... Cytokines Inflammation Hemoadsorption Hemoperfusion Sepsis is a life-threatening syndrome caused by an immune response that leads to organ damage. Mortality from sepsis is estimated at around 11 million each year, with an incidence of nearly 50 million cases worldwide [ 1 ]. The origin...

... inflammatory cytokine levels and decreased postoperative complications. Methods: A retrospective observational cohort study was conducted between March 1, 2021, and February 28, 2022. Patients with ATAAD undergoing emergent total arch replacement surgery were divided into the control (CON) and HA groups...

... failure and systemic immunological involvement with consequent inflammation-mediated injury. Indeed, the most important determining factor of COVID-19 severity is the strength of the so-called “cytokine storm” associated with SARS-CoV-2 infection. Therefore, this severe infection varies clinically from...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Artificial organ Cytokines Extracorporeal membrane oxygenation Hemoperfusion Inflammation Inflammatory mediators Mechanical circulatory support Shock...

... was to investigate whether cytokine levels before the initiation of ECMO treatment could predict AKI. We also aimed to investigate the impact of AKI on 30-day and 1-year mortality. Methods: Serum cytokine levels were analyzed in 100 consecutive VA-ECMO-treated patients at pre-cannulation, at 48 h post-cannulation...

...Sevda Onuk; Aynur Karayol Akin; Ali Sari; Kursat Gundogan; Gulden Baskol; Kudret Dogru; Murat Sungur Introduction: Blood purification therapy is a method used to enable cytokine removal and to improve disturbed immune homeostasis in patients with sepsis or septic shock. This study aimed to evaluate...

... dose, and ICU and hospital mortality within 28 days. Further secondary endpoints included reduction (≥20%) of IL-6, PCT and MR-pro-ADM within 10 days after randomization. In severe COVID-19, a dysregulated systemic immune overactivation causes the elevation of inflammatory cytokines [ 10, 11...

... kidney injury Cytokines Medium cutoff membranes Renal replacement therapy At the time of renal replacement therapy (RRT), 19.1% of critically ill patients have been reported to have septic shock [1, 2]. Extracorporeal blood purification (EBP) clears toxins and solutes generally not removable...

...Jin-Yu Peng; Lu Li; Xu Zhao; Feng Ding; Xiaotong Hou; Zhiyong Peng Introduction: Systematic inflammatory response occurred in some critically ill patients with COVID-19. Cytokine reduction by hemadsorption is a mechanism of treatment. However, whether CytoSorb hemoperfusion works for critically ill...

...Mascha O. Fiedler; Christian Reyher; Armin Kalenka; Caroline Rolfes; Christopher Lotz; Ralf M. Muellenbach In recent years, extracorporeal hemadsorption (HA) techniques capable of adsorbing pro- and anti-inflammatory cytokines are increasingly used in various clinical situations. The therapeutic...

...Serkan Feyyaz Yalın; Mehmet Rıza Altıparmak; Mevlut Tamer Dincer; Serap Yadigar; Ahmet Murt; Ergun Parmaksiz; Claudio Ronco Introduction: Severe acute respiratory syndrome coronavirus-2 may lead to high levels of expression of inflammatory cytokines. Medium cut-off (MCO) membranes may make greater...

... purification in attenuating the consequences of the post-resuscitation syndrome. Blood purification can decrease the cytokine storm particularly when using a CytoSorb absorber. Acrylonitrile 69-based oXiris membranes can remove endotoxin and high-mobility group box 1 protein. Blood purification techniques can...

... as an example of uncontrolled inflammatory cascade and hypercytokinemia effectively treated with CPFA. CPFA is an extracorporeal therapy able to clear cytokines and other medium-high molecular weight molecules from plasma. According to the peak concentration hypothesis , postulated by Ronco et al. [ 10...

...Kentarou Hayashi; Yusuke Sasabuchi; Hiroki Matsui; Mikio Nakajima; Hiroyuki Ohbe; Kazuyuki Ono; Hideo Yasunaga Introduction: Sepsis is a systemic inflammatory response syndrome caused by infectious diseases, with cytokines possibly having an important role in the disease mechanism. Acrylonitrile-co...

...Stephan Harm; Claudia Schildböck; Jens Hartmann Background/Aims: Cytokines are among the main target substances that have to be removed effectively in order to improve the patient’s health status in the treatment of sepsis, septic shock, and liver diseases. Although there are various medical...

... inflammatory mediators during sepsis, thus improving outcome. Objectives: We aimed to evaluate changes in cytokines, haemodynamics and microcirculation during blood purification with Cytosorb adsorber in septic patients. Methods: Prospective observational study on critically ill adult patients with sepsis...

... are lacking. Recently, a new polystyrene-based device for hemoadsorption, which aims to reduce excessive levels of inflammatory molecules such as interleukins, cytokines as well as damage- and pathogen-associated molecular patterns, has become available. Here we summarize the rationale, available data...

... with both systemic heparin and regional citrate anti-coagulation. The typical duration of therapy is up to 24 h per session, daily for 2–7 consecutive days. Blood flow is set in the range of 150–700 mL/min. CS use is indicated in clinical conditions with cytokines elevation. It is effective in targeting...

... to December 2018 have been reviewed. The adsorbing membrane oXiris® (Baxter, IL, USA) was used through a Prisma plataform (Prismaflex – Baxter, IL, USA). At basal time (T0), at 24 h (T1), and at the end of the treatment (T2) were analyzed the clinical data, the cytokines, and the time course of endotoxin...

... (AKI). Endotoxins and cytokine levels are associated with the occurrence and severity of AKI, and different blood purification devices are available to remove them from circulation. One such device, oXiris, is a hollow-fibre purification filter that clears both endotoxins and cytokines. Due to limited...