent vascular events and vascular cognitive...

...Abraham Kwan; Jingkai Wei; N. Maritza Dowling; Melinda C. Power; Zurab Nadareishvili; SPS3 Study Group Introduction: Patients with poststroke cognitive impairment appear to be at higher risk of recurrent stroke and death. However, whether cognitive impairment after lacunar stroke is associated...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ischemic stroke Lacunar stroke Cerebral small vessel disease Prognosis MRI...

... matter hyperintensities we hypothesised that small vessel (lacunar) stroke would be more strongly associated with renal failure than cortical stroke. Therefore, we performed a systematic review and meta-analysis to establish first if lacunar stroke was associated with the renal function, and second...

.... Results: The incidence of hemorrhagic stroke was significantly lower in the cilostazol group than in the aspirin group among patients with prior lacunar stroke (0.36 vs. 1.20% in person-year, HR 0.35, 95% CI 0.18-0.70, p < 0.01), but not among those with prior atherothrombotic stroke (0.31 vs. 0.59...

... to about 40% of dementias. Various processes have been implicated, including microatheroma, endothelial dysfunction and inflammation. A previous review investigated endothelial dysfunction in lacunar stroke versus mostly non-stroke controls while another looked at markers of inflammation and endothelial...

... to flowing red blood cells at its luminal side, called the perfused boundary region (PBR). Glycocalyx damage results in increased PBR, which can be measured in the sublingual microvasculature. We tested whether PBR is increased in patients with cerebral small vessel disease, i.e. lacunar stroke patients...

...Carole L. White; Leslie A. McClure; Patricia M. Wallace; Janet Braimah; Alice Liskay; Ana Roldan; Oscar R. Benavente; for the SPS3 Investigators Background: Little is known about post-stroke depression in patients with lacunar stroke due to cerebral small vessel disease. Our objectives were...

.... This break in the ‘stroke wave’ is particularly striking after atherosclerotic and lacunar strokes. Cardioembolic stroke Atherosclerotic stroke Ischemic stroke Lacunar stroke Previous event Recurrence The natural history of ischemic stroke is still incompletely understood. Although several...

...Joanna M. Wardlaw; Fergus N. Doubal; Elizabeth Eadie; Francesca Chappell; Kirsten Shuler; Vera Cvoro Atheromatous middle cerebral artery (MCA) stenosis could cause lacunar stroke by occluding lenticulostriate artery origins, but atheroma is common, and previous studies lacked suitable controls. We...

...). Similarly, MetS related more to CS compared to LS with WML (OR 2.56; 95% CI 1.03–6.37). Conclusion: MetS relates more strongly to LS without WML and to CS, than to LS with WML. Our results suggest a different underlying mechanism between LS without WML and CS, and lacunar stroke with WML. 17 08...

...Iris L.H. Knottnerus; Hugo Ten Cate; Jan Lodder; Fons Kessels; Robert J. van Oostenbrugge Background: Endothelial dysfunction is thought to play an important role in the pathogenesis and progression of cerebral small-vessel disease in lacunar stroke patients. Methods: We systematically searched...

..., Russo T, Cerone D, Carolei A: A population-based study of the incidence and prognosis of lacunar stroke. Neurology 2006;66:1335–1338. 16. Fisher CM: The arterial lesions underlying lacunes. Acta Neuropathol (Berl) 1969;12:1–15. 17. Lammie GA, Brannan F, Slattery J, Warlow CP: Nonhypertensive...

...A. Chamorro; M. Revilla; V. Obach; M. Vargas; A.M. Planas Background and Purpose: The CC genotype of the –174 G/C interleukin (IL)-6 polymorphism has been associated with lacunar stroke. However, it remains unsettled whether this polymorphism is also associated with other ischemic stroke phenotypes...

...P.H. Lalive; I. Mayor; R. Sztajzel Lacunar strokes (LS) are often preceded by repetitive transitory ischaemic attacks (TIAs) known as ‘capsular warning syndrome’. The treatment of these symptoms remains controversial. Anticoagulants are often used in this situation, most of the time, however...

...S. Kazui; C.R. Levi; E.F. Jones; L. Quang; P. Calafiore; G.A. Donnan Objective: Since little is known concerning factors which may influence long-term prognosis of patients presenting with lacunar stroke, we conducted a longitudinal study of this stroke subtype. Variables likely to affect outcome...

...: Intracerebral haemorrhage. Stroke 1991;22:684–691. 10. Luijckx GJ, Boiten J, Lodder J: Is the vasculopathy underlying symptomatic lacunar stroke part of a generalised small vessel disease? (abstract). Cerebrovasc Dis 1995;5:232. 11. Janssens E, Mounier-Veheir F, Hamon M, Leys D: Small subcortical...

...Haruko Yamamoto; Julien Bogousslavsky 17 1 1997 Recurrent stroke Ischemic stroke Brain hemorrhage Cerebral embolism Lacunar stroke 1997 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. TIA Clustering TIA Stroke prognosis Lacunar stroke Anticoagulants Small vessel disease Original Paper Cerebrovasc Dis 1993:3:213-220 Manuela Crespo Teresa P. Meló...