...Toshihide Naganuma; Yoshiaki Takemoto; Naohiro Kamada; Daijiro Kabata; Ayumi Shintani; Keiko Ota; Jun Minakuchi; Ken Tsuchiya; Hideki Kawanishi Introduction: Recent advances in dialysis therapy have made it possible to remove middle molecules. Removal of small-middle molecules, such as β2...

... in modifying the old definition [ 16 ] were as follows: Dialysis Kidney disease Middle molecules Retention solutes Uremia The term uremia is generally used to describe the ill effects of advanced chronic kidney disease (CKD) caused by retained waste solutes and the complications of continued...

...Irena Rambabova Bushljetik; Lada Trajceska; Sefedin Biljali; Trajan Balkanov; Petar Dejanov; Goce Spasovski Background: A new medium cut-off (MCO) membranes has been designed to achieve better removal capacities for middle and large middle molecules in hemodialysis (HD) treatment. Aim: The aim...

... interesting removal capacities for middle and large middle molecules in hemodialysis (HD) treatments. The few studies published to date have reported contradictory results regarding middle-sized molecules when comparing MCO dialyzers versus dialyzers used in online hemodiafiltration (OL-HDF). Methods...

..., in the case of prolactin, the reduction ratio with HDF was 45 and 61% with HDx ( p < 0.001). Conclusions: We conclude that HDx is not inferior to online hemodiafiltration in the clearance of small and middle molecules and could be superior in the clearance of larger middle molecules. We conducted...

... to be rather non-toxic, an optical monitoring technique that is suitable for middle molecule removal could be a valuable complement to urea-based dialysis dose parameters. The aims of the present study were (i) to determine the best optical wavelength for β2-M by correlation analyses both in HD and HDF, (ii...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Dialysis fluid Hemodiafiltration Membranes Middle molecules MudPIT Permeability Proteomics Urea equilibrated Kt/V (eKt/V) was calculated with the equation: eKt/V = (K...

...). Conclusions: This study demonstrates that treating patients with an FX CorDiax 60 instead of an FX 60 dialyzer in post-dilution HDF mode significantly increases the elimination of middle molecules. [email protected] 27 09 2013 22 12 2013 20 3 2014 © 2014 S. Karger AG, Basel...

...Julius J. Schmidt; Carsten Hafer; Christian Clajus; Johannes Hadem; Gernot Beutel; Bernhard M.W. Schmidt; Jan T. Kielstein Background: Accumulation of middle molecules is thought to have adverse effects in patients with acute kidney injury (AKI). Elimination of middle molecules by non-convective...

... in continuous venovenous hemodiafiltration, reducing the impact of dose adjustment. The dosing arms in the Acute Renal Failure Trial Network (ATN) study may have delivered similar clearances for middle molecules. Methods: We simulated the 2 CRRT doses in the ATN study using a synthetic polydisperse...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. High cut-off membranes Haemodialysis β 2 -Microglobulin Middle molecules Albumin Original Paper Blood Purif 2009;28:365 372 DOI: 10.1159...

..., inactivate nitric oxide, and exert a number of toxic effects on endothelial cells. Loss of normal renal function has been found recently to cause a marked increase in the circulating levels of plasma AGEs, suggesting that these moieties may comprise one component of the so-called uremic ‘middle molecules...

..., significant advances have been made in the structural and functional characterization of toxic uremic solutes that are in the higher molecular size range (‘middle molecules’). Several lines of evidence suggest that, in addition to small solutes, removal of middle molecules is also advantageous. The potential...