Adequate feeding of critically ill patients under continuous renal replacement therapy (CRRT) remains a challenging issue. We performed a systematic search of the literature published between 1992 and 2012 using the quorum guidelines regarding nutrition in intensive care unit patients treated with CRRT. Daily recommended energy requirements during CRRT are between 25 and 35 kcal/kg with carbohydrates and lipids accounting for 60-70% and 30-40% of calorie intake, respectively. Daily protein needs range from 1.5 to 1.8 g/kg. Indirect calorimetry corrected for CRRT-induced CO2 diversion should be used to more correctly match calorie intake to the real needs. This type of tool is not yet available but hopefully soon. Electrolyte deficit as well as overload have been described during CRRT but, in general, can be easily controlled. Although not strongly evidenced, consensus exists to supplement important micronutrients such as amino acids (glutamine), water-soluble vitamins and trace elements.

1.
Wiesen P, Van Overmeire L, Delanaye P, Dubois B, Preiser JC: Nutrition disorders during acute renal failure and renal replacement therapy. J Parenter Enteral Nutr 2011;35:217-222.
2.
Leverve X, Cano NJM: Nutritional Management in Acute Illness and Acute Kidney Insuffiency. Contrib Nephrol. Basel, Karger, 2010, vol 156, pp 112-118.
3.
Bellomo R, Tan HK, Bhonagri S et al: High protein intake during continuous hemodiafiltration: impact on aminosides and nitrogen balance. Int J Artif Organs 2002;25:261-268.
4.
Palewsky PM, Zhang JH, O'Connor TZ, Chertow GM, Crowley ST, Choudury D, et al, for the VA/NIH Acute Renal Trial Network: Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med 2008;359:7-20
5.
RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, McArthur C, McGuinness S, Myburgh J, Norton R, Scheinkestel C, Su S: Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med 2009;361:1627-1638.
6.
Prowle JR, Bellomo R: Continuous renal replacement therapy: recent advances and future research. Nat Rev Nephrol 2010;6:521-529.
7.
Santoro A, Mancini E, London G, et al: Patients with complex arrhythmias during and after haemodialysis suffer from different regimens of potassium removal. Nephrol Dial Transplant 2008;23:1415-1421.
8.
Alsumrain MH, Jawad SA, Imran NB, Riar S, DeBari VA, Adelman M: Association of hypophosphatemia with failure-to-wean from mechanical ventilation. Ann Clin Lab Sci 2010;40:144-148.
9.
Troyanov S, Geadah D, Ghannoum M, Cardinal J, Leblanc M: Phosphate addition to hemodiafiltration solutions during continuous renal replacement therapy. Intensive Care Med 2004;30:1662-16
10.
Machado JD, Suen VM, Chueire FB, Marchini JF, Marchini JS: Refeeding syndrome, an undiagnosed and forgotten potentially fatal condition. BMJ Case Rep 2009; epub 2009 Mar 5.
11.
Honore PM, Jacobs R, Joannes-Boyau O, et al: Septic AKI in ICU patients. Diagnosis, pathophysiology, and treatment type, dosing, and timing: a comprehensive review of recent and future developments. Ann Intensive Care 2011;9:1:32.
12.
Ratanarat R, Brendolan A, Volker G, et al: Phosphate kinetics during different dialysis modalities. Blood Purif 2005;23:83-90.
13.
Lochy S, Jacobs R, Honore PM et al: Phosphate induced crystal acute kidney injury: an underrecognized cause of chronic kidney disease. Case report and review of the literature. Int J Nephrol Renovasc Dis 2013;6:61-66.
14.
Uchino S, Bellomo R, Morimatsu H, et al: Continuous renal replacement therapy. A worldwide practice survey. The Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) investigators. Intensive Care Med 2007;33:1563-1570.
15.
Rimmelé T, Wey PF, Bernard N, Monchi M et al: Hemofiltration with the cascade system in an experimental porcine model of septic shock. Ther Apher Dial 2009;13:63-70.
16.
Frankenfield DC, Reynolds HN, Badellino MM, Wiles CE: Glucose dynamics during continuous hemodiafiltration and total parenteral nutrition. Intensive Care Med 1995;21:1016-1022.
17.
Monaghan R, Watters JM, Clancey SM, Moulton SB, Rabin EZ: Uptake of glucose during continuous arteriovenous hemofiltration. Crit Care Med 1993;21:1159-1163.
18.
