... cortex of rodents in the context of stroke recovery studies. In order to apply this model correctly, it is essential to understand the time course of regional flow changes and of the development of penumbra and infarction. Methods: Multitracer micro-PET of ET1 focal ischemia in rats was performed using...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Thrombin Embolic stroke Focal ischemia...

... enzymes disrupt protein and nucleic acid assemblies. Enhanced poly(ADP-ribose)polymerase-1 (PARP-1) and poly(ADP-ribosyl)ation after focal ischemia promote cell death by NAD + and ATP depletion, whereas PARP gene disruption and drug-dependent PARP inhibition generate resistance to cerebral ischemia [ 21...

...Wolf-Dieter Heiss; Rudolf Graf; Klaus Wienhard Repeat studies in animal models of acute focal ischemia can be compared to incidental studies in the course of ischemic stroke in order to shed light on the development of changes causing ischemic infarcts or recovery of critically perfused tissue...

... Shunya Takizawa, Antoine M. Hakim McConnell Brain Imaging Centre, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Que., Canada Key Words. Ischemic models Cerebral infarction Cerebral blood flow Focal ischemia Global ischemia Abstract...