...Rüdiger Klapdor; Christina Weiß; Elna Kuehnle; Fabian Kohls; Julia von Ehr; Anja Philippeit; Ursula Hille-Betz Background: Prophylactic mastectomy is an effective approach to breast cancer risk reduction in patients at high risk. Further studies using standardized measures for quality of life...

...Katja Keller; Cornelia Meisel; Nannette Grübling; Andrea Petzold; Pauline Wimberger; Karin Kast Background: Prophylactic mastectomies in carriers of mutations in BRCA1 or BRCA2 are becoming increasingly more accepted. We investigated the outcome after prophylactic mastectomy, especially regarding...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. BRCA1 BRCA2 High-risk genes Prophylactic mastectomy This information together with the personal experience...

... is elevated up to 65%, especially in case of BRCA1 mutation and young age at the first breast cancer. Since bilateral prophylactic mastectomy is associated with a risk reduction of 90–95% of developing primary or contralateral breast cancer, this option is a key point within the counseling process for patient...