... applied to highly complex patients, with rapidly changing clinical needs. To promote precision medicine in the field of renal replacement therapy and encourage dynamic prescription, the Acute Dialysis Quality Initiative (ADQI) recommends periodically measuring the solutes extracorporeal clearance...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Dialysis Renal replacement therapy Membrane characteristics Clearance Filtration Flux Standardized...

... and inflammatory cytokines that lead to deleterious effects upon the body. The current standard of care involves the use of continuous kidney replacement therapy to remove harmful cytokines until the body returns to homeostasis. In order to promote faster clearance and reduced stay in the ICU, high-volume...

...Caleb Fisher; Ian Baldwin; Nigel Fealy; Thummaporn Naorungroj; Rinaldo Bellomo Introduction: Continuous renal replacement therapy (CRRT) can be used to treat hyperammonaemia. However, no study has assessed the effect of different CRRT techniques on ammonia clearance. Methods: We compared 3...

...Thummaporn Naorungroj; Fumitaka Yanase; Glenn M. Eastwood; Ian Baldwin; Rinaldo Bellomo Introduction: Hyperammonemia is a life-threatening condition. However, clearance of ammonia via extracorporeal treatment has not been systematically evaluated. Methods: We searched EMBASE and MEDLINE databases...

.... Recently, new dialysis membranes have allowed clearance of solutes with higher molecular weight, without significant albumin losses high-retention-onset-HD (HRO-HD). Methods: Prospective crossover trial, in which 16 prevalent patients switched from high-flux HD (HF-HD) to online hemodiafiltration (olHDF...

...Guiyan Li; Li Zhang; Haibin Ren; Baodi Huang; Chunxia Mao; Annan Zhou Objective: This retrospective study aimed to investigate the clearance of magnesium (Mg) in peritoneal dialysis (PD) patients and its influencing factors. Methods: The demographic information, clinical characteristics...

..., for the patient solution at the beginning (t0 ′ ) and at the end of this phase (t30 ′ ), and for the PBP solution (for HCO-CVVHDF set of experiments). Furthermore, clearances and mass removal have been calculated considering the solutes concentrations and flows in the inflow, outflow, and effluent lines...

... polysulfone membranes. Methods: Data were obtained for solute clearance and sieving coefficients of vitamin B 12 and a range of polydisperse dextrans using ATA™ SOLACEA-25H and Optiflux F250NR polysulfone dialyzers. Results for these, and the CT190 symmetric cellulose triacetate dialyzer, were analyzed using...

... established. While continuous renal replacement therapy (CRRT) is widely understood to have greater solute clearance capabilities relative to intermittent therapies, neither urea nor any other solute is specifically employed for CRRT dose assessments in clinical practice at present. Instead, the normalized...

... dysregulation of mineral bone metabolism; however, the impact and clearance of mineral bone metabolism factors during dialysis remain largely undescribed. Methods: In a cross-sectional study, 10 chronic hemodialysis patients were treated with hemodialysis for 8 h using a high-flux filter and a dialysate bath...

...Susan J. Lewis; Lynn A. Switaj; Bruce A. Mueller Background/Aims: To study transmembrane clearance (CL TM ) and adsorption of tedizolid, a novel oxazolidinone antibiotic, in continuous hemofiltration (CVVH) and continuous hemodialysis (CVVHD). Methods: In vitro CVVH/CVVHD models with polysulfone...

...Xia Tao; Stephan Thijssen; Nathan Levin; Peter Kotanko; Garry Handelman Background: Indoxyl sulfate is a protein-bound uremic toxin and its dialytic clearance is comparatively low. We propose a method to increase indoxyl sulfate dialytic clearance. Methods: Human serum albumin, preloaded...

... kinetics during these therapies remains limited. Methods: Previously published phosphorus kinetic data during HDF and HD were analyzed using a pseudo-one-compartment kinetic model. Phosphorus mobilization clearance (K M ) and dialyzer phosphorus clearance (K d ) were simultaneously estimated from measured...

...Casey N. Gashti; Roger A. Rodby; Zhongping Huang; Dayong Gao; Weiming Zhang Background/Aims: In pre-dilution hemofiltration (HF), solute clearance is less than the HF rate. While the amount of this loss is predictable, it has not been validated in high-volume HF associated with high blood flow...

... and clearance properties. However, hemodiafilter performance over time has not been assessed. We investigated solute clearance over time in modeled CRRT. Methods: In vitro continuous hemofiltration (CH) and continuous hemodialysis (CD) were operated for 48 h using AN69 polyacrylonitrile, cellulose triacetate...

... solute removal, on-line measurement of ionic clearance to monitor small solute removal and real-time data processing to guide the delivery of therapy. In addition, these machines feature feedback control systems that may help reduce the unpleasant side effects associated with fluid removal during...

... are underdialyzed. While increasing small solute clearance by dialysis using urea kinetics as a guide improves clinical outcome, ‘adequate’ treatment using current techniques is only an arbitrary definition, since solute removal by dialysis remains far inferior to that of the normal native kidneys. In recent years...

... reuse Clearance Water purification Abstract Limitations of dialyzer reuse technology may contribute to adverse patient outcomes. Assessing changes in dialyzer per­ formance by measuring changes in total cell volume may not be valid for all membranes and reprocessing methods. Systems which determine...

...Kyun Il Park; Tadao Tomoyoshi The effects of the low dialysate flow rates on the removal rate and clearance of urea nitrogen, creatinine, uric acid, β 2 -microglobulin and myoglobin, using high flux membranes were studied. The removal rates for all substances were not significantly decreased...