Abstract
The Breast Committee of the Arbeitsgemeinschaft Gynäkologische Onkologie (German Gynecological Oncology Group, AGO) presents the 2022 update of the evidence-based recommendations for the diagnosis and treatment of patients with locally advanced and metastatic breast cancer.
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References
1.
Empfehlungen Gynäkologische Onkologie Kommission Mamma. 2022. Available from: www.ago-online.
2.
André
F
, Ciruelos
E
, Rubovszky
G
, Campone
M
, Loibl
S
, Rugo
HS
, . Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer
. N Engl J Med
. 2019 May
;380
:1929
–40
.3.
Fribbens
C
, O’Leary
B
, Kilburn
L
, Hrebien
S
, Garcia-Murillas
I
, Beaney
M
, . Plasma ESR1 mutations and the treatment of estrogen receptor-positive advanced breast cancer
. J Clin Oncol
. 2016 Sep
;34
:2961
–8
.4.
Hymann
DM
, Piha-Paul
SA
, Won
H
, Rodon
J
, Saura
C
, Shapiro
GI
, . HER kinase inhibition in patients with HER2- and HER3-mutant cancers
. Nature
. 2018 Feb
;554
:189
–94
.5.
Cocco
E
, Scaltriti
M
, Drilon
A
. NTRK fusion-positive cancers and TRK inhibitor therapy
. Nat Rev Clin Oncol
. 2018 Dec
;15
:731
–47
.6.
Bidard
FC
, Peeters
DJ
, Fehm
T
, Nolè
F
, Gisbert-Criado
R
, Mavroudis
D
, . Clinical validity of circulating tumor cells in patients with metastatic breast cancer. A pooled analysis of individual patient data
. Lancet Oncol
. 2014 Apr
;15
(4
):406
–14
.7.
Mosele
F
, Remon
J
, Mateo
J
, Westphalen
CB
, Barlesi
F
, Lolkema
MP
, . Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO precision medicine working group
. Ann Oncol
. 2020 Nov
;31
(3
):1491
–505
.8.
Im
SA
, Lu
YS
, Bardia
A
, Harbeck
N
, Colleoni
M
, Franke
F
, . Overall survival with Ribociclib plus endocrine therapy in breast cancer
. N Engl J Med
. 2019 Jul
;381
(4
):307
–16
.9.
Hortobagyi
GN
, Stemmer
SM
, Burris
HA
, Yap
YS
, Sonke
GS
, Hart
L
, . Overall survival with Ribociclib plus letrozole in advanced breast cancer
. N Engl J Med
. 2022 Mar
;386
(10
):942
–50
.10.
Tolaney
SM
, Wardley
AM
, Zambelli
S
, Hilton
JF
, Troso-Sandoval
TA
, Ricci
F
, . Abemaciclib plus trastuzumab with or without fulvestrant versus trastuzumab plus standard-of-care chemotherapy in women with hormone receptor-positive, HER2-positive advanced breast cancer (monarcHER): a randomised, open-label, phase 2 trial
. Lancet Oncol
. 2020 Jun
;21
(6
):763
–75
.11.
Schmid
P
, Rugo
HS
, Adams
S
, Schneeweiss
A
, Barrios
CH
, Iwata
H
, . Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial
. Lancet Oncol
. 2020 Dec
;21
:44
–59
.12.
Miles
D
, Gligorov
J
, Andre
F
, Cameron
D
, Schneeweiss
A
, Barrios
CH
, . Primary results from impassion131, a double-blind placebo-controlled randmised phase III trial of first-line paclitaxel +/− atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer
. Ann Oncol
. 2020 Aug
;31
(Suppl 4
):S1142
–215
.13.
Taylor
AM
, Chan
DLH
, Tio
M
, Patil
SM
, Traina
TA
, Robson
ME
, . PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer
. Cochrane Database Syst Rev
. 2021 Apr
;4
(4
):CD011395
.14.
Tung
NM
, Robson
ME
, Ventz
S
, Santa-Maria
CA
, Nanda
R
, Marcom
PK
, . TBCRC 048: phase II study of olaparib for metastatic breast cancer and mutations in homologous recombination-related genes
. J Clin Oncol
. 2020 Dec
;38
:4274
–82
.15.
