Stroke is one of the most frequent causes of seizures in adulthood. Subcortical infarcts have been associated with post-stroke epileptic seizures, although less frequently than cortical ischaemia. We studied 113 patients from a hospital stroke registry. The patients had subcortical non-lacunar infarcts (64 striatocapsular infarcts, 13 thalamic, 8 choroidal artery territory, 28 internal border zone and white matter medullary infarcts) and at least 1 year of follow-up. Only 4 patients (3.5%) with striatocapsular infarcts suffered an epileptic seizure. Two seizures occurred within the first 24 h, 1 within the first month and 1 within the first year of stroke onset. Emboligenic cardiac conditions were significantly more common in patients with seizures (difference 37%; 95% confidence intervals 2–72%). Subsequently to subcortical infarct, epileptic seizures are infrequent, tend to occur early after stroke and have a very low 1-year recurrence risk.

1.
Pohlmann-Eden B, Cochius J: Stroke and epilepsy: Critical review of the literature. Epidemiology and risk factors. Cerebrovasc Dis 1996;7:332–338.
2.
Pohlmann-Eden B, Cochius J: Stroke and epilepsy: Critical review of the literature. Risk factors, pathophysiology and overlap syndromes. Cerebrovasc Dis 1997;7:2–9.
3.
Olsen TS, Hogenhaven H, Thage O: Epilepsy after stroke. Neurology 1987;37:1209–1211.
4.
Gupta S, Naheedy M, Elias D, Rubino F: Postinfarction seizures. A clinical study. Stroke 1998;12:1477–1481.
5.
Daniele O, Caravaglios G: Stroke-related seizures and the role of cortical and subcortical structures. J Epilepsy 1996;9:184–188.
6.
Heutz-van Raak L: Seizures following a first cerebral infarct. Risk factors and prognosis. Thesis Rijksuniversiteit Limburg, Maastricht, 1996.
7.
Coulter D: Thalamocortical anatomy and physiology; in Engel J, Pedley T (eds): Epilepsy: A Comprehensive Textbook. Philadelphia, Lippincott-Raven, 1997, pp 341–351.
8.
Proctor M, Gale K: Basal ganglia and brainstem anatomy and physiology; in Engel J, Pedley T (eds): Epilepsy: A Comprehensive Textbook. Philadelphia, Lippincott-Raven, 1997, pp 341–351.
9.
Giroud M, Gras P: Early seizures after acute stroke: A study of 1,640 cases. Epilepsia 1994;35:959–964.
10.
Schreiner A, Pohlmann-Eden B: Epileptic seizures in subcortical vascular encephalopathy. J Neurol Sci 1995;130:171–177.
11.
Arboix A, Comes E, Massons J, Garcia L, Oliveres M: Relevance of early seizures for in-hospital mortality in acute cerebrovascular disease. Neurology 1996;47:1429–1435.
12.
Canhão P, Melo TP, Salgado AV, Oliveira V, Pinto AN, Crespo M, Ferro JM: Nausea and vomiting in acute ischemic stroke. Cerebrovasc Dis 1997;7:220–225.
13.
Salgado V, Ferro J, Gouveia-Oliveira: Long-term, prognosis of first-ever lacunar strokes. A hospital-based study. Stroke 1996;27:661–666.
14.
Paolucci S, Silvestri G, Lubich S, Pratesi L, Traballesi M, Gigli GL: Poststroke late seizures and their role in rehabilitation of inpatients. Epilepsia 1997;38:266–270.
15.
Sander J, Shorvon S: Epidemiology of the epilepsies. J Neurol Neurosurg Psychiatry 1996;61:433–443.
16.
Faught E, Peters D, Bartolucci A, Moore L, Miller PC: Seizures after primary intracranial haemorrhage. Neurology 1989;39:1089–1093.
17.
Giroud M, Dumas R: Role of associated cortical lesions in motor partial seizures and lenticulostriate infarcts. Epilepsia 1995;36:465–470.
18.
Arboix A, García-Eroles L, Massons J, Oliveres M, Comes E: Predictive factors of early seizures after acute cerebrovascular disease. Stroke 1997;28:1590–1594.
19.
Reith J, Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS: Seizures in acute stroke: Predictors and prognostic significance. The Copenhagen study. Stroke 1997;22:1585–1589.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.