... diagnosis quickly can lead to a delay in initiating renal-preserving and sometimes life-saving treatment. Currently, both the treatment plan and the prognosis vary substantially according to the presumed diagnosis. The availability of anti-complement therapy makes differentiating the cause of the hemolytic...

...L. Lundberg; B.G. Stegmayr Transfusion may cause immunization. By leukocyte filtration the cells are trapped into the filter which in part is due to activation. We compared the extent of blood corpuscle damage and complement activation after filtration through four different leukocyte-removal...

...Flemming Knudsen; Arne Høj Nielsen; Jens Oluf Pedersen; Casper Jersild Complement activation during hemodialysis is related to dialysis discomfort and hypoxemia, and has been suggested to contribute to the occurrence of hypersensitivity-like symptoms, increased cardiovascular morbidity and chronic...

... decreased during dialysis with CP, but was unchanged with PC membranes. Platelet injury, reflected by decreased platelet aggregation and increase in plasma β-thrombo-globulin, occurred equally with both membranes. Complement activation (C3d and C5a), leukopenia and release of granulocyte-derived elastase...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hemodialyzers Polycarbonate Plate dialyzers Clearances Complement Membrane Biocompatibility Polycarbonate-Workshop, Amsterdam 1985 Blood Purification 4: 63-73 (1986) © 1986 S...

...Lee W. Henderson; Dennis E. Chenoweth; James H. Shinaberger; Joseph Miller; Peter Konstantin Clinical as well as laboratory studies have been employed to assess the complement activating potential of polycarbonate membrane hemodialyzers. Blood samples from a group of patients undergoing sequential...

... with significant plasma C5a generation. Polycarbonate promoted the same trend of changes in both parameters but significantly less pronounced, while polyacrylonitrile did not affect leukocyte counts nor plasma C5a levels. These data suggest that complement-derived C5a generation may be an important factor...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Biocompatibility Cellulosic membranes Complement Elastase Lactoferrin...

... in any parameter studied and no patient exhibited symptoms related to complement activation. We conclude that the Renaflo filter is safe for use during continuous arteriovenous hemofiltration. Although clinically insignificant, there is a detectable activation of C3 by polysulfone membranes. 29 08...

... transport of fluid and solutes. The blood-membrane contact induced complement activation (rise in C3d) and transient leukopenia, as described during clinical hemodialysis. Pa O2 , Pa CO2 and calculated oxygen uptake remained unchanged. Heart rate, cardiac index (thermodilution), systemic vascular resistance...

... bioincompatibility. We used an experimental dialysis model to evaluate, by chemiluminescence, the production of reactive oxygen metabolites and, by C3a, complement activation induced by cuprophan, cellulose acetate, hemophan, polysulfone, polyacrylonitrile, polymethylmethacrylate or polyvinyl chloride blood lines...

...Flemming Knudsen The present report summarizes our previous experience with the effect of various dialyzer membranes on leukocyte count, plasma C3d and C5a/C5a des-Arg , and total hemolytic complement. A relationship between the formation of C5a/C5a des-Arg within the dialyzer and hemodialysis...

... into the animals produces drastic hematologic and cardiopulmonary alterations. Available data suggest that these alterations are mediated by complement activation products and arachidonic acid metabolites. The consistent and sensitive nature of these models makes them useful tools to further study the interactions...

... of biocompatibility of hemodialysis membranes to the complement system is given as a possible model to which other foreign surfaces may be compared. 29 10 2008 © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may...

...James K. Kirklin; Eugene H. Blackstone; John W. Kirklin Despite the widespread safe application of cardiopulmonary bypass (CPB) for cardiac surgery, it is inherently a pathologic state. CPB produces a generalized inflammatory reaction involving at least the complement, coagulation, kallikrein...

... to enhance interleukin-1 (IL-1) production of murine peritoneal macrophages and the ability to activate the complement cascade in fresh adult human serum. Not only bacterial LPS and cell walls or peptidoglycans but also their structural components with appropriate size and structure induced IL-1 production...

...Maria P. Varela; Paul L. Kimmel; Terry M. Phillips; Gary J. Mishkin; Susie Q. Lew; Juan P. Bosch Hemodialysis (HD) membrane biocompatibility is defined as absence of complement activation. We have recently shown that circulating levels of interleukin (IL) 1 and IL-2 predict death and survival...

... subpopulations, T-cell activation markers (CD69, CD25, HLA-DR, CD54, CD62L, CD45RO, CD11a, CD28), complement-activation products (C3a) and serum elastase were measured at 0, 3, 6 and 12 months in the two patient groups and compared to 13 healthy control subjects. Results: Over dialysis time, all patients showed...