Cortés
J
, Kim
SB
, Chung
WP
, Im
SA
, Park
YH
, Hegg
R
, . Trastuzumab deruxtecan versus trastuzumab emtansine for breast cancer
. N Engl J Med
. 2022 Mar
;386
(12
):1143
–54
.16.
Murthy
RK
, Loi
S
, Okines
A
, Paplomata
E
, Hamilton
E
, Hurvitz
SA
, . Tucatinib, trastuzumab, and capecitabine for HER2-positive metastatic breast cancer
. N Engl J Med
. 2020 Feb
;382
(7
):597
–609
.17.
Tesfamariam
Y
, Jakob
T
, Wöckel
A
, Adams
A
, Weigl
A
, Monsef
I
, . Adjuvant bisphosphonates or RANK-ligand inhibitors for patients with breast cancer and bone metastases: a systematic review and network meta-analysis
. Crit Rev Oncol Hematol
. 2019 May
;137
:1
–8
.18.
Clemons
M
, Ong
M
, Stober
C
, Ernst
S
, Booth
C
, Canil
C
, . A randomised trial of 4- versus 12-weekly administration of bone-targeted agents in patients with bone metastases from breast or castration-resistant prostate cancer
. Eur J Cancer
. 2021 Jan
;142
:132
–40
.20.
Srivastava
A
, Nogueras Gonzales
GM
, Geng
Y
, Won
AM
, Cabanillas
ME
, Naing
A
, . Prevalence of medication related osteonecrosis of the jaw in patients treated with sequential antiresorptive drugs: systematic review and meta-analysis
. Support Care Cancer
. 2021 May
;29
(5
):2305
–17
.21.
Kumar
A
, Weber
MH
, Gokaslan
Z
, Wolinsky
JP
, Schmidt
M
, Rhines
L
, . Metastatic spinal cord compression and steroid treatment a systematic review
. Clin Spine Surg
. 2017
;30
(4
):156
–63
.22.
Kuksis
M
, Gao
Y
, Tran
W
, Hoey
C
, Kiss
A
, Komorowski
AS
, . The incidence of brain metastases among patients with metastatic breast cancer: a systematic review and meta-analysis
. Neuro Oncol
. 2021 May
;23
(6
):894
–904
.23.
Le Rhun
E
, Guckenberger
M
, Smits
M
, Dummer
R
, Bachelot
T
, Sahm
F
, . EANO-ESMO clinical practice guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours
. Ann Oncol
. 2021 Mar
;32
(11
):1332
–47
.24.
Lin
N
, Borges
V
, Anders
C
, Murthy
R
, Paplomata
E
, Hamilton
E
, . Intracranial efficacy and survival with tucatinib plus trastuzumab and capecitabine for previously treated HER2-positive breast cancer with brain metastases in the HER2CLIMB trial
. J Clin Oncol
. 2020 Aug
;38
(23
):610
–2619
.25.
Fitzal
F
, Bjelic-Radisic
V
, Knauer
M
, Steger
G
, Hubalek
M
, Balic
M
, . Impact of breast surgery in primary metastasized breast cancer: outcomes of the prospective randomized phase III ABCSG-28 POSYTIVE trial
. Ann Surg
. 2019 Jun
;269
(6
):1163
–9
.26.
Khan
SA
, Zhao
F
, Solin
LJ
, Goldstein
LJ
, Cella
D
, Basik
M
, . A randomized phase III trial of systemic therapy plus early local therapy versus systemic therapy alone in women with de novo stage IV breast cancer: a trial of the ECOG-ACRIN research group (E2108)
. J Clin Oncol
. 2020
;38
(18 Suppl
.27.
Badwe
R
, Hawaldar
R
, Nair
N
, Kaushik
R
, Parmar
V
, Siddique
S
, . Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial
. Lancet
. 2015 Oct
;16
(13
):1380
–8
.28.
Soran
A
, Ozmen
V
, Ozbas
S
, Karanlik
H
, Muslumanoglu
M
, Igci
A
, . Primary surgery with systemic therapy in patients with de Novo stage IV breast cancer: 10-year follow-up; protocol MF07-01 randomized clinical trial
. J Am Coll Surg
. 2021 Dec
;233
(6
):742
–51
.29.
