... situations for instance antithrombotic medications in patients requiring emergency surgery or in case of accidental or self-induced intoxication. In this review, we summarize available in vitro, in vivo, and clinical studies reporting on the influence of various HA techniques on drugs pharmacokinetics. Key...

... overdose where serum protein binding is saturated. This report presents a case of CBZ intoxication where we were able to compare the mass removal of CBZ using hemoperfusion, with the mass removal of CBZ achieved with continuous renal replacement therapy (CRRT) during combined treatment. Methods: The Jafron...

...Caterina Reuchsel; Falk Alexander Gonnert Severe intoxication with the anti-epileptic drug, lamotrigine can cause cardiovascular collapse, neurotoxicity – expressed as intractable seizures, and even death. As there is currently no known specific antidote, extracorporeal removal therapies...

...Thomas Georg Karl Breuer; Daniel Robert Quast; Stephan Wiciok; Adnan Labedi; Gisa Ellrichmann While several intoxications can be successfully treated with specific antidotes, intoxications with the steroid glycoside digitoxin still represent a major challenge. Besides conventional approaches...

...Fiorenza Ferrari; Alessandro Carletti; Nicola Peroni; Silvia Mongodi; Pasquale Esposito; Anita Orlando; Francesco Mojoli; Claudio Ronco; Mirko Belliato; Giorgio A. Iotti We describe the case of a 49-year-old woman with a Tramadol intoxication associated with multiorgan failure. Veno-arterial femoro...

... shock Resuscitation Extracorporeal membrane oxygenation Extracorporeal life support Intoxication Cytokines Hemoadsorption Cytosorb The use of extracorporeal membrane oxygenation (ECMO) for mechanical support during severe acute heart failure, lung failure and shock has increased...

... involve the treatment of inflammatory conditions, chronic uremic symptoms, and autoimmune disease, in addition to intoxication, which was once considered the classical indication for adsorption therapy. HA130, HA230, and HA330 (Jafron, Zhuhai City, China) are among the widely used adsorption cartridges...

...Alper Azak; Gülay Koçak; Bülent Huddam; Murat Duranay Hemodialysis (HD) is a technique that helps in the management of drug intoxications/overdoses – the most important point being the protein-binding rate of the molecules which have to be cleared. In cases where the drug is not bound...

..., systemic bleeding is a major factor to predict adverse outcome. Charcoal Hemoperfusion Intoxication Toxicology © 2010 S. Karger AG, Basel 2010 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

...Ja-Liang Lin; Paik-Seong Lim We have investigated the efficacy of a pumpless hemoperfusion technique, continuous arteriovenous hemoperfusion (CAVHP) in 3 cases of acute intoxications with meprobamate, theophylline and phenobarbital. Dramatic responses were noted in both hemodynamic unstable...

... (mean maximum serum creatinine level 618 µmol/l). Upon discharge, serum creatinine levels were still elevated in 10 patients. In all but 1 patient, renal function completely normalized within 20 months after intoxication. Conclusion: Adult men are the most endangered segment of the population. The most...

... could have great impact on detoxification treatment in exogenous intoxications. We performed an in vitro evaluation of a newly developed highly biocompatible sorbent cartridge (Betasorb ® ), examining its adsorptive capacity concerning therapeutic drugs. Methods: Uremic blood spiked with a range...