Abstract
In recent years, extracorporeal hemadsorption (HA) techniques capable of adsorbing pro- and anti-inflammatory cytokines are increasingly used in various clinical situations. The therapeutic benefit of cytokine elimination likely depends on timing. Although treatment seems to be most effective when started within the first 24 h, therapy is often delayed as it must be combined with another extracorporeal circuit. Thus, using a pumpless extracorporeal HA technique might be a valuable option in order to expedite the commencement of cytokine elimination in critically ill patients.
References
1.
Ankawi
G
, Xie
Y
, Yang
B
, Xie
Y
, Xie
P
, Ronco
C
. What have we learned about the use of cytosorb adsorption columns?
Blood Purif
. 2019
;48
(3
):196
–202
. .2.
Chen
G
, Zhou
Y
, Ma
J
, Xia
P
, Qin
Y
, Li
X
. Is there a role for blood purification therapies targeting cytokine storm syndrome in critically severe COVID-19 patients?
Ren Fail
. 2020
;42
(1
):483
–8
. .3.
Kogelmann
K
, Jarczak
D
, Scheller
M
, Drüner
M
. Hemoadsorption by cytoSorb in septic patients: a case series
. Crit Care
. 2017
;21
(1
):74
. .4.
Brouwer
WP
, Duran
S
, Kuijper
M
, Ince
C
. Hemoadsorption with cytoSorb shows a decreased observed versus expected 28-day all-cause mortality in ICU patients with septic shock: a propensity-score-weighted retrospective study
. Crit Care
. 2019
;23
(1
):317
. .5.
Schadler
D
, Pausch
C
, Heise
D
, Meier-Hellmann
A
, Brederlau
J
, Weiler
N
, The effect of a novel extracorporeal cytokine hemoadsorption device on IL-6 elimination in septic patients: a randomized controlled trial
. PLoS One
. 2017
;12
(10
):e0187015
.© 2021 S. Karger AG, Basel
2021
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.
