... with systemic antibiotic, antibiotic lock (ABL) is an important therapeutic option to salvage the catheter. With extra antimicrobial and biofilm removing properties, urokinase plasminogen activator (uPA)-based ABL could have a potential role in the treatment of CRBSI. Objective: In this study, we aimed...

...Karine Marion; Mark Pasmore; Jean Freney; Ehsan Delawari; François Renaud; John William Costerton; Jules Traeger Most currently used disinfectants for dialysis machines have a good bactericidal efficacy on biofilms but leave dead cells on the surface. This contributes to the regrowth of biofilm...

...C.J. Holmes; A. Degremont; W. Kubey; P. Straka; N.K. Man The development of bacterial biofilms in the hydraulic circuit of hemodialysis machines is routinely prevented by frequent use of a variety of chemical and heat disinfection strategies. This study compared the effectiveness of several...

...Gerhard Lonnemann Dialysis fluid produced by state-of-the-art water preparation and distribution is contaminated with gram-negative bacteria and cytokine-inducing substances (CIS) derived from these microorganisms. The presence of a biofilm increases the risk of continuous contamination of dialysis...

...G. Cappelli; M. Ballestri; S. Perrone; A. Ciuffreda; P. Inguaggiato; A. Albertazzi Bacteria attach to surfaces and aggregate in a biopolymer matrix to form biofilm. Studies on biofilm have shown its presence in many prosthetic devices used in nephrology as well as in fluid pathways of hemodialysis...