The goal of the case-control study was to determine the frequency of ischemic stroke likely to be caused by inherent disorders of coagulation. One hundred and twelve consecutive patients with atherothrombotic stroke, transitory ischemic attack, or transient monocular blindness and 60 control patients with non-vascular diseases (age range: 23–70 years) were screened for abnormalities of fibrinogen, von Willebrand factor (vWf:Ag), antithrombin III, protein C, protein S, plasminogen and α2-plasmin inhibitor. Repeated assays in the acute and chronic stage suggested that abnormalities of fibrinogen, vWf:Ag, plasminogen, and α2-plasmin inhibitor were the response to thrombosis rather than being the cause of stroke. A deficiency in one of the natural anticoagulants (antithrombin III, protein C, total protein S) occurred in 6.2% (7/112). A persistent deficiency, likely preexistent, was found in only 1 man with a protein C level of 51% (0.8%). It is concluded that the coagulation disorders, which were included in the present study, are exceptional causes of stroke.

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