A theory was developed allowing the prediction of the spillage volume after injection of locking solution into a catheter. This theory was corroborated by in-vitro measurements using colorized fluid injected automatically by a micropump into a stirred container with clear fluid. The amount of spilled solution was measured with a fiberoptic spectrometer equipped with a dip probe. Straight cylindrical tubing was used as catheter. Results: The theory predicts the beginning of spillage when 50% of the catheter filling volume is injected. When the nominal filling volume is injected, 25% of the solution is spilled and the mean concentration at the catheter tip is 50% of the locking solution concentration. Experiments: Spillage was slightly less than predicted (20–25% at nominal filling volume). During the experiments it was recognized that a small air bubble trapped in the Luer connection during connection reduces the spillage volume to 10–15%.

Keywords:
Blood access, Catheter, Locking solutions, Spillage, Photometry
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© 2008 S. Karger AG, Basel
2008
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