... care practice. We discuss the basic technique characteristics and ex vivo investigations of the HA330/HA380 cartridge and summarize the latest clinical evidence regarding the use of HA330/HA380 hemoperfusion for the treatment of sepsis, severe COVID-19, cardiac surgery, acute pancreatitis, liver...

...Taku Furukawa; Yugeesh Lankadeva; Ian Baldwin; Pei Chen Connie Ow; Sally Hood; Antoine Schneider; Laurent A. Decosterd; Clive N. May; Rinaldo Bellomo Introduction: Hemoadsorption can be used as adjunctive therapy for sepsis. However, there is limited evidence regarding its antibiotic removal...

...-prevalence among critically ill patients with and without sepsis. Methods: In 328 patients (119 sepsis and 209 non-sepsis) admitted to our intensive care unit (ICU), we assessed heart rate at ICU admission, plasma neutrophil gelatinase-associated lipocalin (NGAL) and N-terminal pro-B-type natriuretic peptide...

... cartridge (PMX-HA) has never been described in abdominal sepsis. We aimed to compare the trend of three biomarkers in septic post-surgical abdominal patients in intensive care unit (ICU) treated with PMX-HA and their prognostic value. Methods: Ninety abdominal post-surgical patients were enrolled...

..., the adsorption abilities of TKM-101, AN69-ST, and control columns for cytokine-related sepsis in blood were compared using human serum samples. In the in vivo experiment, male Sprague-Dawley rats were anesthetized and injected with Escherichia coli endotoxin (15 mg/kg, intravenously). Afterward, the rats were...

... Hepcidin Continuous renal replacement therapy Sepsis Renal replacement therapy (RRT) is a common clinical intervention utilized in intensive care units in patients with acute kidney injury (AKI) or end stage kidney disease (ESKD) [ 1 ]. The life-sustaining capability of RRT is well understood...

...Taku Furukawa; Yugeesh Lankadeva; Ian Charles Baldwin; Pei Chen Connie Ow; Sally Hood; Clive May; Rinaldo Bellomo Introduction: Hemoadsorption has emerged as an adjunctive therapy for sepsis, but its impact on antibiotic levels remains poorly defined. We conducted an in vivo experimental study...

...Anna Lorenzin; Massimo de Cal; Matteo Marcello; David Sorbo; Sabrina Copelli; Claudio Ronco; Silvia de Rosa; Monica Zanella Introduction: Sepsis is a frequent complication in critically ill patients. Patients may require control of the source of infection, removal of pathogens and damaged cells...

... Hemoperfusion Critical illness Pharmacokinetics Sepsis Sepsis is a leading cause of morbidity and mortality in critically ill patients [ 1 ]. Antibiotics are essential to the treatment of sepsis; however, multidrug-resistant organisms present a growing challenge to effective management [ 2‒4...

...Céline Monard; Paul Abraham; Antoine Schneider; Thomas Rimmelé As highlighted by the last international consensus definition for sepsis and septic shock (sepsis-3), sepsis comes from a complex relationship between a pathogen and a dysregulated host response. To date, the treatment of sepsis...

...Alessandra Stasi; Rossana Franzin; Gianvito Caggiano; Rosa Losapio; Marco Fiorentino; Carlo Alfieri; Loreto Gesualdo; Giovanni Stallone; Giuseppe Castellano Acute kidney injury (AKI) is a common consequence of sepsis with a mortality rate of up to 40%. The pathogenesis of septic AKI is complex...

..., instructions or products referred to in the content or advertisements. CRRT Clotting Sepsis Sepsis is a leading cause of death in the intensive care unit (ICU) [1]. It is defined as organ dysfunction resulting from a dysegulated host response to infection [2]. Acute kidney injury (AKI...

...Girish Chandra Bhatt; Sidharth Kumar Sethi; Ira Mehta; Nikhil Nair; Ronith Chakraborty; Bhavya Sharma; Siddhartha Singh; Nikhita Kumar; Kabir Gulati; Rupesh Raina Background: Pediatric sepsis is a significant public health issue. This condition is exacerbated by rising serum creatinine...

...Mustafa Comoglu; Fatih Dede; Ezgi Coskun Yenigun; Canan Topcuoglu; Osman Inan; Enes Seyda Sahiner; Ihsan Ates Introduction: There is insufficient data on the role of the medium cutoff (MCO) membranes in the clearance of pro-inflammatory cytokines and oxidant radicals in patients with sepsis...

[email protected] 23 07 2020 22 08 2021 5 10 2021 Blood purification AN69-oXiris AN69-ST Sepsis Sepsis is a life-threatening condition caused by a dysregulated physiological response to an infection [1]. Currently, sepsis and the subsequent multiple organ dysfunction...

... in the ICU, his condition deteriorated with symptoms consistent with septic shock. Our report shows that the addition of a hemoadsorbent (CytoSorb) to the continuous renal replacement therapy circuit was associated with an improvement in the condition of our severely ill patient with abdominal sepsis...

... the optimal duration is 2 h or longer. The purpose of this study was to compare the effects of PMX-DHP between conventional and longer duration of PMX-DHP. Methods: We retrospectively investigated 103 patients with sepsis who underwent PMX-DHP. The demographic data, routine biochemistry, microbiological data...

...Andreas Körtge; Jolanta Majcher-Peszynska; Benjamin Heskamp; Reinhold Wasserkort; Steffen Mitzner Introduction: Continuous renal replacement therapies (CRRTs) are essential in the treatment of critically ill patients with acute kidney injury and are also discussed as a supporting sepsis therapy...

... of comorbidity (aHR 2.60, p = 0.013), and presence of abdominal sepsis (aHR 0.34, p = 0.004). A lactate level above 6.0 mmol/L at the start of CytoSorb therapy had a positive predictive value of 79% for mortality ( p = 0.013). Conclusions: Survival is achieved with CytoSorb and CRRT for patients with septic...

... for extracorporeal blood purification techniques in sepsis. Data Sources: A systematic search on MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials for RCTs was performed. Study Selection: RCTs investigating the effect of extracorporeal blood purification device use on mortality among critically...