...Faeq Husain-Syed; Raymond Vanholder; Mitchell H. Rosner; Hideki Kawanishi; Tammy Lisa Sirich; Claudio Ronco Progress in the identification and characterization of uremic retention solutes has refined our understanding of the pathophysiology of the uremic syndrome. Furthermore, the evolution...

... of the retained compounds as well as many of the pathophysiologic actions of the known retention solutes remain unknown. In this publication, we review recent information on uremic toxicity. Especially the difficulty to remove compounds, such as protein-bound compounds and larger molecules, seems to play...