Prurigo nodularis is a skin disease with unknown origin which is frequent in patients on maintenance renal replacement therapy. Here, we report a patient who was dialyzed for more than 10 years with different dialyzers using different dialyzer membranes. Each time when the patient was switched to a polymethylmethacrylate membrane (Filtryzer BK-1.6P), itching and skin lesions disappeared completely. This effect could be verified three times.

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Pisoni R, Wikström B, Elder SJ, Akizawa T, Asano Y, Keen ML, Saran R, Mendelsohn DC, Young EW, Port FK: Pruritus in haemodialysis patients: international results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 2006;21:3495-3505.
Aucella F, Vigilante M, Gesuete A: Review: the effect of polymethylmethacrylate dialysis membranes on uremic pruritus. NDT Plus 2010;3(suppl 1):i8-i11.
Aucella F, Vigilante M, Gesuete A, Maruccio G, Specchio A, Gesualdo L: Uraemic itching: do polymethylmethacrylate dialysis membranes play a role? Nephrol Dial Transplant 2007;22(suppl 5):v8-v12.
Kato A, Takita T, Furuhashi M, et al: Polymethylmethacrylate efficacy in reduction of renal itching in hemodialysis patients: crossover study and role of tumor necrosis factor-alpha. Artif Organs 2001;25:441-447.
Mann H, Melzer H, Al-Bashir A, Xu XQ, Stiller S: Testing protein permeability of dialysis membranes using SDS-PAGE. Int J Artif Organs 2002;25:441-446.
Narita I, Aichi B, Omori K, et al: The effect of polymethylmethacrylate dialysis membranes on uremic pruritus. Kidney Int 2006;69:1626-1632.
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