...David G. Sherman Both anticoagulants and antiplatelet agents have been advocated, used and studied for the treatment of acute ischemic stroke. Randomized trials of unfractionated heparin, low-molecular-weight heparin and heparinoids have failed to show an overall benefit to these agents largely...

... K antagonists Atrial fibrillation Ximelagatran Warfarin Heparin Anticoagulants Ischemic stroke Anticoagulant therapy has been used for several decades to prevent or to treat arterial and venous thrombosis. The main function of anticoagulants is to prevent the production of thrombin...

.... Application of low molecular weight heparins (LMWH) has been proven to be beneficial for the prevention of VTE in ischemic stroke patients. However, there is no consensus whether and how to administer LMWH for prevention of thrombotic complications after acute spontaneous intracerebral hemorrhage (sICH...

...Hiroyuki Kawano; Kazunori Toyoda; Shigeki Miyata; Haruko Yamamoto; Akira Okamoto; Isami Kakutani; Jeanine M. Walenga; Hiroaki Naritomi; Kazuo Minematsu Background: Despite the lack of supporting evidence, unfractionated heparin (UFH) is frequently given to acute ischemic stroke patients. This study...

.... This observational evaluation was restricted to ischaemic stroke or TIA patients with AF who were started on Phenprocoumon treatment during in-hospital stay. Antithrombotic co-medication was dichotomized in heparin bridging (weight or partial thromboplastin time-adjusted heparin) or conventional treatment...

...Jens P. Dreier; Frank Lürtzing; Melanie Kappmeier; Georg Bohner; Randolf Klingebiel; Stefanie Leistner; Karl M. Einhäupl; Eva Schielke; José M. Valdueza Internal carotid artery dissection (ICAD) is a frequent etiology of stroke in the young. Immediate anticoagulation with unfractionated heparin...

... but modest benefit by reducing recurrent ischemic stroke and death given within 48 h of stroke onset. The use of anticoagulants including heparin, low molecular weight heparin, and heparinoids has not been supported by results of randomized clinical trials. Any reductions in ischemic stroke recurrence were...

...S. Mehraein; K. Schmidtke; A. Villringer; J.M. Valdueza; F. Masuhr We performed a retrospective analysis of 79 patients with cerebral sinus venous thrombosis, who were treated with a fixed regimen of dose-adjusted intravenous heparin, to determine predictors of a fatal course. The parameters...

... haemorrhage given heparin compared with control (3 trials, 819 patients, subcutaneous heparin) was 0.96 (95% CI 0.38–2.40), and for recurrent intracranial haemorrhage it was 2.00 (95% CI 0.86–4.70). There were no reliable data on the effects of antithrombotic agents on functional outcome. These scant data do...

... beings and may be useful in the treatment of ischemic stroke. In the present study, we compared the therapeutic effect of arginine esterase with that of heparin. Subjects and Methods: We studied 50 consecutive patients with acute ischemic stroke who were admitted to the Asan Medical Center. We randomly...

...M. Grond; J. Rudolf; M. Neveling; C. Stenzel; W.-D. Heiss The efficacy of rt-PA treatment within 3 h in patients with acute ischemic stroke was recently demonstrated in two large, double-blind, randomized trials. The role of postthrombolytic heparin therapy in stroke still remains unclear...

... deficits. Intracranial hemorrhage was noted on initial CT in 3 patients. One had hemorrhagic transformation of a bland cerebral infarction without use of anticoagulants, as did 1 after receiving only 1,600 IU of intravenous heparin. Of the 11 patients who had a good outcome, 5 received full-dose...