Chronic kidney disease is complex in both adults and children, but the disease is far from the same between these populations. Here we review the marked differences in etiology, comorbidities, impact of disease on growth and quality of life, issues unique to adolescents and transitions to adult care, and special considerations of congenital kidney and urinary tract anomalies for transplantation.

1.
Baum M: Overview of chronic kidney disease in children. Curr Opin Pediatr 2010;22:158-160.
2.
Wong CJ, et al: CKiD (CKD in children) prospective cohort study: a review of current findings. Am J Kidney Dis 2012;60:1002-1011.
3.
Harambat J, et al: Epidemiology of chronic kidney disease in children. Pediatr Nephrol 2012;27:363-373.
4.
NAPRTCS, North American Pediatric Renal Trials and Collaborative Studies: 2011 Annual Dialysis Report, 2011.
5.
Saran R, Li Y, Robinson B, et al: US Renal Data System 2014 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis 2015;66(1 suppl 1):Svii, S1-S305.
6.
Xiao N, et al: Kidney function in severely obese adolescents undergoing bariatric surgery. Obesity (Silver Spring) 2014;22:2319-2325.
7.
Ding W, Cheung WW, Mak RH: Impact of obesity on kidney function and blood pressure in children. World J Nephrol 2015;4:223-229.
8.
Vikse BE, et al: Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol 2008;19:151-157.
9.
Carmody JB, Charlton JR: Short-term gestation, long-term risk: prematurity and chronic kidney disease. Pediatrics 2013;131:1168-1179.
10.
Schaefer F, et al: Growth charts for prepubertal children with chronic renal failure due to congenital renal disorders. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. Pediatr Nephrol 1996;10:288-293.
11.
Warady BA, Schaefer F, Alexander SR (eds): Pediatric Dialysis, ed 2. New York, Springer, 2012, pp xix, 825.
12.
Seikaly MG, et al: The effect of rhGH on height velocity and BMI in children with CKD: a report of the NAPRTCS registry. Pediatr Nephrol 2009;24:1711-1717.
13.
Clinical Pediatric Nephrology, ed 2. Informa Healthcare, 2007.
14.
Scialla JJ, et al: Mineral metabolites and CKD progression in African Americans. J Am Soc Nephrol 2013;24:125-135.
15.
Wilson AC, et al: High prevalence of the metabolic syndrome and associated left ventricular hypertrophy in pediatric renal transplant recipients. Pediatr Transplant 2010;14:52-60.
16.
Wilson AC, et al: Prevalence and correlates of multiple cardiovascular risk factors in children with chronic kidney disease. Clin J Am Soc Nephrol 2011;6:2759-2765.
17.
Schaefer F, Mehls O, et al: Strict blood-pressure control and progression of renal failure in children. N Engl J Med 2009;361:1639-1650.
18.
Fadrowski JJ, et al: Hemoglobin decline in children with chronic kidney disease: baseline results from the chronic kidney disease in children prospective cohort study. Clin J Am Soc Nephrol 2008;3:457-462.
19.
Copelovitch L, Warady BA, Furth SL: Insights from the chronic kidney disease in children (CKiD) study. Clin J Am Soc Nephrol 2011;6:2047-2053.
20.
Müller-Wiefel DE, et al: Hemolysis and blood loss in children with chronic renal failure. Clin Nephrol 1977;8:481-486.
21.
von Lilien T, et al: Five years' experience with continuous ambulatory or continuous cycling peritoneal dialysis in children. J Pediatr 1987;111:513-518.
22.
Lerner G, et al: Pharmacokinetics of darbepoetin alfa in pediatric patients with chronic kidney disease. Pediatr Nephrol 2002;17:933-937.
23.
Gerson AC, et al: Health-related quality of life of children with mild to moderate chronic kidney disease. Pediatrics 2010;125:e349-e357.
24.
Moreira JM, et al: Anxiety, depression, resilience and quality of life in children and adolescents with pre-dialysis chronic kidney disease. Pediatr Nephrol 2015, Epub ahead of print.
25.
