... to multiple organ dysfunction and high mortality rates. Continuous renal replacement therapy (CRRT) and extracorporeal blood purification therapies have emerged as vital adjuncts to manage fluid overload and modulate immune responses in septic shock. This study evaluates the impact of daily fluid balance...

.... Recently, new therapeutic approaches, such as immune modulation and blood purification, have been tried to improve outcomes in patients with septic shock. Methods: This study is a prospective observational study composed of children with septic shock and the PELOD-2 score ≥10 or the PRISM-3 score ≥15. All...

... years and weighing 11–60 kg were admitted with vasoplegic shock and acute kidney injury. They received thirteen sessions of oXiris© therapy for septic shock ( N = 7) and liver failure ( N = 6). Eight patients did not improve their condition during the session, and five ultimately died (37.5% survival...

...Sevda Onuk; Aynur Karayol Akin; Ali Sari; Kursat Gundogan; Gulden Baskol; Kudret Dogru; Murat Sungur Introduction: Blood purification therapy is a method used to enable cytokine removal and to improve disturbed immune homeostasis in patients with sepsis or septic shock. This study aimed to evaluate...

... severe septic shock with acute kidney injury (AKI) that requires renal replacement therapy (RRT) is unclear. Methods: Of the septic shock cases treated at the intensive care unit for ≥48 h, 131 adults who were diagnosed as septic AKI and underwent continuous venovenous hemodiafiltration were...

... Mojoli; Silvia Arpicco; Claudio Ronco Introduction: At the time of renal replacement therapy, approximately 20% of critically ill patients have septic shock. In this study, medium cutoff (MCO) continuous venovenous hemodialysis (CVVHD) was compared to high-flux membrane continuous venovenous...

...Juan Carlos Ruiz-Rodríguez; Luis Chiscano-Camón; Clara Palmada; Adolf Ruiz-Sanmartin; Marcos Pérez-Carrasco; Nieves Larrosa; Juan José González; Manuel Hernández-González; Ricard Ferrer The mortality of septic shock remains high [Ann Intensive Care. 2017;7:19], so apart from usual therapy based...

...Chieko Mitaka; Makio Kusao; Izumi Kawagoe; Daizoh Satoh; Toshiaki Iba; Claudio Ronco Introduction: Polymyxin B-immobilized fiber column direct hemoperfusion (PMX-DHP) is used for patients with septic shock, and the recommended hemoperfusion period is 2 h. However, it remains unclear whether...

...Kenji Fujimori; Kunio Tarasawa; Kiyohide Fushimi Introduction: Polymyxin B hemoperfusion (PMX) reduces endotoxin in septic shock patients’ blood and can improve hemodynamics and organ functions. However, its effects on the reduction of septic shock mortality are controversial. Methods: Using...

.... The authors have no conflicts of interest to declare. Blood purification Extracorporeal hemadsorption Cytokines Adsorption Animal model Immunosorbents Septic shock Endotoxin pumpless extracorporeal hemadsorption technique Arteriovenous extracorporeal hemadsorption technique In recent...

...Willem P. Brouwer; Servet Duran; Can Ince Background and Aims: It is currently unknown whether CytoSorb treatment for septic shock improves long-term survival beyond 28 days from intensive care unit (ICU) admission and which factors determine outcome. Methods: This was a long-term follow-up...

...Gabriele Amoruso; Nicola Di Venosa; Luigi Rizzi; Gianna Lupo; Armando Gisotti; Giuseppe Vitobello; Pasqua Mastrandrea; Rocco Petta; Gilda Cinnella Direct hemoperfusion using polymyxin B-immobilized fiber (PMX-DHP) is an established treatment method for septic shock caused by Gram-negative...

...Cem Kıvılcım Kaçar; Osman Uzundere; Deniz Kandemir; Abdulkadir Yektaş Introduction: Blood purification is an option for treatment of the source of sepsis when correcting patients’ septic shock-induced clinical status. We investigated the efficacy of HA330 hemoperfusion adsorbent application...

...Silvia De Rosa; Sara Samoni; Claudio Ronco We report a 49-year-old man, without prior medical history, consulted in the emergency department with a 5 day history of cough, fever, and dysuria. He was admitted to the intensive care unit due to septic shock. Critical care management was initiated...

.../septic shock underwent renal replacement therapy (RRT) for acute renal failure and haemoadsorption with Cytosorb as adjunctive therapy for 24 h. Measurements were taken at baseline, after 6 and 24 h: haemodynamic parameters, arterial and central venous blood gases, plasma levels of tumour necrosis factor...

... sepsis and can now be assessed by continuous measurement of urinary oxygen tension (PuO 2 ). Objectives: We aimed to test if PuO 2 measurements in patients with septic shock would be similar to those shown in experimental sepsis and would detect changes induced by the administration of furosemide. Method...

... and death. Extracorporeal blood purification techniques aim to improve the prognosis of these patients by modulating the unbalanced immune response. This study reports our experience with the use of the oXiris® membrane for septic shock patients requiring continuous renal replacement therapy (CRRT). Summary...

... of the disease process. A dysregulated cytokine response can lead to a hyper-inflammatory condition called a cytokine storm. This is believed to contribute to the pathophysiology of sepsis and septic shock, a condition carrying high morbidity and mortality in critically ill patients. Extracorporeal cytokine...

...: This analysis examined whether hemoperfusion therapy with a polymyxin B-immobilized fiber column lasting longer than 2 h (prolonged polymyxin) improved outcomes for patients with septic shock compared to 2-h polymyxin therapy (sub-analysis of data from the DESIRE trial). Results: The 2-h and prolonged polymyxin...

...Giorgio Berlot; Stefano Falini; Virginia Negro; Antoinette Agbedjro; Ariella Tomasini; Fulvio Iscra; Francesco Bianco; Ugo Gerini; Giuliano Boscutti Background: The extracorporeal removal of mediators is a rescue strategy for septic shock patients, which is still under investigation. Several...