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Keywords: Endotoxin
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Journal Articles
Subject Area:
Nephrology
Blood Purif (2024) 53 (1): 61–70.
Published Online: 08 November 2023
..., the adsorption abilities of TKM-101, AN69-ST, and control columns for cytokine-related sepsis in blood were compared using human serum samples. In the in vivo experiment, male Sprague-Dawley rats were anesthetized and injected with Escherichia coli endotoxin (15 mg/kg, intravenously). Afterward, the rats were...
Journal Articles
Subject Area:
Nephrology
Blood Purif (2024) 53 (1): 30–39.
Published Online: 02 November 2023
...Sian E. Piret; Sobia Khan; Fabliha Fairuz; Samaneh Gholami; Merin Davis; Chang Kyung Kim; Melissa Espinoza; Debra Foster; John A. Kellum; Sahar Ahmad; Andreas P. Kalogeropoulos; Sandeep K. Mallipattu Introduction: Endotoxin is a key driver of sepsis, which frequently causes acute kidney injury (AKI...
Journal Articles
Subject Area:
Nephrology
Blood Purif (2022) 51 (10): 831–839.
Published Online: 12 January 2022
..., an endotoxin retentive filter (ETRF) is used in the final step of dialysis fluid purification, with the aim of preventing leakage of endotoxins. Sodium hypochlorite and peracetic acid are used as disinfecting agents for the dialysis fluid pipes containing the ETRF; however, the effects of these agents on ETRF...
Journal Articles
Journal Articles
Blood Purif (2021) 50 (2): 222–229.
Published Online: 26 November 2020
.... The incidence of infectious complications in pediatric cardiac surgery is known to be approximately 15–30%. The main etiological factor of sepsis is endotoxin. Aim: To evaluate the efficiency and safety of polymyxin (PMX) B-immobilized column-direct hemoperfusion in complex intensive therapy of sepsis...
Journal Articles
Subject Area:
Nephrology
Blood Purif (2020) 49 (4): 502–508.
Published Online: 19 December 2019
..., including mechanical ventilation and vasopressors. Endotoxic shock was suspected (endotoxin activity assay [EAA] 0.75), and 2 treatments with Polymyxin B hemoperfusion (Toraymyxin®, Toray Medical Co., Ltd., Tokyo, Japan) were performed in 48 h, alternate with high-volume hemofiltration sessions. Initial...
Journal Articles
Subject Area:
Nephrology
Blood Purif (2019) 47 (Suppl. 3): 16–22.
Published Online: 12 April 2019
..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute kidney injury Blood purification Endotoxin Intensive care unit Sepsis...
Journal Articles
Subject Area:
Nephrology
Blood Purif (2019) 47 (Suppl. 3): 51–53.
Published Online: 12 April 2019
...Marcus Ewert Broman; Mikael Bodelsson Background: Lipopolysaccharide (endotoxin) from the outer Gram-negative bacterial wall can induce a harmful immunologic response, involving hemodynamic deprivation, and is one important motor driving the septic cascade. The positively charged poly-imine...
Journal Articles
Subject Area:
Nephrology
Blood Purif (2019) 47 (1-3): 94–100.
Published Online: 25 September 2018
.... Endotoxin Extracorporeal therapy Adsorption Sepsis Uremia Intoxication Sorbents Extracorporeal blood purification therapy for the removal of exogenous and endogenous toxins is a rapidly evolving area. The main membrane-based mechanisms by which solutes are removed are diffusion (driven...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Blood Purif (2017) 44 (4): 314–326.
Published Online: 22 November 2017
... opportunities of innovative therapeutic approaches. Endotoxin plays a pivotal role in the pathogenesis of multi-organ dysfunction in the setting of gram-negative sepsis. Indeed, heart and kidney impairments seem to be induced by the release of circulating pro-inflammatory and pro-apoptotic mediators triggered...
Journal Articles
Subject Area:
Nephrology
Blood Purif (2017) 44 (1): 51–59.
Published Online: 28 February 2017
...Jonathan Wong; Philip Davis; Ashish Patidar; Yonglong Zhang; Enric Vilar; Malcolm Finkelman; Ken Farrington Background: In healthy individuals, an acute inflammatory response occurs after intense exercise due to gut ischaemia and intestinal bacterial endotoxin translocation into the bloodstream...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Nephrology
Blood Purif (2014) 37 (1): 39–46.
Published Online: 05 February 2014
... inflammatory response syndrome + infection site + failure of two or more organs) together with endotoxin activity assay (EAA) ≥0.6 and procalcitonin (PCT) levels ≥2 ng/ml. Antimicrobial therapy was initiated in the first hour after the diagnosis of severe sepsis and extracorporeal therapy was initiated within...
Journal Articles
Subject Area:
Nephrology
Blood Purif (2014) 37 (Suppl. 1): 9–13.
Published Online: 20 January 2014
...Dinna N. Cruz Endotoxin, one of the principal components on the outer membrane of Gram-negative bacteria, is considered a key and early component in the pathogenesis of sepsis. Polymyxin B bound to polystyrene fibers (PMX) is a medical device capable of removing circulating endotoxin by adsorption...
Journal Articles
Subject Area:
Nephrology
Blood Purif (2012) 34 (2): 164–170.
Published Online: 24 October 2012
...Hiroyuki Hirasawa; Shigeto Oda; Masataka Nakamura; Eizo Watanabe; Hidetoshi Shiga; Kenichi Matsuda Since the introduction of the new pathophysiological concept of pathogen-associated molecular patterns (PAMPS) and alarmins, endotoxin has been recognized as only one of the PAMPS. It is widely...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Nephrology
Blood Purif (2011) 31 (4): 268–275.
Published Online: 13 January 2011
...Hiroki Suzuki; Hirokazu Honda; Noriyuki Kato; Tetsuo Michihata; Keiko Takahashi; Kanji Shishido; Tadao Akizawa Background: We estimated the flow of endotoxins (ET) from dialysates into the blood of patients on hemodialysis (HD) using limulus amebocyte lysate (LAL) assays and endotoxin activity (EA...