...Jelis Boiten; Peter M. Rothwell; Jim Slattery; Charles P. Warlow We compared the degree of carotid stenosis, risk factor profile, and effect of carotid surgery on incidence and type of recurrent stroke in lacunar infarct and non-lacunar infarct patients from the European Carotid Surgery Trial...

...Margareta Samuelsson; Dan Lindell; Bo Norrving We report presumed mechanisms of recurrent stroke in a prospective study on patients with lacunar infarction. Eighty-one patients with clinical and magnetic resonance imaging (MRI) findings compatible with lacunar infarction were followed for a median...

... high-density lipoprotein level. Lacunar infarcts (LS) account for 25% of all ischemic strokes and are small, deeply located brain infarcts. Two different subtypes exist, which are distinguished by the presence of concomitant white matter lesions (WML) on brain imaging. We determined the prevalence...

... lacunar infarcts in a nested sample from a subset of the Atherosclerosis Risk in Communities (ARIC) cohort. Methods: 196 cases without clinical strokes had lacunar infarcts by MRI, and 214 controls without radiographic infarcts were frequency-matched by age group and sex. Logistic regression models were...

...Jin-Seok Kim; Hak-Seung Lee; Hyun-Young Park; Soo-Seong Kim; Hyun-Goo Kang; Nam-Ho Kim; Jong-Seong Park; Yosik Kim Background: There are conflicting evidences on endothelial function in lacunar infarction. This may be attributed to the effects of risk factors on the vascular smooth muscle. To test...

... hoc analysis of the first European Cooperative Acute Stroke Study showed that the identification of lacunar infarction based on clinical grounds and/or CT findings was not possible. Less than one third of the lacunar strokes was diagnosed as lacunar infarction [ 20 ]. In our study, about 50...

... with the nondiabetics in the placebo group (9.4 vs. 4.7%/year, p = 0.01). Furthermore, our study showed that the relative risk reduction (RRR) for recurrence of infarction was 41.7% with cilostazol. This treatment provided a significant benefit in patients with lacunar infarction (RRR 43.4%, p = 0.04), with diabetes...

..., between patients with lacunar infarction with and without mild cognitive impairment of the vascular type (MCI-V). Methods: A total of 40 patients with lacunar infarction were studied within 1 month after stroke. Results: MCI-V was found in 22 patients, who in comparison with patients without cognitive...

...K. Gormley; S. Bevan; H.S. Markus Background: Genetic variation in the renin-angiotensin system (RAS) has been implicated in stroke, particularly the small vessel disease (SVD) subtype. Furthermore, there may be two distinct subtypes of cerebral SVD, isolated lacunar infarction (ILI) and ischaemic...

...Miguel Blanco; Mar Castellanos; Manuel Rodríguez-Yáñez; Tomás Sobrino; Rogelio Leira; José Vivancos; Ignacio Lizasoain; Joaquín Serena; Antonio Dávalos; José Castillo Lacunar infarction has long been considered to be associated with good prognosis, however a significant percentage of these patients...

... to in the content or advertisements. Stroke Cerebral infarction Atherosclerosis Carotid stenosis Lacunar infarction Hypercholesterolaemia Lipid-lowering therapy using statins prevents ischaemic stroke in patients with myocardial infarction as well as the progression of carotid atherosclerosis[ 1...

... dysfunction of cerebral arteries is present in patients with lacunar cerebral infarctions. Methods: Cerebrovascular reactivity to L- arginine, which reveals the function of the cerebral endothelium, was investigated in patients with lacunar infarctions (20 patients, 11 male and 9 female, aged 60.9 ± 7.3 years...

... are fundamentally similar in the East and West, but the recommended doses of antiplatelets, especially aspirin and ticlopidine, are smaller in Japan. Furthermore, Japanese guidelines only recommend the use of antiplatelets (particularly cilostazol) for patients with lacunar infarction with evidence. Figure 1...

...Peter Appelros; Margareta Samuelsson; Dan Lindell Background: There are few long-term follow-up studies of patients with lacunar infarcts (LIs). The purpose of this 5-year follow-up study was to assess functional and cognitive outcome in relation to MRI findings. Methods: 81 patients with a first...

...Jun-hui Zhang; Katsuhiko Kohara; Yasumasa Yamamoto; Jun Nakura; Yasuharu Tabara; Mutsuo Fujisawa; Ryosuke Katagi; Tetsuro Miki Objective: Lacunar infarction is a unique stroke entity with characteristic symptoms. However, it is often silent clinically. The possible genetic predisposition...

...Gert Staaf; Bo Geijer; Arne Lindgren; Bo Norrving Background and Purpose: The ‘capsular warning syndrome’ (CWS) of recurrent stereotyped episodes of motor or sensory dysfunction is clinically well recognized, and is associated with a high risk of imminent lacunar infarction with permanent deficits...

... infarction Lacunar infarction Cardioembolic stroke Thrombosis Homocyst(e)ine is a sulfur-containing amino acid, an intermediate product, produced by the demethylation of methionine [ 1, 2 ]. Elevated concentrations of blood total homocyst(e)ine (tHcy) are observed in subjects with metabolic...

... of consecutive treated hypertensive patients: (1) 11 with BD (mean age 71.3 ± 5.2 years); (2) 16 with lacunar infarction (mean age 65.2 ± 8.3 years) without cognitive impairment. An averaged baseline office BP was obtained for 3 consecutive weeks. Ambulatory BP monitoring was then carried out to obtain...

...Stefano Spolveri; Maria Cristina Baruffi; Carlo Cappelletti; Francesco Semerano; Stefania Rossi; Giovanni Pracucci; Domenico Inzitari Background: The pathogenesis of lacunar infarcts is still incompletely established. Data from the literature suggest that vascular risk factors differ among patients...

... Slattery Charles P. Warlow for the European Carotid Surgery Trialists Collaborative Group Department of Clinical Ncuroscienccs, Western General Hospital. Crewe Road, Edinburgh, UK Frequency and Degree of Carotid Stenosis in Small Centrum Ovale Infarcts as Compared to Lacunar Infarcts Key Words Lacunar...