Bjelic-Radisic
V
, Fitzal
F
, Knauer
M
, Steger
G
, Egle
D
, Greil
R
, . Primary surgery versus no surgery in synchronous metastatic breast cancer: patient-reported quality-of-life outcomes of the prospective randomized multicenter ABCSG-28 Posytive trial
. BMC Cancer
. 2020 May
;20
(1
):392
.30.
Soran
A
, Dogan
L
, Isik
A
, Ozbas
S
, Trabulus
DC
, Demirci
U
, . The effect of primary surgery in patients with De Novo stage IV breast cancer with bone metastasis only (Protocol BOMET MF 14-01): a multi-center, prospective registry study
. Ann Surg Oncol
. 2021 Sep
;28
(9
):5048
–57
.31.
Magnoni
F
, Colleoni
M
, Mattar
D
, Corso
G
, Bagnardi
V
, Frassoni
S
, . Contralateral axillary lymph node metastases from breast carcinoma: is it time to review TNM cancer staging
. Ann Surg Oncol
. 2020 Oct
;27
(11
):4488
–99
.32.
Nash
AL
, Thomas
SM
, Plichta
JK
, Fayanju
OM
, Hwang
ES
, Greenup
RA
, . Contralateral axillary nodal metastases: stage IV disease or a manifestation of progressive locally advanced breast cancer
. Ann Surg Oncol
. 2021 Oct
;28
(10
):5544
–52
.33.
Sharma
BB
, Rai
K
, Blunt
H
, Zhao
W
, Tosteson
TD
, Brooks
GA
. Pathogenic DPYD variants and treatment-related mortality in patients receiving fluoropyrimidine chemotherapy: a systematic review and meta-analysis
. Oncologist
. 2021 Dec
;26
(12
):1008
–16
.34.
Modi
S
, Saura
C
, Yamashita
T
, Park
YH
, Kim
SB
, Tamura
K
, . Trastuzumab deruxtecan in previously treated HER2-positive breast cancer
. N Engl J Med
. 2020 Feb
;382
(7
):610
–21
.35.
Bardia
A
, Hurvitz
SA
, Tolaney
SM
, Loirat
D
, Punie
K
, Oliveira
M
, . Sacituzumab govitecan in metastatic triple-negative breast cancer
. N Engl J Med
. 2021
;384
(16
):1529
–41
.36.
Barcenas
CH
, Hurvitz
SA
, Di Palma
JA
, Bose
R
, Chien
AJ
, Iannotti
N
, . Improved tolerability of neratinib in patients with HER2-positive early-stage breast cancer: the CONTROL trial
. Ann Oncol
. 2020 Sep
;31
:1223
–30
.37.
Raschi
E
, Fusaroli
M
, Ardizzoni
A
, Poluzzi
E
, De Ponti
F
. Cyclin-dependent kinase 4/6 inhibitors and interstitial lung disease in the FDA adverse event reporting system: a pharmacovigilance assessment
. Breast Cancer Res Treat
. 2021 Feb
;186
(1
):219
–27
.38.
Hwang
JP
, Feld
JJ
, Hammond
SP
, Wang
SH
, Alston-Johnson
DE
, Cryer
DR
, . Hepatitis B virus screening and management for patients with cancer prior to therapy: ASCO provisional clinical opinion update
. J Clin Oncol
. 2020 Nov
;38
:3698
–715
.39.
Cardoso
F
, Paluch-Shimon
S
, Senkus
E
, Curigliano
G
, Aapro
MS
, André
F
, . 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)
. Ann Oncol
. 2020 Dec
;31
(12
):1623
–49
.40.
Lin
NU
, Thomssen
C
, Cardoso
F
, Cameron
D
, Cufer
T
, Fallowfield
L
, . International guidelines for management of metastatic breast cancer (MBC) from the European School of Oncology (ESO)-MBC task force: surveillance, staging, and evaluation of patients with early-stage and metastatic breast cancer
. Breast
. 2013 Jun
;22
(3
):203
–10
.41.
Ferrell
BR
, Temel
JS
, Temin
S
, Smith
TJ
. Integration of palliative care into standard oncology care: ASCO clinical practice guideline update summary
. J Oncol Pract
. 2017 Jan
;13
(2
):119
–21
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