Abstract
Hemophagocytic lymphohistiocytosis (HLH), a life-threatening disease with uncontrolled immune activation and inflammatory reaction, often leads to a deadly cytokine storm. In severe Ebstein-Barr virus-triggered HLH receiving standard immunosuppression, continuous renal replacement therapy (CRRT) with oXiris® blood purification membrane resulted in a timely reduction of inflammatory markers and discontinuation of vasopressors. To our knowledge, this is the first report of successful use of the oXiris® membrane in HLH.
References
1.
Ramos-Casals
M
, Brito-Zerón
P
, López-Guillermo
A
, Khamashta
MA
, Bosch
X
. Adult haemophagocytic syndrome
. Lancet
. 2014
;383
(9927
):1503
–16
. .2.
Larroche
C
. Hemophagocytic lymphohistiocytosis in adults: diagnosis and treatment
. Joint Bone Spine
. 2012
;79
(4
):356
–61
. .3.
Henter
J-I
, Aricò
M
, Egeler
RM
, Elinder
G
, Favara
BE
, Filipovich
AH
, et al HLH-94: a treatment protocol for hemophagocytic lymphohistiocytosis
. Medical and Pediatric Oncology
. 1997
;28
(5
):342
–7
.4.
Machowicz
R
, Janka
G
, Wiktor-Jedrzejczak
W
. Similar but not the same: differential diagnosis of HLH and sepsis
. Crit Rev Oncol Hematol
. 2017
;114
:1
–12
. .5.
Tandukar
S
, Palevsky
PM
. Continuous renal replacement therapy: who, when, why, and how
. Chest
. 2019
;155
(3
):626
–38
. .6.
Monard
C
, Rimmelé
T
, Ronco
C
. Extracorporeal blood purification therapies for sepsis
. Blood Purif
. 2019
;47
(Suppl 3
):2
–15
. .7.
Broman
ME
, Hansson
F
, Vincent
JL
, Bodelsson
M
. Endotoxin and cytokine reducing properties of the oXiris membrane in patients with septic shock: a randomized crossover double-blind study
. PLoS One
. 2019
;14
(8
):e0220444
. .8.
Schwindenhammer
V
, Girardot
T
, Chaulier
K
, Grégoire
A
, Monard
C
, Huriaux
L
, et al oXiris® use in septic shock: experience of two French centres
. Blood Purif
. 2019
;47
(Suppl 3
):29
–35
.9.
Frimmel
S
, Hinz
M
, Schipper
J
, Bogdanow
S
, Mitzner
S
, Koball
S
. Cytokine adsorption is a promising tool in the therapy of hemophagocytic lymphohistiocytosis
. Int J Artif Organs
. 2019
;42
(11
):658
–64
. .10.
Broman
ME
, Bodelsson
M
. Analysis of endotoxin adsorption in two Swedish patients with septic shock
. Blood Purif
. 2019
;47
(Suppl 3
):1
–3
. .11.
Turani
F
, Barchetta
R
, Falco
M
, Busatti
S
, Weltert
L
. Continuous renal replacement therapy with the adsorbing filter oXiris in septic patients: a case series
. Blood Purif
. 2019
;47
(Suppl 3
):1
–5
.12.
Zhang
C
, Sun
B
, Lin
T
, Wang
W
, Jin
Y
, Liu
S
, et al [Usage of oXiris hemofilter for septic shock patients: a single-center experience]
. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
. 2019
;31
(12
):1531
–4
. .13.
Villa
G
, De Rosa
S
, Samoni
S
, Neri
M
, Cosimo
C
, Romagnoli
S
, et al oXiris Net Registry: a Prospective, National Registry on the oXiris Membrane
. Blood Purif
. 2019
;47
(Suppl 3
):1
–8
. .14.
Fardet
L
, Galicier
L
, Lambotte
O
, Marzac
C
, Aumont
C
, Chahwan
D
, et al Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome
. Arthritis Rheumatol
. 2014
;66
(9
):2613
–20
. .© 2020 S. Karger AG, Basel
2020
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