Bonnardeaux A, Pichette V, Ouimet D, Geadah D, Habel F, Cardinal J: Solute clearances with high dialysate flow rates and glucose absorption from the dialysate in continuous arteriovenous hemodialysis. Am J Kidney Dis 1992;19:31-38.
19.
Vaussenat F, Canaud B, Bosc JY, Leblanc M, Leray-Moragues H, Garred LJ: Intradialytic glucose infusion increases polysulphone membrane permeability and post-dilutional haemodiafiltration performances. Nephrol Dial Transplant 2000;15:511-516.
20.
Bollmann MD, Revelly JP, Tappy L, et al: Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure. Intensive Care Med 2004;30:1103-1110.
21.
Javid PJ, Halwick DR, Betit P, et al: The first use of live continuous glucose monitoring in patients on extracorporeal life support. Diabetes Technol Ther 2005;7:431-439.
22.
Singer P, Berger MM, Van den Berghe G, Biolo G, Calder P, Forbes A, Griffiths R, Kreyman G, Leverve X, Pichard C: ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr 2009;28:387-400.
23.
Stefanutti C, Di giacoma S, Labbadia G: Timing clinical events in the treatment of pancreatitis and hypertriglyceridemia with therapeutic plasmapheresis. Transf Aphrer Sci 2011;45:3-7.
24.
Kazory A, Clapp WL, Ejaz AA, Ross A: Shortened hemofilter survival time due to lipid infusion in continuous renal replacement therapy. Nephron Clin Pract 2008;108:5-9.
25.
Story DA, Ronco C, Bellomo R: Trace elements and vitamin concentration and losses in critically ill patients treated with continuous venovenous hemofiltration. Crit Care Med 1999;27:220-223.
26.
Berger MM, Shenkin A, Revelly JP, et al: Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients. Am J Clin Nutr 2004;80:410-416.
27.
Klein CJ, Nielsen FH, Moser-Veillon PB: Trace elements loss in urine and effluent following traumatic injury. J Parenter Enteral Nutr 2008;32:129-139.
28.
Cano NJ, Aparicio M, Brunori G, Carrero JJ, Cianciaruso B, Fiaccadori E, Lindholm B, Teplan V, Fouque D, Guarnieri G: ESPEN Guidelines on Parenteral Nutrition: adult renal failure. Clin Nutr 2009;28:401-414.
29.
Chiolero R, Berger MM: Nutritional Support during Renal Replacement Therapy. Contrib Nephrol. Basel, Karger, 2007, vol 156, pp 267-274.
30.
Honore PM: Macronutrients and micronutrients requirements during CRRT. An update. Proc Ann Belg Nutr Symp 1999;10:45-61.
31.
Lopez Martinez J, Sanchez-Izquierdo Riera JA, Jimenez Jimenez FJ: Guidelines for specialized nutritional and metabolic support in the critically-ill patient: update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units and the Spanish Society of parenteral and Enteral Nutrition (SEMICYUC-SENPE): Acute Renal Failure. Med Intensiva 2011;35(suppl):22-27.
32.
Yagi N, Leblanc M, Sokal K, Wright EJ, Paganini EP: Cooling effect of continuous renal replacement therapy in critically ill patients. Am J Kidney Dis 1998;32:1023-1030
33.
Robert R, Mehaud JE, Timricht N, Goudet V, Mimoz O, Debaene B: Benefits of early cooling phase in continuous renal replacement therapy for ICU patients. Ann Intensive Care 2012;2:40.
34.
Karacon H, Valentin A, Carl P: Mild therapeutic hypothermia after cardiac arrest through continuous dialysis. Ugeskr Laeger 2009;171:1395-1400.
35.
Manns M, Maurer E, Steinbecht B, Elaly HG. Thermal energy balance during in vitro continuous hemofiltration. ASAIO J 1998;44:601-605.
36.
36)Honore PM, Jacobs R, Joannes-Boyau O et al: Newly designed CRRT membranes for sepsis and SIRS: a pragmatic approach for bedside intensivists summarizing the more recent advances. A systematic structured review. ASAIO J 2013;59:99-106.
37.
De Waele E, Spapen H, Honoré PM, Mattens S, Rose T, Huyghens L: Bedside calculation of energy expenditure does not guarantee adequate caloric prescription in long-term mechanically ventilated critically ill patients: a quality control study. Scientific World J 2012;2012:909564.
38.
Maynar J, Honoré PM, Sanchez-Izquierdo JA, Herrera M, Spapen HD: Handling CRRT-related adverse effects in ICU patients: the dialytrauma concept. Blood Purif 2012;34:177-187.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.