Background/Objectives: Cerebral venous thrombosis may cause focal brain lesions or an isolated intracranial hypertension without focal signs. We investigated whether these different clinical pictures correspond to different patterns of dural sinus thrombosis. Methods: Forty-eight patients with cerebral venous thrombosis were classified in 2 groups based on the clinical and neuroradiological picture at admission: one group had clinical signs of intracranial hypertension, without focal neurological signs; the other group had focal neurological signs. The extension of thrombosis in dural sinuses was compared between the groups. Results: The amount of thrombosed sinuses was significantly different in the two groups, the involvement of the dural sinuses being greater in patients with isolated intracranial hypertension. Conclusions: The clinical picture of cerebral venous thrombosis is related to the pattern of dural sinus involvement. The presence of isolated intracranial hypertension is more frequent in patients with a more extended thrombosis of the dural sinuses.

Keywords:
Cerebral veins, Cerebral venous thrombosis, Sinus thrombosis
1.
Biousse V, Ameri A, Bousser MG: Isolated intracranial hypertension as the only sign of cerebral venous thrombosis. Neurology 1999;53:1537–1542.
2.
Leker RR, Steiner I: Cerebral venous thrombosis mimicking idiopathic intracranial hypertension. Eur J Neurol 1999;6:601–604.
3.
Cantu C, Barinagarrementeria F: Cerebral venous thrombosis associated with pregnancy and puerperium. Review of 67 cases. Stroke 1993;24:1880–1884.
4.
Bousser MG, Russel RR: Cerebral Venous Thrombosis. London, Saunders, 1997, pp 15–17.
5.
Kalbag RM: Dural sinus thrombosis. J Neurol Neurosurg Psychiatry 1967 ;30:586.
6.
Bergui M, Bradac GB, Daniele D: Brain lesions due to cerebral venous thrombosis do not correlate with sinus involvement. Neuroradiology 1999;41:419–424.
7.
Buonanno F, Moody DM, Ball MR, Laster DW: Computed cranial tomographic findings in cerebral sinovenous occlusion. J Comput Assist Tomogr 1978;2:281–290.
8.
Macchi PJ, Grossman RI, Gomori JM, Goldberg HI, Zimmerman RA, Bilaniuk LT: High field imaging of cerebral venous thrombosis. J Comput Assist Tomogr 1986;10:10–15.
9.
Isensee Ch, Reul J, Thron A: Magnetic resonance imaging of thrombosed dural sinuses. Stroke 1994;25:29–34.
10.
Tsuruda JS, Shimakawa A, Pelc NJ, Saloner D: Dural sinus occlusion: Evaluation with phase-sensitive gradient-echo MR imaging. AJNR Am J Neuroradiol 1991;12:481–488.
11.
Jacobs K, Moulin T, Bogousslavsky J, Woimant F, Dehaene I, Tatu L, Besson G, Assouline E, Casselman J: The stroke syndrome of cortical vein thrombosis. Neurology 1996;47:376–382.
12.
Brucker AB, Vollert-Rogenhofer H, Wagner M, Stieglbauer K, Felber S, Trenkler J, Deisenhammer E, Aichner F: Heparin treatment in the acute cerebral sinus thrombosis: A retrospective clinical and MR analysis in 42 cases. Cerebrovasc Dis 1998;8:331–333.
13.
de Bruijn SF, de Haan RJ, Stam J, for the Cerebral Venous Sinus Thrombosis Study Group: Clinical features and prognostic factors of cerebral venous sinus thrombosis in a prospective series of 59 patients. J Neurol Neurosurg Psychiatry 2001;70:105–108.
14.
Ferro JM, Lopes MG, Rosas MJ, Ferro MA, Fontes J: Long-term prognosis of cerebral vein and dural sinus thrombosis. Results of the VENOPORT Study. Cerebrovasc Dis 2002;13:272–278.
15.
Bianchi D, Maeder P, Bogousslavsky J, Schnyder P, Meuli RA: Diagnosis of cerebral venous thrombosis with routine magnetic resonance: An update. Eur Neurol 1998;40:179–190.
16.
Karahlios DG, Rekate HL, Kahayata MH, Apostolides PJ: Elevated intracranial venous pressure as a universal mechanism in pseudotumor cerebri of various etiologies. Neurology 1996;46:198–202.
17.
Villringer A, Mehraein S, Einhaupl KM: Pathophysiological aspects of cerebral sinus venous thrombosis (SVT). J Neuroradiol 1994;21:72–80.
18.
Fries G, Wallenfang T, Hennen J, Velthaus M, Heimann A, Schild H, Perneczky A, Kempski O: Occlusion of the pig superior sagittal sinus, bridging and cortical veins: Multistep evolution of sinus-vein thrombosis. J Neurosurg 1992;77:127–133.
19.
Rother J, Waggie K, van Bruggen N, de Crespigny AJ, Moseley ME: Experimental cerebral venous thrombosis: Evaluation using magnetic resonance imaging. J Cereb Flow Metab 1996;16:1353–1361.
20.
Gotoh M, Ohmoto T, Kuyama H: Experimental study of venous circulatory disturbance by dural sinus occlusion. Acta Neurochir 1993;124:120–126.
21.
Yoshimoto Y, Endo M, Mori T, Wakay S: Correlation between venous stump pressure and brain damage after cortical vein occlusion: An experimental study. J Neurosurg 1997;86:694–698.
22.
Lewis MB, Bousser MG: Cerebral venous thrombosis: Nothing, heparin, or local thrombolysis? Stroke 1999;30:1729.
23.
Bradac GB, Bergui M: Role of the different venous structures involved in cerebral venous thrombosis. Klin Neuroradiol 2001;11:20–24.
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2003
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