Al-Uzri A, et al: The impact of short stature on health-related quality of life in children with chronic kidney disease. J Pediatr 2013;163:736-741.e1.
26.
Gerson A, et al: Anemia and health-related quality of life in adolescents with chronic kidney disease. Am J Kidney Dis 2004;44:1017-1023.
27.
Roumelioti ME, et al: Sleep and fatigue symptoms in children and adolescents with CKD: a cross-sectional analysis from the chronic kidney disease in children (CKiD) study. Am J Kidney Dis 2010;55:269-280.
28.
Hooper SR, et al: Neurocognitive functioning of children and adolescents with mild-to-moderate chronic kidney disease. Clin J Am Soc Nephrol 2011;6:1824-1830.
29.
Cerqueira DC, Soares CM, Silva VR, Magalhães JO, Barcelos IP, Duarte MG, Pinheiro SV, Colosimo EA, Simões e Silva AC, Oliveira EA: A predictive model of progression of CKD to ESRD in a predialysis pediatric interdisciplinary program. Clin J Am Soc Nephrol 2014;9:728-735.
30.
Wong CS, et al: Association of proteinuria with race, cause of chronic kidney disease, and glomerular filtration rate in the chronic kidney disease in children study. Clin J Am Soc Nephrol 2009;4:812-819.
31.
Warady BA, et al: Predictors of rapid progression of glomerular and nonglomerular kidney disease in children and adolescents: the chronic kidney disease in children (CKiD) cohort. Am J Kidney Dis 2015;65:878-888.
32.
Ardissino G, et al: Puberty is associated with increased deterioration of renal function in patients with CKD: data from the ItalKid project. Arch Dis Child 2012;97:885-888.
33.
Butani L, Perez RV: Effect of pretransplant dialysis modality and duration on long-term outcomes of children receiving renal transplants. Transplantation 2011;91:447-451.
34.
Patzer RE, et al: Racial and ethnic differences in pediatric access to preemptive kidney transplantation in the United States. Am J Transplant 2013;13:1769-1781.
35.
Patzer RE, et al: Racial and ethnic disparities in pediatric renal allograft survival in the United States. Kidney Int 2015;87:584-592.
36.
Dharnidharka VR, Fiorina P, Harmon WE: Kidney transplantation in children. N Engl J Med 2014;371:549-558.
37.
Halloran PF: Immunosuppressive drugs for kidney transplantation. N Engl J Med 2004;351:2715-2729.
38.
Muller D, et al: Intensified hemodialysis regimens: neglected treatment options for children and adolescents. Pediatr Nephrol 2008;23:1729-1736.
39.
Weinhandl ED, Gilbertson DT, Collins AJ: Mortality, hospitalization, and technique failure in daily home hemodialysis and matched peritoneal dialysis patients: a matched cohort study. Am J Kidney Dis 2015;pii:S0272-6386(15)01018-5.
40.
Schwartz GJ, et al: Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C. Kidney Int 2012;82:445-453.
41.
Jesus LE, Pippi Salle JL: Pre-transplant management of valve bladder: a critical literature review. J Pediatr Urol 2015;11:5-11.
42.
Pereira PL, et al: Renal transplantation in augmented bladders. Curr Urol Rep 2014;15:431.
43.
Fredericks EM, Dore-Stites D: Adherence to immunosuppressants: how can it be improved in adolescent organ transplant recipients? Curr Opin Organ Transplant 2010;15:614-620.
44.
Foster BJ, et al: The TAKE-IT study: aims, design, and methods. BMC Nephrol 2014;15:139.
45.
Bell LE, Sawyer SM: Transition of care to adult services for pediatric solid-organ transplant recipients. Pediatr Clin North Am 2010;57:593-610.
46.
Van Arendonk KJ, et al: Age at graft loss after pediatric kidney transplantation: exploring the high-risk age window. Clin J Am Soc Nephrol 2013;8:1019-1026.
47.
Akchurin OM, et al: Medication adherence in the transition of adolescent kidney transplant recipients to the adult care. Pediatr Transplant 2014;18:538-548.
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