Background: Genetic and environmental factors may be of importance for stroke risk. We assessed the prevalence of stroke and vascular risk factors among first-degree relatives and spouses of stroke patients and control subjects. Methods: As a part of the Lund Stroke Register study, we asked 925 consecutive patients with first-ever stroke and 286 control subjects to complete a questionnaire about all their first-degree relatives and spouses. The questionnaires addressed whether these relatives had been affected by stroke or TIA, hypertension, heart disease, diabetes mellitus, and if they were smokers. Results: A total of 606 patients and 261 control subjects returned the questionnaire, providing information on 4,972 first-degree relatives and 738 spouses. The prevalence of stroke or TIA was 12.3% among first-degree relatives of patients and 7.5% among first-degree relatives of control subjects (OR 1.74, 95% CI 1.36–2.22). Corresponding results for hypertension were 21.0 and 16.7% (OR 1.33, 95% CI 1.10–1.60). The prevalences of heart disease, diabetes mellitus and smoking did not differ significantly between first-degree relatives of patients and control subjects. Spouses of patients and control subjects had similar prevalences of stroke or TIA and vascular risk factors. Conclusions: The prevalences of stroke or TIA and hypertension are higher among first-degree relatives of stroke patients than among first-degree relatives of control subjects. This, and the lack of differences between spouses of patients and control subjects, indicates that an increased risk of stroke may in part be explained by heritability of hypertension.

Keywords:
First-degree relatives, Stroke, Spouses, Vascular risk factors, Heritability
1.
Meschia JF: Clinically translated ischemic stroke genomics. Stroke 2004;35 (suppl 1): 2735–2739.
2.
Flossmann E, Schulz UGR, Rothwell PM: Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke. Stroke 2004;35:212–227.
3.
Tournier-Lasserve E, Iba-Zizen MT, Romero N, Bousser MG: Autosomal dominant syndrome with strokelike episodes and leukoencephalopathy. Stroke 1991;22:1297–1302.
4.
Jerrard-Dunne P, Cloud G, Hassan A, Markus HS: Evaluating the genetic component of ischemic stroke subtypes: a family history study. Stroke 2003;34:1364–1369.
5.
Gretarsdottir S, Thorleifsson G, Reynisdottir ST, Manolescu A, Jonsdottir S, Jonsdottir T, Gudmundsdottir T, Bjarnadottir SM, Einarsson OB, Gudjonsdottir HM, Hawkins M, Gudmundsson G, Gudmundsdottir H, Andrason H, Gudmundsdottir AS, Sigurdardottir M, Chou TT, Nahmias J, Goss S, Sveinbjörnsdottir S, Valdimarsson EM, Jakobsson F, Agnarsson U, Gudnason V, Thorgeirsson G, Fingerle J, Gurney M, Gudbjartsson D, Frigge ML, Kong A, Stefansson K, Gulcher JR: The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat Genet 2003;35:131–138.
6.
Helgadottir A, Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir H, Thorsteinsdottir U, Samani NJ, Gudmundsson G, Grant SFA, Thorgeirsson G, Sveinbjörnsdottir S, Valdimarsson EM, Matthiasson SE, Johannsson H, Gudmundsdottir O, Gurney ME, Sainz J, Thorhallsdottir M, Andresdottir M, Frigge ML, Topol EJ, Kong A, Gudnason V, Hakonarson H, Gulcher JR, Stefansson K: The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 2004;36:233–239.
7.
Welin L, Svärdsudd K, Wilhelmsen L, Larsson B, Tibblin G: Analysis of risk factors for stroke in a cohort of men born in 1913. N Engl J Med 1987;317:521–526.
8.
Tentschert S, Greisenegger S, Wimmer R, Lang W, Lalouschek W: Association of parental history of stroke with clinical parameters in patients with ischemic stroke or transient ischemic attack. Stroke 2003;34:2114–2119.
9.
Hassan A, Sham PC, Markus HS: Planning genetic studies in human stroke: sample size estimates based on family history data. Neurology 2002;58:1483–1488.
10.
Rothman KJ, Greenland S: Modern Epidemiology, ed 2. Philadelphia, Lippincott-Raven Publishers, 1998.
11.
Wolf PA: Prevention of stroke. Lancet 1998;352(suppl 3):SIII15–SIII18.
12.
Warlow C, Sudlow C, Dennis M, Wardlaw J, Sandercock P: Stroke. Lancet 2003;362:1211–1224.
13.
Knudson AG Jr: Hereditary cancer, oncogenes, and antioncogenes. Cancer Res 1985;45:1437–1443.
14.
Al Mamun A, Peeters A, Barendregt J, Willekens F, Nusselder W, Bonneux L: Smoking decreases the duration of life lived with and without cardiovascular disease: a life course analysis of the Framingham Heart Study. Eur Heart J 2004;25:409–415.
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2005
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