... (CVVHD) in vitro experimental models. Experiments ran for 180 min, using 3 L of human blood, heparin anticoagulation and a machine dose of 30 mL/kg/h. Urea and fluoride were measured in the inflow, outflow and effluent lines to compare sieving coefficients (SC), saturation coefficients (SA...

... are on continuous venovenous hemofiltration (CVVH) in the presence of kidney dysfunction, the sieving coefficient of clonidine is required to estimate how much drug is removed by CVVH. In the present study, we measured the sieving coefficient of clonidine in critically ill, ventilated patients receiving CVVH...

.... Blood purification Sieving coefficient Clearance Cytokines High cut-off membrane In this in vitro simulation, HCO-CVVHDF performed with regional anticoagulation with isotonic concentrated citrate solution does not increase the albumin transmembrane removal compared to standard CVVHD...

... a certain amount of albumin in order to remove much larger solutes than β 2 -microglobulin and obtain better clinical outcomes. Previously, ultrafiltration experiments were performed in vitro using aqueous albumin solution and commercial diafilters. The results showed a high sieving coefficient for albumin...

... high cut-off membrane (CUREFLO™; Asahi Kasei Kuraray Medical Co., Ltd., Tokyo, Japan) has been evaluated in this study to assess IL-6 and advanced oxidation protein product removal in critically ill patients undergoing continuous renal replacement therapy. Unit performance, sieving coefficients...

... 3.86%, amino acids 2.70, and glycerol 2.50%. Diffusive mass transport coefficient (K Bd ) and sieving coefficient (S) were assessed for urea, creati-nine, glucose, glycerol, potassium, sodium, and total protein using the Babb-Randerson-Farrell model. The estimated K Bd values for small solutes were...

...Leah J. Langsdorf; Andrew L. Zydney The effects of blood-membrane interactions on hydraulic permeability, sieving coefficients, and diffusive permeabilities of Cuprophan and AN69 polyacrylonitrile hemodialysis membranes were studied using polydisperse dextrans (MW 5,000-20,000). Blood contact had...

... of 0, 1 and 3 1/h. By using a mathematical model of CAVHD, we analysed the data in terms of sieving coefficients and diffusive mass transfer coefficients. These parameters proved to be related to drug protein binding and molecular weight. The parameter values may be used to calculate the expected drug...

... in a continuous filtration flow of 70 m1/min which is quantitatively replaced by an albumin (30 g/l) substitution fluid. Thus, a 4,000-m1 plasma exchange can be performed within 1 h and an equal or even better sieving coefficient for IgG (S = 0.81) is achieved compared with the continuous technique using two...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. AN69 Polysulfone Piperacillin Tazobactam Sieving coefficient Saturation coefficient Continuous venovenous hemofiltration Continuous...