... or regional citrate anticoagulation (RCA). The 2012 Kidney Disease Improving Global Outcomes guidelines support the use of RCA as the first-line strategy in patients requiring CRRT, with and without bleeding risk. Implementing RCA in the intensive care unit (ICU) implies involving all medical and nursing...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2024 Citrate Calcium Continuous...

... replacement therapy (CRRT) is recommended for metformin removal in critically ill patients. According to current guidelines, regional citrate anticoagulation (RCA) is the first-line strategy. However, since metformin also inhibits citrate metabolism, a risk of citrate accumulation could be hypothesized...

...), and hemodiafiltration (CVVHDF) modes. However, to date, there is no validated protocol to guide the use of Omni® in CVVHDF mode with regional citrate anticoagulation (RCA). Methods: We designed a protocol for CVVHDF-RCA tailored for Omni®. This protocol was tested in patients included in an observational study...

...Michael Robert Halpin; Bonny Chen; Richard Francis Singer Introduction: To assess the safety, efficacy, and calcium flux of an accelerated algorithm for regional citrate anticoagulation in membrane-based plasma exchange. Methods: This was an observational study in patients receiving citrate...

...Chris M. Anstey; Fraser D. Russell Background: Continuous renal replacement therapy (CRRT) with regional citrate anticoagulation (RCA) is now commonly used to treat acute kidney injury in critically ill patients. The concentration of citrate is not routinely measured, with citrate accumulation...

...Sebastien Redant; David De Bels; Jacques Massaut; Dragos Barglazan; Precieux M. Lebitasy; Patrick M. Honoré Background: Correcting hyponatremia too quickly can lead to osmotic demyelination syndrome. During citrate dialysis, a significant sodium load is brought to the prefilter. We reviewed...

... kidney injury (AKI) and mortality. Sustained low-efficiency dialysis (SLED) combines the cardiovascular stability of continuous therapy with the operational facility of conventional hemodialysis (HD). Citrate has become an alternative to heparin in anticoagulation because it favors the maintenance...

... for necessary surgeries or blood transfusions. Our objective was to demonstrate a feasible self-circulation anticoagulation protocol based on citrate (CSAP) to address discontinuity during CRRT. Methods: We conducted a prospective observational study of 57 pediatric patients undergoing 88 CRRT sessions...

.... Acute kidney injury Citrate Continuous hemodiafiltration Critical care Dialysis efficiency Dialysis machine Hemodiafiltration Since the seminal paper by Ronco et al. [ 1 ] showing that survival among AKI patients was improved by increased continuous veno-venous hemofiltration dose, most...

...Dana Mahmood; Bernd G. Stegmayr Anticoagulation with citrate-containing haemodialysate (cHD) is an alternative to tinzaparin haemodialysate (tHD). The study investigated whether cHD would differ when changed from tHD. The same 18 patients were their own controls followed up with cHD for 5 months...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute kidney injury Citrate Continuous hemofiltration Continuous renal replacement therapy Critical care Dialysis efficiency Dialysis machine Haemodiafiltration...

... replacement therapy (CRRT) in preventing CRRT-related hypophosphatemia. Methods: In heart surgery patients undergoing continuous veno-venous haemodiafiltration (CVVHDF) with regional citrate anticoagulation (RCA), we combined an 18 mmol/l citrate solution with a phosphate-containing (1.2 mmol/l) dialysate...

... for regional citrate anticoagulation (RCA) using standard bicarbonate buffered, calcium containing replacement solution with acid citrate dextrose formula-A as a citrate source. Our objective was to demonstrate that the protocol was safe and effective. Methods: Prospective audit of consecutive patients...

...Rita Jacobs; Patrick M. Honoré; Sean M. Bagshaw; Marc Diltoer; Herbert D. Spapen Introduction: We conducted an 8-month prospective single-center observational study in patients with acute kidney injury treated with continuous veno-venous hemofiltration (CVVH) to compare the impact of two citrate...

...Buyun Wu; Kaiyue Zhang; Bin Xu; Daxi Ji; Zhihong Liu; Dehua Gong Background/Aims: To evaluate the efficacy and safety of regional citrate anticoagulation (RCA) plus low-dose dalteparin in patients receiving continuous veno-venous hemofiltration (CVVH). Methods: Patients requiring pre-dilution CVVH...

...Manuel Molina Nuñez; Rosa de Alarcón; Susana Roca; Gracia Álvarez; María Soledad Ros; Cristina Jimeno; Laura Bucalo; Isabel Villegas; María Ángeles García Background and Aims: A bicarbonate dialysate acidified with citrate (CD) has been reported to have local anticoagulant effect and improves...

...Georg F. Lehner; Marion SchFpf; Ulrich Harler; Christoph Pechlaner; Michael Joannidis Purpose: Early clinical signs of heparin induced thrombocytopenia (HIT) are nonspecific and include a sudden drop in the number of platelets as well as formation of arterial and venous thromboses. Regional citrate...

... a novel approach. Methods: The literature was reviewed for limitations of hybrid protocols, use of regional citrate anticoagulation (RCA) on hybrid systems and sensors for IHD and hybrid therapy. The novel hybrid program in the authors’ institution is presented as a plausible future direction...

...Martin Balik; Mykhaylo Zakharchenko; Michal Otahal; Jan Hruby; Ferdinand Polak; Katerina Rusinova; Zdenek Stach; Jaroslava Vavrova; Antonin Jabor Background: There are limited data on systemic delivery of metabolic substrates during citrate anticoagulation. The direct citrate measurements...