Background: The prevalence of fibromuscular dysplasia (FMD) in patients with cervical artery dissection (CAD) is unknown. Our objectives were to assess the risk of CAD recurring as a stroke or a transient ischemic attack and the association of these events with FMD. Methods: We prospectively included and followed 103 consecutive patients who had been admitted for a CAD. The median follow-up was 4 years (range 4 months to 10 years). The main criteria for inclusion were a mural hematoma demonstrated by cervical magnetic resonance imaging and/or signs suggesting CAD on 2 other investigations. FMD was diagnosed on the so-called string of beads pattern by digital subtraction angiography. Results: Five patients had CAD recurrence (60% occurred late). Four of these 5 patients had FMD. In 4 patients, CAD recurrence involved another cervical artery. Conclusion: The rate of symptomatic CAD recurrence was 1% per year and was often related to FMD.

1.
Schievink WI, Mokri B, O’Fallon WM: Recurrent spontaneous cervical artery dissection. N Engl J Med 1994;330:393–397.
2.
Bassetti C, Carruzo A, Sturzenegger M, Tuncdogan E: Recurrence of cervical artery dissection: a prospective study of 81 patients. Stroke 1996;27:1804–1807.
3.
Osborn AG, Anderson RE: Angiographic spectrum of cervical and intracranial fibro-muscular dysplasia. Stroke 1977;5:617–626.
4.
Wade DT: Rankin scale; in Wade DT (ed): Measurement in Neurological Rehabilitation. Oxford, Oxford University Press, 1992, pp 238–239.
5.
Konrad C, Muller GA, Langer C, Kulhenbaumer G, Berger K, Nabavi DG, Dziewas R, Stogbauer F, Ringelstein EB, Junker R: Plasma homocysteine MTHFR C6777TCBS 844ins68 bp and MTHFD1 G1958A polymorphisms in spontaneous cervical artery dissections J Neurol 2004;251:1242–1248.
6.
Touze E, Gauvrit JY, Moulin T, Meder JF, Bracard S, Mas JL: Risk of stroke and recurrent dissection after a cervical artery dissection. Neurology 2003;61:1347–1351.
7.
Dziewas R, Konrad C, Drager B, Evers S, Besselmann M, Ludemann P, Kuhlenbaumer G, Stogbauer F, Ringelstein EB: Cervical artery dissection – clinical features, risk factors, therapy and outcome in 126 patients. J Neurol 2003;250:1179–1184.
8.
Leys D, Moulin Th, Stojkovic T, Begey S, Chavot D; Donald investigators: Follow-up of patients with history of cervical artery dissection. Cerebrovasc Dis 1995;5:43–49.
9.
Schievink WI, Mokri B, Piepgras DG, Kuiper JD: Recurrent spontaneous arterial dissections: risk in familial versus nonfamilial disease. Stroke 1996;27:622–624.
10.
Lyrer P, Engelter S: Antithrombotic drugs for carotid artery dissection. Stroke 2004;35:613–614.
11.
Baumgartner RW, Arnolds M, Baumgartner I, Mosso M, Gonner F, Studer A, Schroth G, Schuknecht B, Sturzenegger M: Carotid dissection with and without ischemic events: local symptoms and cerebral findings. Neurology 2001;57:827–832.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.