Deep hemispheric or brainstem small infarcts can lead to atypical lacunar syndromes. Unilateral internuclear ophthalmoplegia (INO) and cerebellar ataxia has not been reported previously. A 57-year-old hypertensive female presented with bilateral appendicular and left truncal cerebellar ataxia and right INO. Cranial MRI showed a right paramedian infarct of lacunar size located in the tegmentum of caudal mesencephalon. At this level the involvement of medial longitudinal fascicle (MLF) led to right INO and the lesion of brachium conjunctivum caused the bilateral cerebellar ataxia. Ipsilateral involvement of both cerebellofugal fibers, before and after decussation, was responsible for bilateral cerebellar ataxia.

1.
Fisher CM: Lacunar infarcts. A review. Cerebrovasc Dis 1991;1:311–320.
2.
Hommel M, Besson G, Le Bas JF, Gaio JM, Polak P, Borgel F, Perret J: Prospective study of lacunar infarction using magnetic resonance imaging. Stroke 1990;21:546–554.
3.
Besson G, Hommel M: Lacunar syndromes; in Pullicino PM, Caplan LR, Hommel M (eds): Cerebral Small Artery Disease. Advances in Neurology. New York, Raven Press, 1993, vol 62, pp 141–160.
4.
Randolph S, Sacco RL, Kreuger R, Odel J: Dissociated vertical nystagmus and internuclear ophthalmoplegia from a midbrain infarction. Arch Neurol 1991;38:1304–1305.
5.
Bogousslavsky J, Maeder P, Regli F, Meuli R: Pure midbrain infarction: Clinical syndromes, MRI, and etiologic patterns. Neurology 1994;44:2032–2040.
6.
Okuda B, Tachibana H, Sugita M, Maeda Y: Bilateral internuclear ophthalmoplegia, ataxia and tremor from a midbrain infarction. Stroke 1993;24:481–482.
7.
Sakakibara S, Sakato S, Shima T, Ide Y, Takamori M: Brainstem infarcts presented MLF syndrome and cerebellar ataxia. Report of three cases. Rinsho Shinkeigaku 1990;30:533–539.
8.
Kirham TH, Katsarkas A: An electrooculographic study of internuclear ophthalmoplegia. Ann Neurol 1977;2:385–392.
9.
Leigh RJ, Zee DS: Diagnosis of central disorders of ocular motility; in Leigh RJ, Zee DS (eds): The Neurology of Eye Movements. Contemporary Neurology Series. Philadelphia, Davis, 1991, vol 35, pp 378–530.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.