...Paulina Gebhart; Yen Tan; Daniela Muhr; Christina Stein; Christian Singer Introduction: Germline pathogenic variants in the BRCA1 and BRCA2 genes lead to a highly increased lifetime risk for breast and ovarian cancer. These variants are usually inherited and reports of de novo occurrences...

... for Hereditary Breast and Ovarian Cancer (GC-HBOC), we have previously shown that women with TNBC diagnosed before the age of 50 years but without a family history of breast or ovarian cancer (sTNBC) meet this criterion. The present study investigates the PV prevalence in BRCA1, BRCA2, and nine additional cancer...

... or advertisements. Consensus Panel testing Hereditary breast cancer Hereditary ovarian cancer BRCA1 BRCA2 With the TruRisk® gene panel, the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) offers genetic diagnostics according to the latest state of science. The multigene...

...Emma R. Woodward; Elke M. van Veen; D. Gareth Evans Background: There has been huge progress over the last 30 years in identifying the familial component of breast cancer. Summary: Currently around 20% is explained by the high-risk genes BRCA1 and BRCA2 , a further 2% by other high-penetrance genes...

... usually show an early onset of the disease, as well as a positive family history of breast and/or ovarian cancer in more than one third of all cases, which suggests that TNBC is closely associated with a hereditary disease cause. In unselected TNBC cases, the prevalence of pathogenic germline BRCA1/2...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. BRCA1 BRCA2 High-risk genes Prophylactic mastectomy Rates of prophylactic bilateral mastectomy (PBM) and particularly prophylactic contralateral mastectomy...