...Antonella Cotoia; Valeria Parisano; Paola Sara Mariotti; Vincenzo Lizzi; Giuseppe Stefano Netti; Elena Ranieri; Francesco Forfori; Gilda Cinnella Introduction: Comparison of the marker kinetics procalcitonin, presepsin, and endotoxin during extracorporeal hemoperfusion with polymyxin-B adsorbing...

..., the adsorption abilities of TKM-101, AN69-ST, and control columns for cytokine-related sepsis in blood were compared using human serum samples. In the in vivo experiment, male Sprague-Dawley rats were anesthetized and injected with Escherichia coli endotoxin (15 mg/kg, intravenously). Afterward, the rats were...

...Sian E. Piret; Sobia Khan; Fabliha Fairuz; Samaneh Gholami; Merin Davis; Chang Kyung Kim; Melissa Espinoza; Debra Foster; John A. Kellum; Sahar Ahmad; Andreas P. Kalogeropoulos; Sandeep K. Mallipattu Introduction: Endotoxin is a key driver of sepsis, which frequently causes acute kidney injury (AKI...

..., an endotoxin retentive filter (ETRF) is used in the final step of dialysis fluid purification, with the aim of preventing leakage of endotoxins. Sodium hypochlorite and peracetic acid are used as disinfecting agents for the dialysis fluid pipes containing the ETRF; however, the effects of these agents on ETRF...

..., instructions or products referred to in the content or advertisements. 2021 Endotoxin Sepsis Septic shock Polymyxin B-immobilized fiber Treatment duration Vasoactive-inotropic score Sepsis is defined as the life-threatening organ dysfunction caused by a dysregulated host response...

.... The incidence of infectious complications in pediatric cardiac surgery is known to be approximately 15–30%. The main etiological factor of sepsis is endotoxin. Aim: To evaluate the efficiency and safety of polymyxin (PMX) B-immobilized column-direct hemoperfusion in complex intensive therapy of sepsis...

..., including mechanical ventilation and vasopressors. Endotoxic shock was suspected (endotoxin activity assay [EAA] 0.75), and 2 treatments with Polymyxin B hemoperfusion (Toraymyxin®, Toray Medical Co., Ltd., Tokyo, Japan) were performed in 48 h, alternate with high-volume hemofiltration sessions. Initial...

...Marcus Ewert Broman; Mikael Bodelsson Background: Lipopolysaccharide (endotoxin) from the outer Gram-negative bacterial wall can induce a harmful immunologic response, involving hemodynamic deprivation, and is one important motor driving the septic cascade. The positively charged poly-imine...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute kidney injury Blood purification Endotoxin Intensive care unit Sepsis...

... to in the content or advertisements. Endotoxin Extracorporeal therapy Adsorption Sepsis Uremia Intoxication Sorbents Among the recently developed group of adsorption cartridges are the HA resin hemoperfusion (HP) cartridges, HA130, HA230, and HA330 (Jafron, Zhuhai City, China). To date...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Endotoxin Hemoperfusion therapy Optimal duration Septic shock Toraymyxin Fig. 1. Patient selection flowchart. DESIRE, Dexmedetomidine for Sepsis in the Intensive care unit...

... opportunities of innovative therapeutic approaches. Endotoxin plays a pivotal role in the pathogenesis of multi-organ dysfunction in the setting of gram-negative sepsis. Indeed, heart and kidney impairments seem to be induced by the release of circulating pro-inflammatory and pro-apoptotic mediators triggered...

...Jonathan Wong; Philip Davis; Ashish Patidar; Yonglong Zhang; Enric Vilar; Malcolm Finkelman; Ken Farrington Background: In healthy individuals, an acute inflammatory response occurs after intense exercise due to gut ischaemia and intestinal bacterial endotoxin translocation into the bloodstream...

...Maurizio Bossola; Enrico Di Stasio; Maurizio Sanguinetti; Brunella Posteraro; Manuela Antocicco; Gilda Pepe; Enrica Mello; Francesca Bugli; Carlo Vulpio Background: This study aims to evaluate, in patients on chronic hemodialysis (PHD), the levels of endotoxin through a chemiluminescent bioassay...

... cascade induced by endotoxin [ 17,18,19,20,21,22 ]. Therefore, it can be hypothesized that removing endotoxin is more beneficial for septic shock patients complicated with AKI than those without that complication. We planned this study to assess the survival benefit of PMX in septic shock patients...

... inflammatory response syndrome + infection site + failure of two or more organs) together with endotoxin activity assay (EAA) ≥0.6 and procalcitonin (PCT) levels ≥2 ng/ml. Antimicrobial therapy was initiated in the first hour after the diagnosis of severe sepsis and extracorporeal therapy was initiated within...

...Dinna N. Cruz Endotoxin, one of the principal components on the outer membrane of Gram-negative bacteria, is considered a key and early component in the pathogenesis of sepsis. Polymyxin B bound to polystyrene fibers (PMX) is a medical device capable of removing circulating endotoxin by adsorption...

...Hiroyuki Hirasawa; Shigeto Oda; Masataka Nakamura; Eizo Watanabe; Hidetoshi Shiga; Kenichi Matsuda Since the introduction of the new pathophysiological concept of pathogen-associated molecular patterns (PAMPS) and alarmins, endotoxin has been recognized as only one of the PAMPS. It is widely...

... lower left abdominal pain, high fever (40°C) and gross hematuria. Her endotoxin and high-mobility group box-1 protein (HMGB1) levels were extremely elevated. Her blood pressure was 68/36 mm Hg. Urinalysis revealed innumerable white blood cells (WBCs). Blood and urine cultures were positive...

...Kearkiat Praditpornsilpa; Khajohn Tiranathanagul; Paweena Susantitaphong; Pisut Katavetin; Thananda Trakarnvanich; Natavudh Townamchai; Talerngsak Kanjanabuch; Yingyos Avihingsanon; Kriang Tungsanga; Somchai Eiam-Ong Background: In Thailand, dialysate endotoxin contamination levels vary from less...